Scientists stop colon cancer growth in mice by blocking just one enzyme
... K. Srivastava, senior author of a paper about the discovery to be published Oct. 1 in the journal Cancer Research. According to the federal Centers for Disease Control and Prevention, colon cancer is the country's second leading cancer killer. In 2002, the most recent year for which statistics are available...ABCB6 is key to production of heme in hemoglobin
...use oxygen to produce energy-rich molecules. The discovery of the location and function of ABCB6 solved the long-standing riddle of how porphyrins get into mitchondria so they can be used to make heme, said John Schuetz, PhD, a member of St. Jude Pharmaceutical Sciences. "Porphyrins are negatively charged an...Major cancer study aims to identify protein markers for early-stage disease
...y detection of cancer, are designed to lead to the discovery of many such biomarkers, the scientists say. The grants have been issued under the NCI's Clinical Proteomic Technology Assessment for Cancer program, part of its five-year Clinical Proteomic Technologies Initiative for Cancer. The team is directed b...Feinstein Institute's top scientist weighs in on mind-body medicine at conference with Dalai Lama
...ture in December 2002, Dr. Tracey's groundbreaking discovery that the brain controls the immune system via the vagus nerve -- the largest nerve in the body that wanders through the major organs -- has gained international acclaim, including a Nobel Conference dedicated to the topic hosted by the renowned Karol...Emotional control circuit of brain's fear response discovered
...us responses may be more automatic. Following the discovery of the amygdalas role in fear response, we decided to explore the finer points of the neurocircuitry of fear how it is regulated and controlled in the brain, said Dr. Hirsch.facial expressions. To study emotional regulation, Dr. Etkin collaborated w...Wiley to assume publication of Mount Sinai Journal of Medicine
...at, focus and publisher the gap between scientific discovery and clinical application for physicians, investigators and translational researchers." Wiley will publish Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine in print and online via Wiley InterScience ( www.intersci...UCSD researchers create roadmap to integrin activation
...published a paper in the journal Science about the discovery that talin a large cytoplasmic protein that binds to the inside of an integrin or family of integrins delivers the critical activation signal. Talin is very important in the linkage between a cell's cytoskeleton and integrins, linkages that cell...Two-faced protein can stop metastasis or promote it, researchers say
... because the findings open up a whole new field of discovery for novel therapeutics that should be applicable to most types of tumors." Their laboratory study looks at how p120 catenin interacts with different cadherin cell adhesion proteins in cancer cells. Cadherin proteins go through a cell membrane, and o...Road wends its way through stomach
... long time, even hours in the real stomach. "This discovery might explain observed high variability in drug initiation time, and may have important implications to both drug delivery and digestion," the researchers report online in the Journal of Biomechanics. The paper will appear in a print edition in 2007....New drug target might sidestep gleevec resistance, Jefferson scientists show
...cule that can activate the C/EBP-alpha gene. The discovery could also have applications for other leukemias, he notes, because there are several different mechanisms by which C/EBP-alpha is inactivated. Other scientists have shown that in various types of leukemia, reintroducing C/EBP-alpha can restart diffe...Tulane researcher reports on origin of deadly fever outbreak
...es was a factor in the spread of the disease. The discovery of multiple different genetic variants of the virus indicates that the two-year outbreak was fueled by repeated new introductions of the virus into humans from the primary reservoir, rather than simply a single introduction followed by person-to-pers...An advanced genetic diagnostic method for multiple myeloma
...tients with MM. This methodology has permitted the discovery of associations between specific chromosomal changes, and thus the description of a new classification of the disease. In addition, the technique of hybridization in situ with fluorescence allowed him to identify new recurrent genetic changes that ar...IOS Press presents commemorative volume on Alzheimer's Disease to her majesty, Queen Sofia of Spain
...k commemorates the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's Disease (AD). Each conference participant received a copy of the book with the compliments of GlaxoSmithKline. Khalid Iqbal, one of the conveners of the conference, makes the presentation to Queen Sofia. Left t...Claiming diagnostic tests for diabetes genes is misleading, say experts
Claims that the discovery of a gene could help prevent diabetes may raise un...le habits that lead to diabetes. Undeniably this discovery is noteworthy, write Cecile Janssens and colleagues. Type 2 diabetes is a leading cause of illness a...Carnegie Mellon receives NIMH/NSF grant to examine mechanisms that underlie neuronal synchronization
... added. Urban's NIMH/NSF funding arises from his discovery of stochastic synchrony, a novel mechanism for generating synchronous neuronal firing. With this latest award, he will further investigate the cellular- and circuit-level properties that orchestrate this coordinated neuronal activity. "Using a comb...BC catalyst discovery promises faster, cheaper drug production
...the waste generated in laboratory syntheses." The discovery is based on the concept of chirality, which refers... the process at the same time. "What makes this discovery enormously significant is that silyation is already one of the most useful ways if not the most eff...Nobel Laureate keynote speaker at conference on nanomedicine, geriatric care, brain injury
...Robert F. Curl and Richard E. Smalley for the 1985 discovery of fullerenes (C60 Buckminsterfullerene), a new form of carbon in which the atoms are arranged in closed shells. Kroto's research areas in addition to fullerenes are spectroscopy of unstable species and reaction intermediates, cluster science, includ...Licensing arrangement reached for antiepileptic drug
...ersity School of Pharmacy. Bialer, a leader in the discovery of antiepileptic agents, has authored over 180 publications in the area of pharmacokinetics, antiepileptics and central nervous system (CNS) drugs. Epilepsy is a widespread neurological disease. Approximately one percent of the world's population...Study uncovers mechanism of drug resistance in form of lung cancer
...es, but by the more advanced HPLC technique. The discovery offers hope to some NSCLC patients who have relapsed after taking Iressa or Tarceva, remarks Jnne, who is also an assistant professor of medicine at Harvard Medical School. "Drugs capable of blocking the activity of mutated T790M may be effective t...Key study offers hope to patients with lung and joint disease
..., joints and other organs could benefit from a new discovery by scientists at the University of Edinburgh. A new study in Nature Medicine journal shows that certain drugs, already being tested as cancer treatments, can dramatically reduce tissue inflammation. The researchers have found that certain non-biolog...