Combating fatigue associated with liver disease
...atigue associated with PBC, an inflammation of the bile ducts in the liver that leads to cirrhosis. Fatigue is often associated with depression, which may be caused by abnormalities in serotonin transmission; ondansetron helps regulate serotonin levels, which suggests its potential as a treatment for fati...Use of laparoscopic procedure for gallbladder removal varies widely
...or many surgeons--mainly because of concerns about bile duct injuries and an excessively high conversion rate (a procedure that begins using the laparoscopic technique, but then requires "converting" to an open laparotomy for gall bladder removal). "The application of LC in the emergency condition is tech...Radiation treatment prolonged liver cancer patients' lives, U-M study finds
...e researchers looked specifically at patients with bile duct cancer, liver cancer or colon cancer that had...iver cancer patients lived an average 15.2 months, bile duct cancer patients lived 13.3 months and colon cancer patients lived 17.2 months. "The patients w...Liver transplants may not be indicated for cystic fibrosis patients with bleeding complication
...e liver disease in CF patients may involve damaged bile ducts, "variceal bleeding in patients with cystic fibrosis does not necessarily indicate a significant deficit of hepatocellular function," the authors state. This is important because the poor prognosis seen after variceal bleeding in patients with ...Understanding fatigue in chronic liver disease
... and fatigue. In cholestatic liver diseases (where bile production is impaired) such as primary biliary ci...lved creating cholestasis in mice by tying off the bile duct. Cerebral endothelial cells (cells lining the blood vessels of the brain) were then isolated an...Despite medical advances, children receiving liver transplants wait longer than a decade ago
...while biliary atresia (a congenital absence of the bile ducts) remained the most common indication for a transplant, it accounted for almost half of the transplants in the earlier period compared to about one third in the later period, while there was an increase in tumors as an indication for transplant....Enzyme inhibitor may help lower cholesterol and unclog arteries
... delivers it to the liver, where it is excreted as bile salts and cholesterol. In a study appearing in the May issue of the Journal of Clinical Investigation, Fumihiko Matsuura and colleagues from Columbia University, New York, reveal new features of this pathway that suggest an enzyme inhibitor currently...JCI table of contents: May 1, 2006
...ransports it to the liver, where it is excreted as bile salts and cholesterol. In a study appearing in the May issue of the Journal of Clinical Investigation, Fumihiko Matsuura and colleagues from Columbia University, New York, reveal new features of this pathway that suggest an enzyme inhibitor currently...Skin rash in patients treated for liver cancer determines survival
...d 57 patients with advanced liver, gallbladder and bile duct cancers who were not candidates for surgery and who received a new agent called lapatinib that prevents two epidermal growth factors receptor (EGFR) pathways from becoming activated in cancer cells. The EGFR pathway has been implicated in the gr......s that 18,510 new cases of primary livercancer and bile duct cancer will be diagnosed in the United States during2006, and around 16,200 people will die of liver cancer. Studies in mice by Zhi Yuan and his team at Nankai University, China, revealed that the liquorice compounds, glycerrhetinic acid and gly...JCI table of contents, June 8, 2006
... in the livers of these mice. Tumors formed in the bile ducts of these animals by 47 months of age. The authors show that SMAD4 and PTEN regulate each others' activity in order to balance their expression and repress CC formation. The authors also examined human CC specimens and found that PTEN was inacti...Pancreatic cancer surgery can help those over 80, Jefferson surgeons find
... (part of the small intestine), part of the common bile duct, the gallbladder and sometimes a portion of the stomach. Of this group, 207 patients were 80 years old or older. Those who were 80 to 89 years of age had a mortality rate of 4.1 percent (8 of 197), and a complication rate of 52.8 percent. Those...Cincinnati surgeon's pediatric laparoscopic liver surgery a world first
... from the intestines in the blood supply, produces bile to help digest fats, and stores energy-producing g...about 18,000 new cases of primary liver cancer and bile duct cancer will be diagnosed in the United States during 2006. Because of a higher incidence rate o...Bone mass continues to increase in liver transplant patients, despite early loss
... in patients with cholestatic liver disease (where bile production stops). However, the underlying mechani...or primary sclerosing cholangitis (PSC), where the bile ducts become inflamed and obstructed, causing bile to build up in the liver and damage it. Patients ...Cancer drug side effect caused by cell 'pump' problem
...pushes drugs into a tube-like structure called the bile canaliculum, which eventually leads to the intestine, from which it is excreted, according to the researchers. ABCG2 also pumps drugs out of the cells lining the intestine, preventing drugs taken by mouth from flooding into the body. Once past the in...'Dua Anti-reflux Valve' found to improve quality of life for bile duct/pancreatic cancer patients
This bile duct stent with the "Dua Anti-Reflux Valve," named... been approved for use in Europe and Canada. The bile duct carries bile from the liver to the intestines. When this duct is obstructed from cancers of the...Gene chip discovery may lead to individualized treatment for 5 hereditary liver diseases
...owing of the eyes and skin caused by impairment in bile flow from the liver to the intestine. Impaired bile flow, or cholestasis, commonly known as jaundice, can lead to severe liver disease. In children, jau...Pancreatic cancer surgery five-year survivors 65 and up live nearly as long as anyone
...ich entails the removal of the gallbladder, common bile duct, part of the duodenum, and the head of the pancreas, between 1970 and 1999 at Johns Hopkins University. They identified those who lived for five years, and compared those who lived for at least an additional five years to the "actuarial" or est...New reflux guidelines released
...curate diagnoses. "Wireless capsule pH monitoring, bile acid reflux monitoring devices and esophageal impedance can all improve the detection of reflux," says Dr. Hirano. These technologies have helped gastroenterologists to discover new forms of reflux, and to better characterize traditional acid reflux.......er patients also has been shown to help those with bile duct obstruction, according to Kulwinder S. Dua, M...y stent in patients with cancer of the pancreas or bile duct, appears in the May issue of Gastrointestinal Endoscopy journal. This bile duct stent with the...