Tag: "blocking" at medical news
Prostate cancer treatment increases risk of diabetes and heart disease
...ipal systemic therapy for prostate cancer involves blocking
testosterone production. This is done either by removal of the testes (bilateral orchiectomy), or more commonly, by regular injections of a gonadotropin-releasing hormone (GnRH) agonist drug. GnRH agonists are the main therapy for metastatic prostate...
UCSD researchers create roadmap to integrin activation
...elets stick inappropriately, clumping together and blocking
the blood vessel. A signal from inside the platel... clots, by binding to the receptors and completely blocking
their function. However, long-term administration of similar drugs doesn't work, in part because of...
Heartburn drug may help to slow progression of chronic heart failure
.... Based on previous research, they speculated that blocking
the effects of a specific chemical released by dam...heartburn medication called teprenone. (Instead of blocking
histamine, this second medication works by causing the stomach to secret more mucous to coat and pro...
OREXIGEN reports positive 24-week results for Contrave phase III obesity treatment study
... loss, and importantly, to continue weight loss by blocking
the body's attempts to compensate for weight loss ... the brain associated with reduced appetite, while blocking
beta-endorphin, which may be responsible for limiting weight loss. We are also studying the effects ...
Cancer drug may be remedy for rheumatoid arthritis, Stanford study finds
...ss of drugs called kinase inhibitors, which act by blocking
communication signals between cells. These signals, when they go awry, are often at the root of diseases such as cancer and autoimmune conditions. Gleevec targets kinase gene mutations seen in chronic myelogenous leukemia or CML (a bone marrow canc...
New treatment for severe malaria
...ood cells, which then accumulate in large amounts, blocking
the flow of blood in the capillaries of the brain and other organs. The reason that the blood cells conglomerate and lodge in the blood vessels is that once in the blood cell the parasite produces proteins that project from the surface of the cell ...
Scientists stop colon cancer growth in mice by blocking just one enzyme
...owed up this work with animal studies showing that blocking
the production of aldose reductase halted the growth of human colon cancer cells implanted in laboratory mice. "By inhibiting aldose reductase we were able to completely stop the further growth of colorectal cancer tumor cells," said UTMB professor ...
Study unveils how West Nile virus evades immune defenses, points to vaccine development
...st Nile virus evades the body's immune defenses by blocking
immune signaling by a protein receptor, a finding that could pave the way for a vaccine to protect against North American strains of the virus, UT Southwestern Medical Center researchers report. Researchers discovered the receptor's key role in contr...
Three molecular triggers threaten leukemia patients
...he most common form of adult leukemia will require blocking
multiple molecular pathways that fuel the disease, researchers at The University of Texas M. D. Anderson Cancer Center report in the Oct. 1 edition of the journal Blood. The research team examined blood and bone marrow samples of 188 adults with acu...
Drug may help women stop smoking
...ho received the drug. Because naltrexone works by blocking
some of the effects of narcotics, such as morphine, it was originally used to treat heroin addicts. It also helps reduce relapse rates in alcoholics. Scientists suspect that it inhibits the chemical signals within the brain that convey pleasure whe...
Researchers identify new weapon to fight deadly bacterial sepsis
...aborators have discovered that in laboratory mice, blocking
the activity of a single enzyme known as aldose re...ith an aldose reductase inhibitor, they found that blocking
the enzyme's activity restored the heart's ability to pump blood normally and allowed mice injected ...
Key to lung cancer chemo resistance revealed
... including chemotherapy agents. Biswal says that blocking
NRF2 activity could improve the effectiveness of standard chemotherapy drugs, particularly platinum-based compounds widely used for lung cancer. In Biswal's study, half of 12 lung cancer cell lines and 10 of 54 tissue samples from non-small cell lu...
Cell wall of pneumonia bacteria can cause brain and heart damage
...e cells. Furthermore, the researchers succeeded in blocking
a key enzyme of this pathway in cardiomyoctyes using a molecule called PLC inhibitor U73122. The treatment prevented the cell from taking up the fragments but did not appear to interfere with the cell's normal functions. This suggests that a drug tha...
Light-sensitive photoswitches could restore sight to those with macular degeneration
...l. Green light unkinks it and replugs the channel, blocking
ion flow. Isacoff said that this same photoswitch could be attached to a variety of proteins to push or pull them into various shapes, even making a protein bend in half like a tweezer. In 2006, in a cover article in the new journal Nature Chemical...
Drug labels are prescriptions for mistakes
...orant (guaifenesin); an anti-hypertensive, channel blocking
agent (felodipine); and a diuretic (furosemide). Patient literacy was classified either as low (sixth grade and below), marginal (seventh to eighth grade), or adequate (ninth grade and higher). Study findings included: - Although 70.7 percent of ...
Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds
... loss. Finasteride interferes with this process by blocking
5-alpha reductase and preventing the conversion of testosterone to DHT. The data in The Lancet study were collected by Dr. Roehrborn from 1998 to 2000 in cooperation with medical centers in Arizona, Colorado, Connecticut, Georgia, Indiana,...
New research identifies gene important for nicotine's effects on the brain
...or both CREB activity and nicotine reward and that blocking
CREB in the nucleus accumbens was sufficient to block nicotine reward....
New study finds treatment with certain anti-hypertensive drugs may reduce Alzheimer's disease
... drug in particular was identified as effective in blocking
the accumulation of beta-amyloid in the brain and ...ion of this compound that confers the beta-amyloid blocking
benefit without affecting blood pressure. If we can give this drug at concentrations that do not ...
Research offers hope for alcoholics
...ugh a detox program and were then given the Orexin blocking
drug, did not relapse into alcohol addiction when they were reintroduced to an environment in which they had been conditioned to associate with alcohol use. "Orexin reinforces the euphoria felt when drinking alcohol, so if a drug can be developed t...
UCSD researchers discover internal compass of immune cell
... were blocked, the cells became disoriented, while blocking
A3 adenosine receptors slowed down the cell movement toward chemoattractants. The researchers also found that drugs which interfere with the amplification system impair cell migration to inflamed tissues. "These findings are very important because...
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