Cancer researchers describe gene that halts spread of aggressive childhood cancer
...h Hospital in Memphis, also describe how the gene, caspase 8, works. The findings, published in the January ... had previously shown, in normal human cells, that caspase 8 can be activated even without signals from the immune system, particularly when the cell is presen...Researchers break chain of biochemical events that brain cancer cells use to evade therapy
...cts of the overexpressed proteins, reinstating the caspase activity and the process of apoptosis. In patient trials, pioglitazone will be used instead of troglitazone, which was the ingredient in Rezulin, removed from the market because of safety issues. Pioglitazone acts in cancer cells in the same way as t...Common anesthetic may induce cell death, generation of Alzheimer's-associated protein
...eural cells increased the activation of the enzyme caspase -- a key player in a pathway leading to apoptosis ...cells that express APP and had been treated with a caspase inhibitor, the expected changes in APP processing and A-beta generation were significantly reduced, ...Study outlines how stroke, head injury can increase risk of Alzheimer's disease
... Damaged brain cells undergo apoptosis, releasing caspase which also breaks down GGA3. Without enough GGA3 ...he Neuron paper. Therapies that protect GGA3 from caspase cleaving might be able to reduce the risk of AD or the more transient type of dementia that can occu...