Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
...es abound about the mechanisms of retinal ganglion cell damage in glaucoma, but no single cellular or molecular cause satisfactorily explains the condition in all patients, Dr. Caprioli writes. Long-term variability may disrupt homeostatic mechanisms. Irregular and large IOP fluctuations may cause a loadi...Stomach cancer rate set to fall further 25 percent over next decade
... on the long term monitoring of the three types of cell changes indicative of subsequent stomach cancer. The authors tracked all new cases of atrophic gastritis, intestinal metaplasia, and dysplasia recorded in the Dutch national registry of diseased tissue samples. The monitoring period covered the y......eric Geissmann and colleagues find that Langerhans cell accumulation in Langerhans cell histiocytosis results from survival rather than uncontrolled proliferation, and is associated with t...Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
...ome shorter. When they become too short, the aging cell can no longer divide, Dr. Souza said. Scientists suspect that when cells can no longer divide, other cells might infiltrate the area to make up for the loss. And those cells may be more likely to generate the acid-resistance that makes them more li...New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
... are changed and new side effects develop. When cell lines changed from being sensitive to endocrine th...al anti-apoptotic genes responsible for programmed cell death including BCL2 are altered. While they have not yet determined the exact interactions that t...Penn study finds pro-death proteins required to regulate healthy immune function
...Medicine have found that proteins known to promote cell death are also necessary for the maturation and pr... a calcium-mediated signaling pathway that ends in cell differentiation and growth. The Penn scientists discovered that in the cells that lack the pro-death...Chromatin remodeling complex connected to DNA damage control
... A cell's DNA resides in chromosomes found in the cell nucleus, but it's a bit more complex than just DNA...e cells were stuck in a checkpoint pause, blocking cell division. When phosphorylation was blocked, the cells' response to replication stress was impaired, ...Pathway links inflammation, angiogenesis and breast cancer
...ug, temsirolimus, has been approved to treat renal cell carcinoma. Hung's lab is exploring the possibili...binding preference to the NF"B oncogene, promoting cell growth. Unphosphorylated CBP helps p53 do its job suppressing cancer by forcing defective cells to k...Reductive stress linked to heart disease
...ins fold inside cells. When it works properly, the cell produces the correct amount of reduced glutathione, which is healthy for the body. Unfortunately, when the gene that makes alpha B-Crystallin is mutated in humans, the protein unfolds improperly into aggregrates, the hallmark of the condition in diff...Stanford researchers find culprit in aging muscles that heal poorly
...aling pathway would have a negative effect on stem cell function." Rando, who also does research and clini... studying the effect of environment on muscle stem cell activity in mice. Rando had already discovered that old muscle stem cells, if placed in a youthful e...NIH scientists target future pandemic strains of H5N1 avian influenza
...ains are isolated and then grown inside eggs or in cell cultures. The virus is then collected, inactivated...nd enter human cells. Bird-adapted H5N1 binds bird cell surface receptors. But these receptors differ slightly from the receptors on human cells, which in p...'Heroes of Chemistry' honored for medical, energy, environmental breakthroughs
... as thalassemia, myelodysplastic syndromes, sickle cell disease and other anemias. Tens of thousands of children and adults around the world have these diseases. For many, the need for transfusions and chelation are life-long. A single dose of Exjade works throughout the entire day, removing excess iron -...Stem cell transplantation procedure results in long-term survival for amyloidosis patients
...e found that high-dose chemotherapy and blood stem cell transplantation can result in long-term survival f...who received high-dose chemotherapy and blood stem cell transplantation from July 1994 through July 1997. The median survival for all 80 patients was 57 mo...Miniature implanted devices could treat epilepsy, glaucoma
...mitter. "The idea is that by using an engineered cell to release a neurotransmitter, we have a drug pump, in essence, that automatically refills itself and that only impacts the part of the brain where the living electrode is implanted: the epileptic focus," Irazoqui said. "So you are not going to get t...Green tea holds promise as new treatment for inflammatory skin diseases
...en tea also showed reduced levels of proliferating cell nuclear antigen, a gene expressed when skin cells ... lesions and be used long term, may cause squamous cell carcinoma the second most common form of skin cancer, Dr. Hsu says. Some of the most effective anti...To be or not to be a scientist
...to research topics ranging from diabetes to sickle cell anemia....Electric fields have potential as a cancer treatment
...the researchers have shown that the fields disrupt cell division in tumor cells placed on a glass dish (in...ects on the tumor cells. First, they slowed down cell division. Cells that ordinarily took less than an hour to divide were still not completely divided a...Study shows radiofrequency ablation highly effective in treating kidney tumors
...ents, a biopsy had confirmed the presence of renal cell carcinomas (RCC), a common type of renal malignanc...ly been adapted for treatment of RCC. Renal cell carcinomas that are smaller than 3.7 cm in diameter can be reliably and safely eradicated with percu...Shining light on pancreatic cancer
...ithout hitting deeper unaffected cells and to scan cell structures on the scale of nanometers, smaller than a doctor can see with a microscope. "Contemporary diagnostic medicine frequently relies on invasive procedures, such as endoscopy, to detect disease. In the fictional world of Star Trek, a doctor ...Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
...signals inside cells to regulate such functions as cell growth, cancer development and programmed cell death. The work suggests that drugs designed to disable the enzyme, known as TOPK, could have anti-c...