Mayo Clinic researchers use pharmacogenetic test prior to chemotherapy to reduce toxic side effects
... particularly toxic for some patients. Despite the antitumor benefit of each drug, researchers have had difficulty putting the drugs together because the toxicity can be lethal. The genetic test detects a change in the DNA of a gene that encodes for a protein involved in the metabolism of irinotecan. The test ...Researchers study natural products that may prevent certain cancers
...n plant polyphenolic compounds that exhibit potent antitumor activities. Caffeic Acid Phenethyl Ester (CAPE) is the major active ingredient in propolis, a resinous substance collected by bees from the bark and leaves of trees and plants. Propolis extracts have been used since ancient times as antibacterial and...Cancer researcher Susan Horwitz wins Alpert prize for Taxol work
...inal contributions to the understanding of how the antitumor agent Taxol inhibits the growth of cancer cells. Her research helped pave the way for studies leading to approval of the plant compound for the treatment of ovarian, breast and lung cancers. The foundation will award Dr. Horwitz a $150,000 prize. "On...Flavonoids may inhibit prostate cancer
...l, anti-allergic, antiplatelet, anti-inflammatory, antitumor and antioxidant activities," Gupta said. "Apigenin has been shown to lower inflammation and oxidative stress, and exerts growth inhibitory effects on cancer cells." In the study, Gupta and his team orally fed apigenin to mice two weeks before implant...Albert Szent-Gyrgyi Prize for Progress in Cancer Research to Harvard's Harold F. Dvorak, M.D.
... inhibit VEGF have also shown outstanding clinical antitumor activity with dramatic therapeutic effects for patients worldwide." "Dr. Dvorak's seminal discoveries in basic science have led to significant clinical benefits for cancer patients, perfectly fitting the unique criteria of the Albert Szent-Gyrgyi Pri...Lack of response to herceptin may be reversed with addition of a PI3K inhibitor
...ey found that one, RAD001 (everolimus), had better antitumor activity when combined with Herceptin than did Herceptin or RAD001 alone. Another PI3K inhibitor, TCN-P (triciribine), showed significant benefit when used in combination with Herceptin, Yu says. Even with a low dose of TCN-P, the combination therap...BIDMC's Harold Dvorak, MD, honored by National Foundation for Cancer Research
... inhibit VEGF have also shown outstanding clinical antitumor activity with dramatic therapeutic effects for patients worldwide." Dvorak's original findings, published in the journal Science, demonstrated that tumors secreted VPF/VEGF. This discovery provided the molecular basis for the field of angiogenesis....Preliminary study shows promise for treatment of renal cell cancer
...nducted a multicenter phase 2 trial to confirm the antitumor efficacy of sunitinib in 106 patients with metasta... a 4 weeks on/2 weeks off schedule has substantial antitumor effects against metastatic clear-cell RCC. Of the 105 evaluable patients, 36 patients achieved parti...JCI table of contents, June 8, 2006
...om the Mayo Clinic College of Medicine show that 2 antitumor agents, cisplatin and paclitaxel, increase the expression of the protein HtrA1 in ovarian carcinoma cells, which induces cell death. Conversely, reduced HtrA1 expression reduced the effectiveness of cisplatin and paclitaxel. The authors went on to t...HtrA1 and resistance to chemotherapy in ovarian and gastric cancers
...om the Mayo Clinic College of Medicine show that 2 antitumor agents, cisplatin and paclitaxel, increase the expression of the protein HtrA1 in ovarian carcinoma cells, which induces cell death. Conversely, reduced HtrA1 expression reduced the effectiveness of cisplatin and paclitaxel. The authors went on to t......ell. Here, the contents of the capsule, such as an antitumor drug or contrast agent, can be released to selectively attack the tumor or to make an unambiguous diagnosis....Therapeutic unshackles p53 and causes tumor regression
...nd that the small-molecule inhibitor Nutlin-3a has antitumor effects in a mouse xenograft model of PEL. In the study, which appears online on March 15 in advance of publication in the April print issue of the Journal of Clinical Investigation, Pivi Ojala and colleagues show that Nutlin-3a induces human PEL c...NY-Presbyterian Hospital/Columbia University Medical Center doctors present at 2007 AUA Meeting
...s a novel oral platinum compound with demonstrated antitumor activity in a variety of tumors, including HRPC. The SPARC trial is a large, double-blind, placebo-controlled, phase III study, evaluating S in combination with prednisone (P) for the treatment of HRPC patients who have failed one prior chemotherapy ...Phase II study shows combination improves survival of metastatic melanoma patients
... with a drug like bevacizumab could facilitate the antitumor effects of chemotherapy in patients with metastatic melanoma. Bevacizumab is a monoclonal antibody that binds VEGF and blocks its interaction with cellular receptors. This action prevents new blood vessels from forming and allows the chemotherapy t......molecule (antigen) for antibodies in immunological antitumor therapy. The difficulty with this approach is that such sugar-containing compounds are completely ineffective at stimulating the immune system to form antibodies. Immunization is only successful if the vaccine is anchored to an immunizing carrier pr...