Tag: "crohn" at medical news

FDA grants priority review of Remicade® for children with Crohn's disease

HORSHAM, Pa. - Centocor, Inc. announced today that the supplemental Biologics License Application (sBLA) for REMICADE (R) (infliximab) for the treatment of pediatric Crohn's disease has been accepted and designated for Priority Review by the U.S. Food and Drug Administration (FDA). Centocor is seeking approval for the treatment of moderately to severely active pediatric Crohn's disease in patien...

ECP may be effective in treating Crohn's disease

(Washington, DC - May 23, 2007) -- Results from an international multi-center Phase II clinical trial suggest that extracorporeal photopheresis (ECP) may be effective in treating patients with clinically active (OR symptomatic) Crohns disease who cannot tolerate or are refractory to immunosuppressants and/or anti-TNF agents. A 50% response rate after 3 months of ECP treatment was noted in the s...

Smoking influences Crohn's disease

... "In patients who smoke, Crohns disease tends to appear more frequently in the small intestine, rather than the colon," says study author Dr. Marian Aldhous. "Our data shows that when Crohns disease is located here, it tends to cause more penetrating or obstructive dama...

Researchers identify new therapy for patients with Crohn's disease

... Crohns disease is an inflammatory disorder of the gastrointestinal tract that affects an estimated 500,000 people in the United States. Symptoms include abdominal pain, fever, nausea, vomiting, weight loss and diarrhea. Crohns disease has no known medical cure. One common therapy is a series of intravenous infusions of i...

Canada high in ulcerative colitis and Crohn's cases: Is Canada too clean?

... ... IBD is a wearing away of the lining of the intestinal tract until it becomes red and raw and begins to bleeds, like a skinned knee. The difference between ulcerative colitis and Crohn's disease is where t...

Penn State research shows withdrawal drug offers relief for Crohn's sufferers

A Penn State College of Medicine pilot study suggests that a drug used to ease symptoms of alcohol and drug addiction may also bring relief to people with Crohn's disease, a chronic inflammatory disorder of the intestine that affects an estimated 500,000 Americans....... In the study, patients with diagnosed Crohn's disease were treated with a low dose of naltrexone, an FDA-approved drug used to...

Immune signals of variations of a single gene linked to more severe Crohn's disease

LOS ANGELES− Building on previous evidence supporting the theory that the pathophysiology of Crohn's Disease is altered by genetic variation, recent studies have found that the combination of immune signals given by three variants of a single candidate gene affects the severity of the disease, particularly among Ashkenazi Jews. The findings, presented at the annual meeting of the American...

Biologic therapies lead evolution of Crohn's treatments

LOS ANGELES (May 22, 2006) A variety of diseases are now treated with biologic therapies, which are derived from human tissues, because of their ability to target specific causes of inflammation compared with the general immunosuppressive effects of the chemical-based compounds that make up current therapies. In research presented today at Digestive Disease Week 2006 (DDW), several biologic th...

Crohn's & Colitis Foundation of America selects Wiley to publish Inflammatory Bowel Diseases

Global publisher John Wiley & Sons, Inc., announced today that it has been selected by the Crohn's & Colitis Foundation of America (CCFA) as the new publisher of the Foundation's official journal, Inflammatory Bowel Diseases, effective January 2007....... Inflammatory Bowel Diseases is the first and only peer-reviewed journal dedicated exclusively to inflammatory bowel diseases. Now in its tenth...

New insight into cause of Crohn's disease

UK scientists have found evidence that suggests Crohn's disease is caused by a weak immune response. The researchers, who report their findings in an Article in this week's issue of The Lancet, also suggest that sildenafil (Viagra) might help in the treatment of the disease....... Crohn's disease is a chronic inflammatory disorder that causes ulcerations in the small and large intestines. Many s...

Improved diagnostic technology for Crohn's disease

The diagnostic value of CT enteroclysis is superior to conventional enteroclysis, previously considered the gold standard, as an imaging method for the evaluation of the small bowel in patients with Crohn's disease, a new study shows.... ...Crohn's disease is an inflammatory disease of the intestinal wall. Complications of Crohn's disease, such as abscesses, and stenoses, are found in approximate...

UVa Health System wins renewal of $6.2 million grant for Crohn's disease research

CHARLOTTESVILLE, Va., Oct. 20, 2005-- A federal grant to The Digestive Health Center of Excellence at the University of Virginia Health System to study the cause of Crohn's disease has been renewed for another five years. The $6.2 million grant from the National Institutes of Health (NIH) came after a competitive review process. It will allow UVa to continue groundbreaking work using a mouse mod...

Gaps in intestinal barrier could cause Crohn's disease

LIVERPOOL, UK 15 September 2005: Scientists at the University of Liverpool believe gaps in the intestinal barrier could be a cause of inflammatory diseases of the gut such as Crohn's Disease. ...... Their research, led by Professor Alastair Watson in the University's Faculty of Medicine, could have important implications for the treatment of patients with diseases like Crohn's an inflammatory b...

Immune factor GM-CSF significantly improves Crohn's disease symptoms

A drug that stimulates a specific part of the immune system may improve symptoms of Crohn's disease, according to a study in the May 26 New England Journal of Medicine. A multi-institutional research team reports that treatment with the growth factor GM-CSF significantly reduced symptom severity and improved quality of life after 56 days of daily drug injections. The finding supports a new conc...

Enhancing innate immunity improves Crohn's disease symptoms

St. Louis, May 25, 2005 -- Like throwing oil on a fire or prescribing a high cholesterol diet for heart patients, gastroenterologists traditionally have believed that it would not be a good idea to stoke up the body's immune system to treat Crohn's disease. Most treatments for Crohn's, an autoimmune disorder, are geared to suppress the immune response, but a new study demonstrates that stimulatin...

Small, open-label study shows potential use of novel antibiotic rifaximin for Crohn's disease

New York, NY (May 18, 2005) A small, open-label study conducted by physicians at NewYork-Presbyterian Hospital/Weill Cornell Medical Center suggests that there may be a new application for the novel antibiotic rifaximin in treating patients who suffer from severe Crohn's Disease and who have not responded to all other available medications for the disease. ... The study was conducted by Dr. Elle...

MMR vaccine does not increase risk of Crohn's disease

The measles, mumps, and rubella (MMR) vaccine does not increase the risk of Crohn's disease (chronic inflammation of the intestine), finds a study in this week's BMJ....... It has been hypothesised that the MMR vaccine increases the risk of Crohn's disease, although the evidence for this is sparse. The study provides strong evidence against this theory and adds to the evidence that MMR vaccine i...
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