Pioneers in field of functional genomics work toward gene therapy for vision defects
...tem. Gene therapy has been demonstrated to correct deficits in the retina, but the major unanswered question is whether the brain can interpret new information it receives from the therapeutically-treated retina to restore vision. For humans to migrate around objects in their world requires that information a...New research shows big improvement in survival after stroke
... with an impaired level of consciousness and motor deficits following stroke. Dr Kristie Carter, Research Fellow for the study noted that, "We found that a persons level of consciousness at the time of stroke, age and history of pre-morbid dependency, were strong predictors of survival". "The increased n...Novel brain areas associated with the recognition of gender, ethnicity and the identity of faces
...culties with face recognition were due to cortical deficits near the fusiform gyrus. These data suggest that other brain regions may be involved. The fact that the cingulate gyrus is involved has some interesting implications for conditions like autism spectrum disorders." The authors are now examining how...Heavy, chronic drinking can cause significant hippocampal tissue loss
...xplain some of the memory impairment and cognitive deficits described in chronic alcoholics," added Wand. "It is unclear if the effect is reversible. It has been shown that stress-induced effects on hippocampal volume are reversible." Wand suggested future studies use a larger sample of subjects, and also ...Study by Children's Hospital and Carnegie Mellon explains crucial deficit in children with autism
... "People have not really studied these conceptual deficits in very young children as the possible basis for the social and cognitive deficits in older children and adults with autism," said Carnegie Mellon psychologist David Rakison, who co-a...Tipsheet: Focus on gait training, pain relief, pressure ulcers and hearing aid training
...ive improvements, THA patients continue to exhibit deficits in strength, postural stability, and gait. Average...mpared with community-dwelling older adults. These deficits indicate that rehabilitation is not restoring THA patients to a level similar to their peers. Clinic...New technology to speed up research into Huntington's disease
... to date in trialling new treatments for cognitive deficits has been slow with contract research organisations...ase or prion disease, and particularly where motor deficits make cognitive testing difficult or impractical.Dr Morton said "we are pleased at just how effective...Study identifies possible mechanism for brain damage in Huntington's disease
...nes, further linking decreased protein levels with deficits in energy metabolism. Additional experiments ind...rovides specific, mechanistic evidence that energy deficits contribute to neuro-degeneration in HD and suggests that enhancing energy production in the brain ma...Decision-making impairment appears greater in alcoholics with coexisting personality disorders
...t. Furthermore, identification of decision-making deficits in some patients may help to develop treatment int...pecifically designed to mediate the neurocognitive deficits underlying poor decision-making."...Can a vitamin alleviate chronic, progressive multiple sclerosis?
...f neurologic disability, and the severity of their deficits was reduced for at least eight weeks after treatme...significant. Mice with the greatest neurologic deficits had the lowest levels of NAD in their spinal cord, and those with the mildest deficits had the highe...Concussion in athletes: Can they accurately evaluate their own condition?
...ymptom free may continue to exhibit neurocognitive deficits that they are either unaware of or are failing to report."...Doctors warn: Do not rely only on what young athletes say when managing concussions
...ymptom free may continue to exhibit neurocognitive deficits that they are either unaware of or are failing to ...ll ringers,' need to be taken very seriously since deficits on ImPACT can be seen several days or even weeks post-injury," said Dr. Lovell. "These and other UPM...JRRD tipsheet: Focus on stroke
...the hospital. In addition, specific neurocognitive deficits seemed to be related to swallowing outcomes; howev...ient dominant manipulator, indicated by persistent deficits in chronic stroke patients. Because ipsilesional deficits are usually mild compared with contralesio...Preoperative brain mapping alters tumor surgery
...erwise would have been achieved. No neurological deficits were documented in any patients after undergoing surgical tumor removal. After completing this study, Dr. Petrella believes that patients who may have previously been deemed ineligible for surgery based on tumor location may be able to undergo surg...A novel mechanism of manganese-induced neurological dysfunction discovered
...pamine release, manganese exposure produced subtle deficits in behavior and fine motor function. "More work is needed to understand the relationship between the changes in behavior and the alterations in the dopamine system," explained Jay S. Schneider, professor of pathology, anatomy and cell biology at Th...Long-term abstinence may resolve many of the neurocognitive deficits associated with alcoholism
...author for the study. "The continuing presence of deficits is not a trivial issue as it may interfere with ...nnot definitively say that these individuals had deficits when they stopped drinking. We don't have data on this. Furthermore, these people were middle-aged...Survivors of childhood polio do well decades later as they age
...aking them more likely to develop symptoms. So, as deficits at the end of the disease increase, the probability of experiencing post-polio symptoms increases." The discrepancy between what some of the patients experienced with growing weakness and their actual measurements of strength and neuronal loss lik...Childhood sleep apnea linked to brain damage, lower IQ
...to link the changes in the two brain structures to deficits in neuropsychological performance. The hippocampus, a structure in the temporal lobe, is vital to learning and memory storage, while the right frontal cortex governs higher-level thinking, such as accessing old memories and using them in new situat...Pigments in corn, squash and other vegetables may help protect against age-related vision loss
... and the study may not have measured other dietary deficits that influence risk, the authors write. "This exploratory observation is consistent with a broad body of evidence from observational and experimental studies that suggests that these carotenoids may protect against AMD," they conclude. "Still, giv...Mice learn tasks that may help treat human psychiatric disorders
...does not match up with subtleties of the cognitive deficits in human mental dysfunction or with the tools we use to study the mechanisms that underlie disorders in people." Garner and his colleagues designed a task to measure a process called set shifting in which a focus on one object must be abandoned in ...