Top anti-arthritis drugs cause skin disease
...is drugs, Tumour Necrosis Factor alpha (TNF-alpha) blocking agents, trigger skin conditions in 25% of patients undergoing treatment. TNF-alpha blocking agents are used to halt the process of joint destruction in patients with severe arthritis condition...'Promiscuous' area of brain could explain role of antidepressants
...of the neurotransmitter serotonin in the brain. By blocking the uptake of serotonin after its initial release, conventional antidepressants provide the brain more serotonin for a longer period of time. An alternative approach suggested by this study is to develop antidepressant treatments that help serotonin ...Scientist works to reduce side effects of radiation therapy
...rket are designed to treat obesity and diabetes by blocking the receptors. Robbins believes that the same drugs may be able to prevent or reduce the severity of cognitive impairment after whole-brain radiation. "The drugs are available and we know the doses that patients can safely take," said Robbins. "If ou...Drugs targeted at muscle cells
...glucose absorption into the cells. By specifically blocking certain processes in the cells, the scientists were also able to show that the effects of the drugs resembled those caused by physical activity. They were also able to show that this was not the result of any effect on insulin signals. "The discoveri...More evidence suggests statins help cut risk for advanced prostate cancer
...te this," says Platz. Statins lower cholesterol by blocking an enzyme that controls its assembly. There are clues to suggest key cellular pathways involved in cancer-risk reduction may include statins' effects on testosterone production, cell signaling, and inflammation. Or the drugs may play a role in chan...CML found to wield 'death factor' that kills normal blood marrow cells
...archers. Because they also show in this study that blocking the protein with an antibody in mouse cell experiments will restrain the ability of the cell death protein to kill normal bone marrow cells, the researchers suggest that a therapy that could disable 24p3 might prove useful to CML patients when combin...Giving children access to drug clinical trials is crucial, clofarabine approval shows
...alled a purine nucleoside antimetabolite, works by blocking the production and repair of DNA, the building blocks of genes. The drug was developed to improve the efficacy and minimize the toxicity of two similar drugs, cladribine and fludarabine. The other author of this paper is Peter Kirkpatrick (Nature Re...New GP contract may not improve treatment for heart failure patients
...ng enzyme inhibitor (ACEI) or angiotensin receptor blocking drugs (ARB) fall well short of ensuring the implementation of best practice, partly because they do not include the use of a number of other important treatments such as Beta blockers. Around four fifths of doctors said two of the indicators w...Molecular change occurring during brain tumor progression also evident in breast cancer
...mor cells' ability to invade neighboring tissue by blocking the expression of the laminin-8 gene. "Like malignant brain tumors, primary and metastatic breast tumors depend on angiogenesis, the tumor-driven creation of new blood vessels. Now we have found that similar molecular changes happen in highly vascula...Two studies offer clues about how alcoholic behavior is 'switched' on
...e second study, Thanos' group tested the idea that blocking the activity of another kind of dopamine receptor,...ist" -- a chemical that binds to the receptor thus blocking dopamine's ability to bind and send its pleasure/reward signal. The two higher doses of the antagon...New kidney cancer drug response rate is more than double that of standard treatment
...ne kinase inhibitor, which works by simultaneously blocking two growth factor receptors, a vascular endothelial growth factor receptor, and a platelet-derived growth factor receptor. By targeting multiple receptors, SU11248 cuts off the blood supply to the tumor and destroys cellular reproduction. Physicians...Biologic therapies for bowel disease show promise in clinical trials
...is has been less defined. Anti-TNF agents work by blocking the action of the reaction that causes abnormal joint inflammation. Results from these two phase three, randomized, placebo-controlled studies show that infliximab appears effective in reducing signs and symptoms of the disease, inducing remiss...Study shows Erbitux may fight colorectal cancer after other therapies fail
... EGF gives orders for a cancerous cell to grow, so blocking EGF interferes with growth. Most colorectal cancers express EGFR, and high levels of EGFR are usually associated with more metastases and poor prognosis, Lenz explains. Cetuximab also prevents DNA from being repaired, blocks metastasis and suppresse...Arthur Frommer tells America where to stop when they need to go
...and cardiovascular side effects. Enablex works by blocking the M3 receptor that is primarily responsible for bladder muscle contraction. Enablex has been studied in 98 clinical trials involving more than 10,500 people. In clinical trials, the most frequently reported adverse events with Enablex were dry mo...Patients' favorite music during surgery lessens need for sedative
...ud to uncomfortably loud. What they found is that blocking the sounds of the operating room with white noise did not decrease sedative requirements of listening to operating room sounds. Playing music did reduce the need for sedatives during surgery. "Doctors and patients should both note that music can be ...Patients with metabolic syndrome, moderate coronary calcium have greater risk of blocked arteries
...ildup causes the artery to expand outward, without blocking the vessel, and does not cause ischemia. This occurrence is associated with a low likelihood of a cardiac event over the next few years but a relatively high long-term risk. Regardless, the calcium scan correctly identifies these patients as needi...New insights into role of tumor necrosis factor on sex hormone production in rheumatoid arthritis
...ovoking destructive inflammation. Recently, drugs blocking the action of TNF have shown promise in the early treatment of rheumatoid arthritis (RA). To expand the understanding of TNF's function in chronic inflammatory diseases, researchers at University Hospital Regensburg in Germany and the National Inst...Discovery may prevent life-threatening wasting disease in patients with chronic kidney disease
...ortin 4 receptor (MC4-R) pathway in the brain, and blocking this pathway may be an important avenue for treatment, they report. The study was conducted in mice. "Understanding why patients develop cachexia is important because it is associated with very high mortality in patients with chronic kidney disease,"...New memory drug works best in combination with older remedy
... in question a compound known as SGS742 works by blocking certain chemicals that interfere with memory formation. "The findings in laboratory animals both improved memory in our tests and evidence that the drug targets the biology for making memories in the brain places this drug on solid footing as a ca...Mayo collaboration: Discovery blocks breast cancer growth, stimulates immunity
...the immune response of white blood cells. Instead, blocking T-regs boosts natural immunity. Dr. Knutson emphasized that further studies must validate these findings before they can be applied to human breast cancer patients. Even so, he says this is a welcome research advance because breast cancer is the...