Taking the wrinkles out of motoneuronal disease
...cies has resulted in deadly neurotoxins capable of blocking neuronal communication. I am using our knowledge of the mode of action of these neurotoxins to design a selective motoneuron delivery system that could change our way of treating motoneuronal diseases." Dr Meunier's innovative research caught the a...Protein potentially links diet, obesity and asthma
...overn metabolism. Finally, the study suggests that blocking aP2 function may be a novel approach for the treatment of asthma and other inflammatory lung diseases. ...Scientists discover why cornea is transparent and free of blood vessels, allowing vision
...ng up all the C and D VEGF growth factors, thereby blocking them from binding with VEGFR-2. And, because this binding took place in a non-vascular setting, the growth factors were neutralized. To test their theory, the team conducted a series of experiments. Using corneal tissue from mice, the team did th...Jefferson scientists show 'miracle' cancer drug Gleevec can be toxic to the heart
...ounteract this effect. In Gleevec, for example, blocking the PDGF receptor is crucial to its effect in thwarting gastrointestinal stromal tumors. Designing a drug to inhibit the PDGF receptor but not ABL, then, could still work against such tumors but not cause heart problems. "We've learned something ab...Heat therapy for cancer may be key to 'Lance Armstrong Effect'
... nuclear matrix. For example, they are looking at blocking proteins whose primary role is to act as fire blankets to coat the nuclear matrix and preserve it from heat damage. These so-called "heat shock proteins" also have a second role as "chaperones" to other proteins, ensuring their proper interaction an...Pigeons provide clue to solving common problem in heart patients
...y uses a balloon-like device to crush the material blocking an artery. But, within three to six months, even if a stent is placed in the artery to keep it open, the vessel becomes re-blocked in about 25 percent to 30 percent of patients. This process, known as restenosis, has been described as "over exuberant...Study identifies potential drug target for Huntington's disease
... HD cells below a viable energy threshold and that blocking PARP1 activation could be protective." To test ...overactivated. The next assays examined whether blocking PARP1 activity with K245-14 could reduce energy depletion in cells with the HD genetic mutation. Us...Malignant melanoma cells secrete protein required for embryo formation
...t is absent in normal skin. They also found that blocking Nodal signaling reduced melanoma cell invasiveness, as well as cancer cell colony formation and tumor-forming ability. Strikingly, nodal inhibition promoted the reversion of these cells toward a normal skin cell type. Like embryonic stem cells, mali...Diagnosis and referrals for kidney disease fall well short of need, Johns Hopkins study shows
...rting enzyme-inhibitors or angiotensin-II receptor blocking agents. Patients with hypertension, diabetes, or a family history of kidney disease are at increased risk of kidney disease. The survey was mailed to a randomly generated list of doctors between August 2004 and August 2005. The questionnaire desc...Herceptin effective in breast cancer cells with low HER-2 levels
...oratory models. Dr. Lupu has previously shown that blocking HRG expression inhibits tumor growth and spread of breast cancer cells. HRG is expressed in a significant proportion of human breast cancer biopsies and correlates with poor prognosis. Lupu and her laboratory group discovered that continuous produc...Arthritis drug helps debilitating inflammatory disease
...tem to fight disease and/or infection. It works by blocking the effects of IL-1beta (IL-1), and is approved for treating rheumatoid arthritis. Until the new NIAMS study, however, the agent had not been systematically assessed in a larger group of patients with NOMID, and its effect on the most devastating org...Clinical trial evaluates first-line approaches for treating HIV
...Is, prevent healthy T cells from being infected by blocking a process called reverse transcription that HIV uses to convert its RNA into DNA. By inserting faulty building blocks, HIV can't copy its DNA. NNRTIs, the non-nucleoside reverse transcriptase inhibitors, target the same mechanism but block the revers...Medication may promote opening of arteries following stroke
...ally occurs when a blood clot lodges in an artery, blocking blood flow to the brain. Some patients with ischemic stroke are treated quickly with intravenous recombinant tissue plasminogen activator (rtPA), which works to help dissolve the clot and reopen the artery. However, some patients do not respond to ...'Senseless' turf battles between health development and relief agencies
...hat will it take to make a topical microbicide for blocking HIV-1 transmission? A topical microbicide is a p...RJ, Moore JP (2006) Which topical microbicides for blocking HIV-1 transmission will work in the real world? PLoS Med 3(9): e351. PLEASE ADD THE LINK TO THE PU...Researchers discover how acid reflux leads to esophageal cancer
...ow down or even block the progression of cancer by blocking these different steps," Cao says. "This may have therapeutic value if we can block this particular enzyme, NOX5, in Barrett's esophageal cancer cells." Incidences of esophageal cancer related to BE have increased over the past three decades at a r...Molecular switch may turn off immune cells that target HIV
...milar role in HIV infection. They also found that blocking the pathway restores some function to HIV-specific...ive inhibitory mechanisms may play a major role in blocking T cell function. In other words, the cells may be turned off but not permanently disabled." Co-f...Yale helps organize conference to identify new treatments for Tourette Syndrome
...tions are antipsychotic drugs with potent dopamine blocking properties. These medications, however, may be associated with sedation, weight gain, and neurological effects. Other types of medications have been used with variable results. "Clearly, it is time for recent findings from cutting edge neuroscience t...Study uncovers mechanism of drug resistance in form of lung cancer
...ine at Harvard Medical School. "Drugs capable of blocking the activity of mutated T790M may be effective therapies in NSCLCs that have become resistant to Iressa and Tarceva. The key is to accurately identify patients who harbor the T790M mutation. Because the mutated gene is present in such small numbers, ...Penn study suggests a new type of pain reliever that may benefit the heart
...proxen (Naprosyn) relieve pain and inflammation by blocking the cyclooxygenases, or COX enzymes (COX-1 and COX-2). These enzymes help make fats called prostaglandins. COX-2 is the most important source of the two prostaglandins - PGE2 and prostacyclin - that mediate pain and inflammation. However, COX-2-deriv...Newly discovered behavior in cancer cells signals dangerous metastasis
... progression of tumors could lead to therapies for blocking metastasis, he said....