New mechanism identified for resistance to targeted lung cancer drugs
...s with the sensitizing EGFR mutation and created a cell line resistant to treatment with Iressa. In a num...ne with still-sensitive cells, they focused on the cell signalling pathway controlled by EGFR. In earlier research, Engelman and colleagues had found that ...New biotech company to commercialize novel UD gene-repair technology
...hat cause rare, hereditary diseases such as sickle cell anemia and spinal muscular atrophy. The announce...o introduce a tiny fragment of DNA into a diseased cell to replace the defective portion, triggering the cell to heal itself. This method, which focuses o...Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
...eakdown are also known to trigger inflammation and cell death. Together, these facts compellingly suggest that SMase plays a critical role in the heretofore mysterious pathogenesis of lung injury in CF patients. They also present a new paradigm for treating CF. Specific inhibitors against the enzyme, i...NeuroArm: Navigating the future of surgery
...ate, and shifts surgery from the organ towards the cell level." Designed to be controlled by a surgeon from a computer workstation, neuroArm operates in conjunction with real-time MR imaging, providing surgeons unprecedented detail and control, enabling them to manipulate tools at a microscopic scale. A...UCSF brain tumor vaccine trial shows promising results
...r both metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). Reviewing the presentation at AANS, Henry Brem, MD, director of neurosurgery at the Johns Hopkins Medical Institutions, noted, This is an encouraging study of a therapeutic cancer vaccine that targets multiple tumor anti...Researchers discover gene crucial for nerve cell insulation
...kening. The myelin sheath that surrounds a nerve cell is analogous to the insulating material that coats an electrical cord or wire, keeping nerve impulses from dissipating, allowing them to travel farther and faster along the length of the nerve cell. The researchers discovered how a defect in just o...Diet and lifestyle -- In the cancer fight, eating well is the best revenge
... metastasize to. When breast and ovarian cancer cell lines are exposed to purified DIM or genistein, le... the lower compartment, a system that represents a cell culture model for invasiveness," she said. But if the cells are treated with either DIM or geniste...Experimental flu vaccine appears promising in early tests
... recombinant DNA techniques to express proteins in cell culture has been a successful approach for generation of highly effective vaccines for the prevention of hepatitis B virus and human papillomavirus. Among the available expression technologies, recombinant baculovirus is especially well suited for pr...Bypassing eggs, flu vaccine grown in insect cells shows promise
...he virus to grow as you want in eggs. The use of cell culture systems to grow vaccines using viruses as...growing business. A similar technology using human cell lines is used to produce the hepatitis B vaccine, while one form of a vaccine against human papillom...Study suggests use of stem cell transplantation is beneficial treatment of type 1 diabetes
A therapy that includes stem cell transplantation induced extended insulin independe... by autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) to preserve beta-cell function in 15 newly diagnosed patients with type 1 DM....Fragile X, Down syndromes linked to faulty brain communication
...tigators relied on a strain of mice in which every cell carried a mutated Fmr1 gene, and they inferred how cells communicated by results from experiments on groups of cells. The new approach allowed Madison's team to see that cells with a mutated Fmr1 gene have a very selective flaw: they are less likel...ACS News Service Weekly PressPac -- April 4, 2007
...y aroma, have no detectable toxicity in laboratory cell cultures, aside from causing a slight aggravation of the immune response that could affect people with allergies. That is the conclusion of a new study done by scientists in Germany and scheduled for publication in the current (April 1) issue of ACS ...Drug used to prevent HIV transmission from mother to child damages DNA
...ne the blood vessels) in male mice and mononuclear cell leukemia in female rats. There was also some evidence of increased liver cancer and reproductive tumors. "Although the implications of these findings for the long-term health of human children exposed tranplacentally to AZT are uncertain, the possi...Row over study puts Korea's scientific community under scrutiny again
...ke of the recent scandal over Woo-Sok Hwang's stem cell research. Dr Kim claims a paper about premature ...everely damaged reputation and credibility of stem cell and life science research in Korea after the Hwang scandal." Professor Kim's intervention leaves l...Rush researchers participate in worldwide AIDS initiative led by Imperial College London
...asure CD4+ T-lymphocytes in HIV+ patients. The CD4 cell count measures the number of these critical disease-fighting cells in the blood, a figure that health care workers need in order to make key clinical decisions in managing HIV disease, such as when to begin or to switch antiretroviral therapy. Stud...A sweet step toward new cancer therapies
...gars called glycans attached to proteins on cancer cell surfaces as accomplices in the growth and spread of tumors. Researchers have been keen to characterize these glycans, but traditional analytical methods have not been sufficient. Now, Hakansson's research group has demonstrated that their technique...Radiofrequency ablation effective treatment for inoperable lung cancer
...nd five-year survival rates for stage I, non-small cell lung cancer treated with RF ablation were 78 percent, 57 percent, 36 percent, 27 percent and 27 percent, respectively. A recent study reported that patients with similar cancers who underwent conventional EBT had a three-year survival rate of 34 perc...Rhode Island Hospital study confirms RF ablation effective for treating inoperable lung cancer
...s." Other survival rates for stage I, non-small cell cancer treated with RF ablation were 78 percent for one year, 57 percent for two years, 36 percent for three years and 27 percent for both four and five years. ...Stem cells speed growth of healthy liver tissue
...ients who received the combination of PVE and stem cell injection had double the liver growth rate and gai...ed on our results, we also believe that adult stem cell administration may be a promising therapy for regenerating livers damaged by other chronic and acute...Blocking immune cell action increases Alzheimer's-associated protein deposits
...ired for recruitment of the brain's primary immune cell led to increased amyloid-beta deposits and earlier... lead author. "This new connection between immune cell function and this debilitating disease suggests potential new therapeutic strategies." While it h...