Tag: "cytokines" at medical news
New compound stops brain cell degeneration in Alzheimer's disease
...its production of pro-inflammatory proteins called cytokines
by glia, important cells of the central nervous sy...proof of concept that targeting over-production of cytokines
by activated glia is a viable approach that has the potential to modulate disease onset and progress...
Obesity is a significant predictor of periodontal disease
... "People who have a higher body mass index produce cytokines
(hormone-like proteins), that lead to systemic inf...ronic stimulation and secretion of proinflammatory cytokines
associated with periodontal infection also occurs, contributing to insulin resistance, which may fur...
Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection
... engineered neural stem cells to transport several cytokines
proteins that regulate immune responses to track... in an immune response to tumor cells. The earlier cytokines
produced good results, but IL-23 is even more potent," Yu said. "Most anti-tumor gene strategies att...
Major biomarker candidates for Alzheimer's disease explored
...in (University of Arkansas) review proinflammatory cytokines
as potential markers for AD, pointing out in "Inflammatory biomarkers in Alzheimer's disease" the difficulties in the use of such markers due to complicating genetic factors. Finally, Jing Zhang, David R. Goodlett, and Thomas J. Montine (University o...
Bone resorption cells offer drug targets for osteoporosis, rheumatoid arthritis, and more
...he interaction of osteoclasts and the inflammatory cytokines
produced by the immune system. Dr. Teitelbaum's g...ny of the indirect and direct means by which these cytokines
cause joint destruction and are pinpointing targets for drugs to prevent this loss. HIV/AIDS. ...
Fat cells around coronary arteries may play a role in heart disease
...greater amounts of harmful, inflammation-producing cytokines
in response to certain stimuli. Epicardial adipocytes (but not adipocytes from subcutaneous or renal fat) strongly induce coronary artery endothelial cells to form elongated, branching structures indicative of blood vessel formation (angiogenesis)...
A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases
...l. "It is possible that for most of human history, cytokines
like IL-25 have promoted type 2 T helper cells that fight infection with intestinal parasites like Trichuris, " said Colby Zaph, a co-author and Irvington Research Fellow at Penn. "In industrialized countries, where worm infections are now rare, thi...
Urgent changes needed for authorisation of phase I trials
..."Despite the recognised risk of massive release of cytokines
that is clearly described in the product dossier and investigator's brochure, there is no mention in the published documents of any precautionary dosing interval between volunteers. As the Academy of Medical Sciences suggests: 'it would be usual prac...
H5N1 threat puts human flu back in spotlight
...ne cells spewing out inflammatory chemicals called cytokines
in a "cytokine storm" that causes airways to become inflamed and the alveoli to fill with fluid. The result can be rapid death. According to the investigators, this finding at least partially explains why so many young, otherwise healthy people succu...
Men face rising osteoporosis risk
... keep bone-depleting inflammatory compounds called cytokines
in check. Without sufficient estrogen, cytokines
strip away at bone layers through a process called resorption. Over time, weakening bones develop th...
Health risks continue well after the surgery is over
...d with an overwhelming release of pro-inflammatory cytokines
that are harmful to the host." The mice die rapidly and these re-programmed macrophages may help explain why children with sickle cell disease are more prone to overwhelming and potentially deadly infections following surgery. "We need more investiga...
Montreal researchers identify defects of immune cells
...howed extensive perturbations in the production of cytokines
required for protection against oral candidiasis in the transgenic mice. "These findings regarding the specific immune defects which trigger candidiasis are very promising," explains Dr. de Repentigny. "This new knowledge will be instrumental in desi...
Rheumatoid arthritis patients can benefit from Enbrel in combination with methotrexate
...sis factor (TNF), one of the dominant inflammatory cytokines
or regulatory proteins that play an important role in both normal immune function and the cascade of reactions that causes the inflammatory processes of rheumatoid arthritis. The binding of ENBREL to TNF renders the bound TNF biologically inactive, ...
JCI table of contents: July 3, 2006
... associated with the release of molecules known as cytokines
that stimulate the growth of new blood vessels to ... and regulate the myocardial balance of angiogenic cytokines
AUTHOR CONTACT: Alex Radkewycz Public Affairs, Toronto General Hospital, Toronto, Ontario, Canada. P...
Exam nerves affects students' immune defense
...rations of a group of inflammation products called cytokines
had changed and shifted against a pattern associated with allergic inflammation in the allergic students, but remained normal in the healthy students. According to Mats Lekander and Caroline Olgart Hglund, who are leading the research group, the t...
Molecular switch may turn off immune cells that target HIV
...nfection by reproducing dramatically and producing cytokines
that help destroy the viruses, but in chronic infection high levels of virus appear to overwhelm and exhaust CD8 cells. Recent studies in mice by Rafi Ahmed, PhD, of Emory University School of Medicine and Gordon Freeman, PhD, of Dana-Farber Cancer ...
New data reinforce safety profile of ENBREL (etanercept)
...is factor (TNF),3 one of the dominant inflammatory cytokines
or regulatory proteins that plays an important role in both normal immune function and the cascade of reactions that causes the inflammatory processes of psoriasis, psoriatic arthritis and RA.3 The binding of ENBREL to TNF inhibits the activity of t...
Mayo Clinic discovers potential link between celiac disease and cognitive decline
...Murray: Nutritional deficiency Inflammatory cytokines
-- chemical messengers of inflammation that could contribute to problems in the brain An immune attack on the brain that may occur in some patients with celiac disease The cognitive decline that occurred in three of the celiac disease patients...
Bank on a Cure researchers identify pathways mediating myeloma treatment side effects
...n achieved by thalidomide that can in turn release cytokines
and other tissue factors, which increase the risk of thrombosis, or clots. The genes were validated using a custom panel of 3,404 SNPs developed by BOAC working with Affymetrix. Brian G. M. Durie, M.D., chairman of the International Myeloma Founda...
Could the ability to expel worms lead to a future asthma treatment?
...blood cell that secretes protein messengers called cytokines
to accelerate the immune response. According t...Type 1 (Th1) and Type 2 (Th2), each defined by the cytokines
they produce. Each profile is more effective at attacking certain invaders, with Th1 responses, for ...
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