Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
...animals to high glucose levels. "High glucose also causes dramatic inflammatory changes in the blood vessel lining," Dr. Goldstein says. "We're working to determine whether adiponectin can also reverse these changes. This process is occurring in every patient with high blood sugars and we are hoping that ad...Mouse model points to possible new strategy for treating rare muscle disease, kidney disorders
...of the enzymes that promote sialic acid production causes low sialic acid levels in muscle proteins. They hypothesized that a compound called N-acetylmannosamine, or ManNAc, a sugar that is naturally converted to sialic acid, might have an impact on the muscle weakness caused by HIBM. To help test that hy......an, when half the control mice had died of natural causes associated with aging. This is the first time to my knowledge when an agent has been shown to extend median life span in three laboratories, says Miller, professor of pathology at the U-M Medical School and associate director of the U-M Geriatrics...Journal Sleep: Longer CPAP use at night can normalize one's daytime functioning
...er. OSA, a sleep related breathing disorder that causes your body to stop breathing during sleep, occurs when the tissue in the back of the throat collapses and blocks the airway, which prevents air from getting into the lungs. Effects of OSA include cardiovascular disease, an increased risk of hyperte...Treatment outcomes of patients with HIV and tuberculosis
...inguish between those infected with the virus that causes AIDS and those who are uninfected in terms of the optimum length of treatment when using rifamycine. "Standard 6-month therapy may be insufficient to prevent relapse in patients with HIV," said Dr. Nahid. The TB relapse rate for HIV-infected pat...TB test offers patients quicker and easier diagnosis
...of mycobacterium tuberculosis, the bacterium which causes most cases of TB. Other procedures for testing for TB are gastric washing and bronchoscopy with bronchoalveolar lavage. These invasive procedures involve placing tubes in the stomach, to collect samples of mucus swallowed during the night, or the b...OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
...ent the research. It has been known that cancer causes an inflammatory response. This research also suggests that inflammation may play an important role in driving prostate cancer progression and resistance to therapy. "While sometimes inflammation may slow the cancer, an increasing body of evidence...International studies show high efficacy for HPV vaccine
...their lives," says Dr. Ault. For most people, HPV causes no complications and goes away on its own. However, in some cases, if left untreated, certain high-risk types of HPV can lead to cervical cancer. "The goal of the study was to see if we could prevent precancerous cases and the results of this comb...Second SPORT study shows surgery advantage for spinal stenosis and slipped vertebra
...frican-American women. Although DS alone generally causes no symptoms, in some cases it can result in spinal stenosis-narrowing of the spinal canal which causes pressure on the nerves-resulting in significant pain in the legs that is worsened by simply taking a...Research shows aerobic exercise helps maintain muscle in elderly
... to the hormone's activity (as in type 2 diabetes) causes blood sugar levels to soar out of control. Recent studies have shown, however, that insulin also provides crucial assistance in building muscle, and that its ability to do so drops off dramatically in the elderly. Now, a small but provocative study...'Virtual autopsy' helps identify drowning as cause of death
...e support for the diagnosis of drowning when other causes of death have been excluded by a limited autopsy or external examination of the body. In addition, MDCT virtual autopsy may be useful as a pre-autopsy triage tool in mass casualty scenarios. "More and more, advanced imaging tools such as MDCT are b...Researchers find deadly prescription drug effects 6 years before FDA
...harmaceutical side effects are one of the top five causes of death in this country. We want to move it out of the top five. This is the way to start that process and save thousands of lives. Bennett envisions a formal partnership with the FDA in which he would share RADARs investigations on safety issues...Syphilis screening, lithium fights neurodegeneration, monoclonal antibodies against avian flu
...amine stretch in the Ataxin1 protein. This stretch causes Ataxin1 to accumulate and to have altered protein interactions that are toxic to a group of cerebellar neurons called Purkinje cells (which normally coordinate movement) and hippoca mpal neurons (which are important for memory). Patients gradually lo...Most pediatric chemotherapy mistakes reach patients
...s to characterize the patterns of errors and their causes for children receiving chemotherapy. Between 1999 and 2004, 829,492 errors were reported, of which 29,802 involved patients under 18 years old and 310 of these involved a chemotherapeutic drug. The authors of the study found that 85 percent of thes...Steps needed to reduce smoking in the US
...out 440,000 lives every year, and secondhand smoke causes another 50,000 deaths annually. Smoking-related health costs are estimated to be $89 billion a year. The report proposes a two-pronged approach to further reduce tobacco use in the United States. The first element focuses on strengthening exist...What exactly is repetitive strain injury?
...y is that overuse of tendons by repetitive loading causes RSI. Diagnosis is often a difficult proposition. The authors say: "No gold standard tests for repetitive strain injury exist. In most cases, diagnosis is made on the basis of history and physical examination, including assessment of range of motio......It's a challenging disease to live with because it causes frequent and difficult urination. Unfortunately, common treatments also are problematic because they carry some risk of serious side effects, such as impotence. Our results are encouraging because they indicate that Botox could represent a simple, sa...Malaria 2007 -- Progressing research, persisting challenges
... individuals live in areas of risk and the disease causes more than 1 million deaths annually. Even in the United States, where endemic malaria has been eradicated for decades, an average of 1,200 cases are reported annually. The articles in this issue of JAMA on malaria address a number of important issues...Certain combination therapy found more effective for treating malaria in African children
... issue on malaria. Malaria is one of the leading causes of death in children in Africa. One of the reasons the control of malaria has been difficult is because of increasing resistance to some drugs, leading to changes in antimalarial treatment recommendations, according to background information in the a...UW study to clarify safety, effectiveness of hormone therapy during menopause
...oved that women should not use estrogen because it causes breast cancer and has no benefits for cardiovascular disease. Today, researchers understand that the WHI was not designed to address younger women entering menopause. "There has been a tremendous amount of important and valuable research done on ...