Tag: "dendritic" at medical news
Syphilis screening, lithium fights neurodegeneration, monoclonal antibodies against avian flu
...apy improves neurological function and hippocampal dendritic
arborization in a spinocerebellar ataxia type 1 mouse model. PLoS Med 4(5): e182. IN YOUR ARTICLE, PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/"request=get-document&doi=10.13...
Mice with a migraine show signs of brain damage
...th neurons shedding important connections known as dendritic
spines the tiny extensions of an individual neurons body that usually number in the thousands within a synapse. Mice in the grasp of a migraine lost up to three-quarters of these important cellular components. Ironically, the team found that durin...
Head and neck cancer vaccine targets proteins to create immune response
...d-type," p53 peptides in tumors. When presented on dendritic
cells, these wild-type p53 peptides may induce an immune response to strengthen the body's natural defenses against cancer and decrease the chance of cancer recurrence and the formation of secondary tumors. "The key to our strategy is to select th...
Study suggests use of stem cell transplantation is beneficial treatment of type 1 diabetes
...approaches under consideration include infusion of dendritic
cells, T-regulatory lymphocytes, umbilical cord cells, embryonic or adult stem cells, and allogenic bone marrow transplantation in addition to further studies with autologous hematopoietic stem cell transplantation. Research in this field is likely t...
Why doesn't the immune system attack the small intestine?
...tered from the outside environment, cells known as dendritic
cells display the antigens of their normal neighbo...rvard Medical School. "But it has been unclear how dendritic
cells, which are extremely sensitive to microbial agents such as bacteria, teach T cells to resist a...
Study offers window into human behavior, brain disease
...ar-shaped and tapered at each end, with only a few dendritic
processes extending away from them were localized in only two regions of the frontal lobes. The cells received only limited attention in the ensuing years, but in the meantime scientists determined that the brain regions in which von Economo neuron...
Structure essential for brain remodeling identified
...tructures in brain nerve cells, or neurons, called dendritic
spines. These are tiny bumps that form on the surf... receive chemical signals from other neurons. Each dendritic
spine "talks" with its counterpart on a nearby neuron, and collectively the two structures comprise ...
M. D. Anderson, BCM, launch research effort targeting asthma and allergic diseases
.... Project two focuses on how TSLP then activates dendritic
cells, key players in the immune system that engul...three, led by Liu, examines how the TSLP-generated dendritic
cells in turn propagate Th2 effector and memory cells. Project 4, led by Chen Dong, Ph.D., associa...
Combined therapies may boost immune response and long-term protection against brain tumors
...lected, cultured and introduced in a Petri dish to dendritic
cells taken from the patient's blood. The "new" dendritic
cells are then injected into the patient's bloodstream. When they encounter lingering tumor cells, t...
T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
...utic vaccine loaded with a patient's own souped up dendritic
cells, which have been galvanized to rally other c...at is key to the approach's success modifying the dendritic
cells in such a way that they will get the attention of killer T cells. Results of these studies wil...
New hope in cancer vaccines emerges as novel therapies are developed and tested
...f this approach. It involves isolating a patient's dendritic
cells (immune cells that first detect microbes and..., investigators take a blood sample to isolate the dendritic
cells, which are then grown in the laboratory and exposed to the patient's melanoma antigen, says Wi...
Baylor Institute for Immunology research receives $3 million grant to create cancer vaccines
...clinical trial in which BIIR researchers will test dendritic
cells that have been activated against melanoma pe... melanoma cancer cells). Patients will receive the dendritic
cell vaccine in combination with cyclophosphamide (CPA), an anticancer drug known to boost immune sy...
Montreal researchers identify defects of immune cells
...d that a diminution and functional defects of both dendritic
cells and CD4+ cells cause susceptibility to candidiasis in these transgenic mice by preventing T lymphocyte mediated acquired immunity to Candida albicans. The results also showed extensive perturbations in the production of cytokines required for p...
M. D. Anderson: Setting the benchmark in brain tumor treatment
... of the protein and a stimulator for the patient's dendritic
cells that activate the immune system. The research team examined the first 23 patients enrolled in the 44-patient trial, and found that it took the tumors significantly longer than is typical to come back. When the recurring tumors were rem...
Study finds novel vaccine curbs brain tumor growth, increases survival
...GFRvIII and compounds that stimulate immune system dendritic
cells, which then activate the immune system in general and cytotoxic CD8 cells in particular. "It tricks the body into thinking that EGFRvIII is foreign, and the CD8 cells are sent in to kill the tumor," Heimberger says. After initial therapy - thr...
Chemical guidance of T cells leads to immunologic memory and long-term immunity
...he surface of another immune system cell, called a dendritic
cell. Usually a third type of cell, known as a "he...s well. But how do the CD8+ T cells find the right dendritic
cells presenting the specific antigen they need to see? Moreover, how do they find the particular de...
Melanoma vaccine strategy shows promise in laboratory experiments
... prepare yet another type of immune cell, called a dendritic
cell, to present the BRAFV600E peptide to killer T... to the immune system, and the expectation is that dendritic
cells presenting the BRAFV600E peptide would trigger the killer T cells even more effectively than t...
Cedars-Sinai researchers discover treatment for deadly brain tumors and infections
...igens and present them to the immune system. These dendritic
cells, also referred to as antigen presenting cells, which normally are absent from a healthy brain, can destroy tumors as well as combat any other type of brain infections. "Our previous work in the lab has shown that Flt3 Ligand could be used to er...
Protein sorting in pigment cells sheds light on melanoma, Alzheimer's disease
... the cell, the exosomes themselves get targeted to dendritic
cells. Then exosomes ferry Pmel17 and other melanoma antigens from the melanoma tumor cell to the dendritic
cell. "Exosomes are a very hot topic now in cancer immunotherapy because dendritic
cells are good a...
How can we protect patients with weakened immune systems from influenza?
...mental treatment--an anti-cancer vaccine made from dendritic
cells. Carl June, M.D., director of translational research at Penn's Abramson Cancer Center, leads both projects. A third group of adult patients suffers from autoimmune diseases, those in which an abnormal immune system turns on itself: systemic lu...