Study in Science holds promise for a new approach to drug therapy
...n the April 21 edition of the journal Science. The discovery has the potential to improve treatments for diseas...ompound in further experiments. In a standard drug discovery technique, researchers collected several compounds (21 in this case) similar to their lead compound ...BIDMC's Harold Dvorak, MD, honored by National Foundation for Cancer Research
...of the prize committee. "Dr. Dvorak's key VPF/VEGF discovery paved the way for researchers to better understand...hoenix, Arizona, "Without Dr. Dvorak's fundamental discovery we would probably not have had the therapeutic agent bevacizumab, which has had a tremendous impact ...Latest issue of Alzheimer's & Dementia explores new ideas for cause, screening and risk factors
...s into research studies, possibly accelerating the discovery of new treatments and preventive approaches. Yet, even within the group of authors there is disagreement on the issue. The majority of the article's authors "support the consideration of dementia risk factors in individuals at age 50, with routine ye...Studies evaluate health effects of dental amalgam in children
...th, which is inhaled and absorbed by the body. The discovery raised concerns about the possible toxicity of chronic low-level exposure to mercury from dental amalgam. The toxicity of mercury at higher levels, such as from industrial exposures, is well established. Possible symptoms of mercury poisoning inclu...Mammography screenings for breast cancer show racial and ethnic disparities
... Increased use of mammography screening may enable discovery of tumors before they have progressed to an advanced stage and result in decreased mortality rates." Co-authors of the study are Diana L. Miglioretti, PhD, Group Health Cooperative, Seattle, WA; Nicole Lurie, MD, MSPH, RAND Corporation, Arlington, VA...Researchers discover new disease-causing bacterium in patients with rare immune disorder
...ng fungal and bacterial infections. Details of the discovery are described in the April 14 issue of PLoS Pathog... CGD, and possibly other individuals as well. "The discovery of new bacteria is not uncommon, but discovering an organism that causes human illness is certainly ...A virtual healthcare assistant for a healthier lifestyle
...ation technologies in the healthcare sector to the discovery of penicillin. "The discovery of penicillin allowed many diseases to be cured, the increased healthcare awareness and monitoring p...Landmark book commemorates centennial of discovery of Alzheimer's disease
... commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD)...al perspective, by recounting the tale of how each discovery unfolded and by frankly describing the contradictions among studies and the debates that once took p...Scientists learn more about how viruses reproduce, spread
...iversity School of Medicine have made a surprising discovery about the inner workings of a powerful virus a discovery that they hope could one day lead to better vaccines or anti-virus medications. Reporting in the Ap...Landmark discovery of a Kaposi's sarcoma-associated herpesvirus receptor
...o gain entry into cells of the immune system. This discovery quickly led to the identification by Dr. Berger's ... make cells permissive for KSHV fusion. The NIAID discovery may lead to new avenues for treating KSHV, says Dr. Berger. Moreover, their finding should enable sc...Researchers identify potential targets for new pain therapies
...e been in contact with various companies with drug discovery programs in place," he says. "We're interested in pursuing the idea that inhibitors of the ERK pathway or any compounds that would up-regulate the activity of these potassium channels might be effective treatments for pain." If such drugs are shown t...Novel and pioneering research offers hope for cardiovascular disease
...alia's top medical researchers. Levon Khachigian's discovery that within minutes of an angioplasty, key transcr...eive an honorarium of $50,000 to acknowledge their discovery and contribution to science and help further their work. The Award is regarded as one of the most pr...New 'wrinkle' in Botox treatment could lead to lower doses, better safety
...d increases its normal function," Janda says. "The discovery of small molecule activators may ultimately provide a valuable method for minimizing dosage, reducing resistance, and increasing its clinical efficacy." One possible complication of Botox injections is that their repeated use can lead to recognition...JCI Table of Contents, April 3, 2006
... will be a critical area for future research. This discovery suggests a distinct pathway for activation of the RAS that may have a particular impact in the pathogenesis of chronic tissue injury as well as more acute pathology such as arrhythmias in the heart." He summarizes by stating that, "the finding that m...Jefferson scientists reveal new mechanism that causes spread of colorectal cancer
...s initiate the process, known as metastasis. Their discovery of a new molecular mechanism by which MMP-9 promotes cancer spread may provide a new target at which to aim anti-metastasis drugs. MMP-9--matrix metalloproteinase 9--is a member of a family of enzymes that is instrumental in freeing cells from surrou...Federal law should require ID of stores that sold recalled food, study suggests
...after that. However, the cases varied widely, with discovery of the problem ranging between 1 and 480 days and the duration of a recall ranging from 6 to 616 days. "These time periods are much too long, considering that some of these products have a shelf life of only about nine days," Hooker said. "This says...Cedars-Sinai researchers discover treatment for deadly brain tumors and infections
...cit a very potent anti-glioma immune response. The discovery on the mechanisms to overcome the immune privilege in the brain will open up very exciting therapeutic opportunities to treat primary and metastatic brain cancers and deadly brain infections. The high levels of Flt3 Ligand molecules recruited an elev...Pregnancy research leads to progress on premature delivery
...premature delivery of low-birth-weight babies. The discovery is an incremental step in an area of obstetrics that has seen little improvement in 20 years. Mark Plessinger, Ph.D., assistant professor of Obstetrics and Gynecology at the University of Rochester Medical Center, discovered that certain proteins kno...Protein sorting in pigment cells sheds light on melanoma, Alzheimer's disease
...is process also happens in non-pigment cells. This discovery indicates that sorting is not a melanocyte-specific process; the sorting phenomenon is a general one. Other researchers have found that the Alzheimer's precursor protein, the prion protein (responsible for Creuztfeldt-Jakob's Disease, Mad Cow diseas...'Executive' monkeys influenced by other executives, not subordinates
...iduously follow the gaze of all other monkeys. The discovery represents more than a confirmation of what most p... involves lightning-fast social perception. Such a discovery in monkeys gives the researchers an invaluable animal model that enables them to tease apart the ref...