Tag: "blocking" at medical news

New clues into causes of scleroderma

...h paclitaxel helps stabilize microtubules, thereby blocking the excessive activity of TGF-beta," Dong explained. "So in our latest studies, we were interested in determining whether or not paclitaxel would have any effect on tissue with scleroderma." For their experiments, the Duke team used mice bred to have...

Broccoli sprouts, cabbage, ginkgo biloba and garlic: A grocery list for cancer prevention

...age and cell mutation--and the promotion phase--by blocking the processes that inhibit programmed cell death and stimulate unregulated cell growth," said Dorothy Rybaczyk- Pathak, Ph.D., from the University of New Mexico. Pathak, along with colleagues from Michigan State University and the National Food and...

Scientists show how thinking can harm brain cells

...ansmission to reduce excitotoxic injury. "But just blocking glutamate doesn't seem to work efficiently in neurodegenerative diseases with inflammation," said Gelbard. "We reconsidered how excitotoxicity actually damages the nervous system in a functional way." The scientists focused on dendrites, the crooked ...

Albert Szent-Gyrgyi Prize for Progress in Cancer Research to Harvard's Harold F. Dvorak, M.D.

...t to show that tumor cells secreted VPF and that a blocking antibody to VPF could prevent the devastating edema and fluid accumulation characteristic of ovarian, breast, and many other human cancers. This discovery laid the foundation and also provided the molecular basis for the entire angiogenesis field and...

Engineered blood vessels may be an option in cardiac bypass

...raft surgery typically have atherosclerotic plaque blocking blood flow in one or more coronary arteries. Surgical bypass involves rerouting blood flow around blockages to deliver nutrients and oxygen to the heart. Typically, saphenous (leg) veins or internal mammary arteries are harvested from the patient a...

MabThera A unique approach providing lasting benefits for patients with rheumatoid arthritis

...ty. Traditionally, biologic therapy is focussed on blocking the action of an immune system molecule called TNF while MabThera is the first and only RA treatment to target specific types of immune cells, called B cells. B cells play a key role in the chain of inflammatory events that ultimately lead to the dam...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...Their tests in cell cultures and mice suggest that blocking the pathway by interfering with a blood cell growth gene, known as FLT3, targets an immune system cell often ignored in favor of T-cell targets in standard therapies. FLT3, which controls the development of healthy blood cells, was identified as a t...

UCSD research may lead to targeted treatment for asthma sufferers

...ive inactivation of IKK beta in the airway because blocking IKK beta throughout the body to prevent the damaging effects of asthma could also suppress the patient's immune system, resulting in infections. "An inhaled IKK beta antagonist could theoretically be designed that would not be absorbed into the blo...

Hormone aldosterone is promising target for stroke treatment

...e hormone, aldosterone, is part of the problem and blocking it may be part of the solution. Scientific momentu.... Dorrance discover what the hormone does and what blocking it prevents. In an animal model of stroke and hypertension, Dr. Dorrance and MCG graduate student Ch...

Disruption of gene interaction linked to schizophrenia

...mphetamine to stimulate release of dopamine, while blocking COMT activity with a drug called tolcapone. Blocking COMT activity significantly increased the effect of D-amphetamine in PRODH-deficient models, proving that disruption of COMT disrupts the brain's ability to rein in dopamine activity. "This geneti...

Chemical used in food containers disrupts brain development

...e said, is how inappropriate hormone signaling, or blocking the normal signaling at a critical time during development, will influence later life. In the face of more than 100 studies published in peer-reviewed journals showing the detrimental effects of BPA, Dr. Belcher said, the chemical industry and federa...

Advance in cholera bacteria points to new treatment and vaccine

... protein his research team has discovered, thereby blocking its function. This would inhibit an early step in the intestinal colonization process, and the bacteria would pass harmlessly through the body. The authors acknowledge that in addition to GlcNAc, there may be other points of attachment that could st...

Australians of the year forge partnership for burns drug development

...Phylomers appear to be very effective molecules in blocking this secondary damage that does so much harm."...

Botox for more than ironing wrinkles

...ed in treatment of hand eczema and is effective in blocking secretion of sweat, saliva and mucus in cases of Hailey-Hailey disease (a blistering disease usually treated by surgery or laser) among other ailments. In addition, "botulinum toxin A has important applications in proctology where it has become the...

New antidepressant drug increases 'brain's own cannabis'

...97 increased the production of endocannabinoids by blocking their degradation, resulting in measurable antidepressant effects. "This is the first time it has been shown that a drug that increases endocannabinoids in the brain can improve your mood," says the lead investigator Dr. Gabriella Gobbi, an MUHC and ...

Toward the future of cancer prevention

... prevent inherited colon cancer. Celebrex works by blocking cycloxygenase-2, or "COX-2," an enzyme that is over-produced when cells become inflamed. Studies have shown, however, that many tumors, including those for small-cell lung cancer, also contain a lot of COX-2, possibly because of the body's natural im...

Federal grant funds research on novel HIV therapy

... hope to achieve a triple benefit: fighting HIV by blocking the virus from immune cells, improving innate immune function and reducing symptoms of depression that are associated with the disease. Steven D. Douglas, M.D., professor of Pediatrics, chief of the Section of Immunology and director of Clinical Immu...

Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke

...ing to the EP1 receptor on nerve cells. Therefore, blocking PGE2 activity directly rather than inhibiting COX-...In addition, when the researchers injected the EP1 blocking drug ONO-8713 in mice lacking the gene for the EP1 receptor, the drug did not provide any additional...

Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe

... that do double duty by inhibiting iNOS while also blocking iNOS binding to COX-2. This would decrease the formation of both NO and prostaglandins, Snyder said. In addition to their studies in isolated cells, the team also demonstrated in mice the potential therapeutic role of drugs that block iNOS binding ...

Tool developed to silence genes in specific tissues using RNAi

... of that gene is in that particular tissue without blocking its essential functions in other tissues." In their study, Wilkinson and his research team demonstrated how well their tool worked by silencing the WT1 tumor suppressor gene in the testes of mice. They found this gene is important in the production o...

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(Date:11/7/2014)... 2014 Leading Biometric companies aim to ... revolutionizing online transactions.  Companies in focus today are: NXT-ID, Inc. ... BABA ), Google Inc. (NASDAQ: GOOG ), ... EBAY ) and MasterCard Inc. (NYSE: MA) ... a biometric authentication company focused on the growing mobile commerce ...
(Date:11/6/2014)... because of metastasis, yet progress in preventing and ... "It,s been particularly challenging to design drugs that ... in systems biology at Harvard Medical School. ... they,ve already metastasized." , Gujral and colleagues have ... researchers better understand how metastasis begins. Their findings ...
(Date:11/6/2014)... Baltimore, MD, November 6, 2014 - Insilico Medicine, ... in aging and age related diseases announced a ... medicine of cancer, Champions Oncology, Inc (OTC: CSBR). ... genomics for personalized medicine, but Champions Oncology,s TumorGraft ... can validate the chemotherapy regimen experimentally generating vast ...
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