Pezcoller Foundation-AACR International Award for Cancer Research
... would allow the cell to continually grow and make copies of itself, resulting in a cancerous tumor. Research over the past decade by numerous laboratories has supported this model and provided evidence that PI3K plays a critical role in many human cancers. In addition, research from Cantley's laboratory...Fifteen-year hunt uncovers gene behind 'pseudothalidomide' syndrome
... techniques they used -- such as that to make many copies of DNA from a small sample -- have been around in ... cell to move them together, ensuring that the two copies are lined up together at the center of the dividing cell. Once lined up, tiny molecular "motors" att...Institute of Medicine advisory: Cord blood stem cells
...y of the inventory of banked cord blood. Advance copies will be available to reporters only beginning at noon EDT on Wednesday, April 13. THE REPORT IS EMBARGOED AND NOT FOR PUBLIC RELEASE BEFORE 4 P.M. EDT ON THURSDAY, APRIL 14. Reporters can obtain a copy by contacting the National Academies' Office o...Institute of Medicine advisory: April 19 public briefing on HIV/AIDS crisis abroad
...r, 500 Fifth St., N.W., Washington, D.C. Advance copies of the report will be available to reporters only ...ORE 1 P.M. EDT ON APRIL 19. Reporters may obtain copies or register to attend by contacting the National Academies' Office of News and Public Information at...Genetic screening for iron blood disorder feasible in the workplace
...online today by THE LANCET. People who inherit two copies of a mutation in a gene called HFE are predisposed...utation and identified 47 participants who had two copies of the mutation and 1338 individuals who had one copy of the mutation. 46 of the 47 newly identified...'Surprising' findings reported about iron overload
... had the highest prevalence of persons who had two copies of the C282Y mutation of the HFE gene (4.4 per 1,000 people). Prevalence of two copies of the C282Y mutation of the HFE gene in other racial/ethnic groups were: Native Americans (1.1 per ...Study of iron overload yields surprising results
...e highest prevalence of the C282Y mutation in both copies of their HFE gene (4.4 per 1,000 people). Though this is the gene combination most likely the result in hemochromatosis, the risk of developing symptoms is less than 60 percent. The prevalence rates of this combination in other ethnic groups were: N...Northwestern's cancer genetics program ID's gene variant that increases colon cancer risk
...tion in these genes. The number of carriers of two copies of the TGFBR1*6A gene was 13-fold higher than in the general population, suggesting that TGFBR1*6A homozygosity (possessing two identical forms of a particular gene, one inherited from each parent) is associated with a particularly high risk of color...Blocking the Odc gene is effective in preventing cancers
...uppressing drug DFMO or the loss of one of the two copies of the Odc gene in a B lymphocyte impairs Myc's ability to stimulate uncontrolled cell division. The team made these findings in E-Myc laboratory models, which overexpress Myc in B cells and are widely used in laboratory studies of cancer. The disco...Genes may influence nutritional composition of breast milk
...y found that mothers who carried either one or two copies of the E4 variant had 40 to 75 percent less total fat in their breast milk compared to women who did not have the variant. "This unexpected finding suggests that the E4 variant could affect the total amount of calories that a mother can provide to he...Testicular cancer gene in mice may offer clues to origins of cancer in men
...f the cancer results when the infant has lost both copies of his dead end gene." The researchers theorize that testicular cancer that develops in young adults may also originate from a genetic mutation during fetal development - perhaps by inheritance of a single dead end mutation - and tumor development oc...Genomics researchers discover protein deficit that causes drug toxicity
...s of Caucasian European genetic background has two copies of the variant gene -- specifically, a switch in 2 out of 245 amino acids -- that results in the absence of the protein needed to properly metabolize thiopurine drugs. In patients with the genetic defect, instead of helping heal, a standard dose of t...Study: Nose doesn't smell like the eyes see
...nsitivity." For example, the cells could have many copies of the receptor, or many cells could express the same receptor. These are most likely the reasons why mice and dogs have a heightened sense of smell compared to people, says Yau....SCAI news: Drug-eluting stents prove mettle in heart attack patients
...articles, or call 717-241-2470 or 717-422-1181 for copies of the articles themselves. Drug-Eluting Stents Prove Mettle in Heart Attack Patients Interventional Cardiologists and Patients Can Be Confident in New Treatment Choice (BETHESDA, MD)--Drug-eluting stents are a safe and effective treatment for h...National Academies advisory: Release of Coeur d'Alene superfund report
...ginning at noon EDT on Thursday, July 14. Advance copies of the report will be available to reporters only beginning at 3 p.m. EDT on Wednesday, July 13. THE REPORT IS EMBARGOED AND NOT FOR PUBLIC RELEASE BEFORE NOON EDT ON JULY 14. To obtain a copy or to register to participate in the telephone news con...Animal disease reports to be released at July 18 news conference at AVMA convention
...relations, AVMA, at sgranskog@avma.org . Advance copies of the reports will be available to reporters only beginning at 8:30 a.m. CDT on July 18. THE REPORTS ARE EMBARGOED AND NOT FOR PUBLIC RELEASE BEFORE 1:30 P.M. CDT ON JULY 18. To obtain copies, contact the National Academies' Office of News and Pub...Hepatitis C responds best to combo of ribavirin and interferon, study concludes
...s andinhibiting the ability of viruses to make new copies of themselves andproliferate. Ribavirin belongs to a class of drugs called nucleoside analogues, whichincludes some anti-HIV drugs such as AZT (zidovudine). Ribavirin usedalone does not have any effect on HCV but in combination with interferonit appe...Penn study shows genes may affect response to different quit-smoking medications
...on). The research team found that smokers with two copies of the DRD2 -141 Ins C variant were significantly more likely to be abstinent at the six-month follow-up if they used Zyban©, as compared to smokers carrying the Del C variant. By contrast, smokers carrying the Del C variant had significantly hi...Defective lymphatic vessels identified as a novel cause of adult-onset obesity
...nvestigators showed that removal of one of the two copies of the gene Prox1 disrupts normal development of t...The laboratory model (Prox1+/- ) lacked one of two copies of the Prox1 gene, which is required for proper development of the lymphatic system. Previously, Oli......PAX7-FOXO1a. Translocation destroys one of the two copies of FOXO1a, Grosveld noted. If the remaining FOXO1a gene then fails to produce FOXO1a protein, the combination of the absence of FOXO1a with the gene translocation causes ARMS. The finding suggests that drugs aimed at restoring or increasing the acti...