Tag: "deficiency" at medical news
Six organizations vie for INFORMS 'science of better' innovation prize
...lopment of ALIMTA began collecting patient vitamin deficiency
markers and using operations research methods to identify severe toxicities, allowing researchers to quantify the relative risks. As a result, the safety of ALIMTA was profoundly improved. In 2004, ALIMTA was approved both in the U.S. and the Europe...
Maternal iron deficiency disrupts mother/child interaction
...artum depression and that women with moderate iron deficiency
have a slow down in thinking and memory. Our new results suggest that the effects of mild iron deficiency
-- which are easily correctable with supplements -- can disrupt the solid foundation that is establi...
'Fickle' enzyme helps protect, but also can promote heart failure, animal study shows
...e genetic disorder in children that results from a deficiency
in the enzyme phenylalanine hydroxylase. Loss of this enzyme can lead to mental retardation, organ damage and unusual posture. Cardiac hypertrophy commonly develops from high blood pressure, which forces the heart to pump harder to circulate blood t...
Study concludes primary IGF-1 deficiency is a frequent cause of short stature
...cient primary insulin-like growth factor-1 (IGF-1) deficiency
(Primary IGFD) is a frequent cause of short statur...oting hormone, IGF-1. Children with growth hormone deficiency
typically have low blood levels of IGF-1. IGF-1 plays a principal role in stimulating growth and its...
Iodine deficiency, supplements affect thyroid cancer risk in children exposed to radioactive iodine
...d risk of thyroid cancer. Importantly, both iodine deficiency
and supplementation appear to modify this risk, ac...acuated after the Chernobyl accident. "Both iodine deficiency
and iodine supplementation appear to be important and independent modifiers of the risk of thyroid c...
Umbilical cord-blood transplants save lives of babies with rare genetic disorder
... in about one in 100,000 births. It is caused by a deficiency
of the enzyme galactocerebrosidase, or GALC, which leads to a loss of myelin, a fatty covering that wraps around and protects nerve fibers in the brain. Without myelin, nerves in the brain and other parts of the body cannot function properly. Previou...
Bad metabolism in blood vessels linked to high blood pressure and atherosclerosis
... the results of this study, Semenkovich believes a deficiency
in essential fatty acids may cause changes in the way metabolism occurs in the blood vessel wall. "It would be interesting to figure out how to take essential fatty acids, get them into the vessel wall and see if you could treat atherosclerosis that...
New insights into role of tumor necrosis factor on sex hormone production in rheumatoid arthritis
...s with OA." Providing the full picture of androgen deficiency
in RA, this study affirms the need for further research into early anti-TNF antibody therapy in the treatment of this particular inflammatory disease....
Tercica presents pharmacokinetic and safety data from several studies at Endocrine Society Meeting
... treatment of short stature caused byprimary IGF-1 deficiency
(Primary IGFD). The NDA was accepted for priorityreview by the FDA on April 29. Data presented include: results from a human pharmacokinetic study; resultsfrom a novel diagnostic test used to distinguish children who may beinsensitive to the effects ...
Study shows new method of growth hormone dosing improves height
...ldren who have short stature due to growth hormone deficiency
and idiopathic short stature. The groundbreaking s...ndomized pre-pubertal children with growth hormone deficiency
or short stature to one of three treatment arms: a conventional dose of growth hormone according to ...
Vitamin B12 deficiency as heart risk
...ease prevention clinics and found that vitamin B12 deficiency
was surprisingly common. They found that, in a subset of 224 patients whose creatinine levels were measured, creatinine levels appeared to be as strong a predictor of homocysteine levels as were vitamin B12 levels....
Tercica presents two pharmacokinetic studies in an oral session at Endocrine Society Meeting
...gned to study rhIGF-1 dosing inpatients with IGF-1 deficiency
(IGFD), and its effect on serum IGF-1 andIGFBP-3 levels. The first single-dose, 36-hour study observed 36 patients (12patients per group) with either severe IGFD, moderate IGFD, or who were IGF-1sufficient. The patients were randomized to receive a ...
Investigating 'brain shrinkage' in alcoholics
...habits in some alcoholics, indicates that thiamine deficiency
can contribute to impaired cognition. Cirrhosis o... these factors particularly the alcohol, thiamine deficiency
and cirrhosis are linked and probably contribute in a complex way to cause brain damage." - Both ...
Children's Hospital Oakland new sickle cell research
...at Oakland is the first to find that an amino acid deficiency
in sickle cell disease is the result of hemolysis, a process where red blood cells rupture and release their contents into the blood stream. Low availability of the amino acid arginine is associated with lung disease and death in adult sickle cell p...
American Thoracic Society Journal news tips for July 2005 (second issue)
...calcium from food and incorporate it into bone. A deficiency
of vitamin D leads to abnormal bone growth and repair. Of the 134 adults with CF in this study, 109 (81.3 percent) were found to have vitamin D levels below the recommended 30 ng/ml. Of the 49 patients who started the second eight-week repletion test...
Postmenopause and periodontal disease
...sk of alveolar bone loss and tooth loss." Estrogen deficiency
after menopause and consequent loss of bone mineral density have been shown to be associated with increased rate of tooth loss. These relationships may be explained by increased severity of periodontal disease in estrogen deficiency. The participant...
Depression linked to previously unknown dopamine regulator
...t antidepression therapies are mostly based on the deficiency
or imbalance of the serotonin and noradrenaline sy... depression is multifaceted, a hypothesis based on deficiency
or imbalance of serotonin and/or noradrenaline as the root of depression has been a central topic of...
Prenatal exposure to famine increases risk of schizophrenia
...search suggesting a link between fetal nutritional deficiency
and schizophrenia, according to a study in the Aug...ction of interest constitutes a global nutritional deficiency
or a specific micronutrient deficiency. If the former, the implications of this work are confined l...
Acrux reports progress in development of Testosterone MD-Lotion(R) for men
... Testosterone MD-Lotion treatment for testosterone deficiency
in men, which is associated with a number of symptoms including lethargy, depression and reduced libido. Both studies were conducted at the Centre for Clinical Studies, Melbourne, with Professor Susan Davis supervising as Principal Investigator. The ...
Study of new treatment for short stature underway at Rush University Medical Center
...for the most severe form of short stature due to a deficiency
of Insulin-like Growth Factor-1 (IGF-1). Ongoing trials will determine if the drug may be used for less severe growth disease. Insulin-like Growth Factor-1 (IGF-1) is the proximate hormone necessary for statural growth and must be present in order fo...
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