Study finds radiation therapy for prostate cancer nearly doubles risk for rectal cancer
..., some portions of the rectum still receive a high dose of radiation. Therefore, the risk of rectal cancer may still exist and thus, until proven otherwise, men treated with radiation for prostate cancer need monitoring for rectal cancer beginning five years after treatment. This research study was funded...Radiation therapy for prostate cancer nearly doubles the risk of rectal cancer
... portions of the rectum might still receive a high dose of radiation. Therefore, the risk of rectal cancer may still be substantial and thus, until proven otherwise, men treated with radiation for prostate cancer need monitoring for rectal cancer beginning five years after treatment. Guidelines of multip...Statin simvastatin linked to protection against endothelial dysfunction in diabetic rats
... medication, found that diabetics who took a daily dose of the statin drug simvastatin over five years reduced the risk of a first nonlethal heart attack by 37 percent and risk of a first nonfatal or fatal stroke by 24 percent, regardless of their cholesterol or glucose levels. That is significant, since...Once-a-month injectable medication helps treat alcohol dependence
Because of problems with adherence to a daily oral dose of naltrexone, the effectiveness found in treating alcohol dependence with a once-a-month injection of naltrexone could improve long-term treatment outcomes, according to a study in the April 6 issue of JAMA. Alcohol dependence is a major public heal...Less cognitive impairment seen in women taking drug for osteoporosis
...steoporosis were randomly assigned to take a daily dose of either 120 milligrams of raloxifene, 60 milligr...ed for dementia. In those women, the 120 milligram dose conferred a 33 percent lower risk of developing mild cognitive impairment when compared with the 60 ...Nutritional supplement reduces need for traditional ulcerative colitis treatment
...t vs. a placebo had a significant reduction in the dose of corticosteroids needed to control clinical symptoms of ulcerative colitis. Ulcerative colitis is an inflammatory bowel disease in which the lining of the large intestine becomes inflamed and ulcerated, and most commonly affects people between 15...Study reveals drinking alcohol reduces breast milk supply in women
...onses were measured after they consumed a moderate dose of alcohol (0.4 g/kg). The results showed a significant decrease in oxytocin level, which correlates with the decline of milk ejection and production, dismissing the lore that alcohol is a galactagogue. Furthermore, the increased prolactin levels ar...Data show cyclosporine inhalation solution improves long-term survival in lung-transplant patients
...immunosuppression, and underwent an initial 10-day dose escalation phase to reach a maximum tolerated dose...lowing initiation, patients received a maintenance dose of either the CyIS or placebo three times per week for two years. Upon completion of dosing, all sub...Deep brain stimulation in Parkinson disease reduces uncontrolled movements
...d in either group. Levodopa [Parkinson medication] dose was reduced by 38 percent in STN stimulation patients compared with three percent in GPi stimulation patients. Dyskinesia was reduced by stimulation at both GPi and STN ( 89 v 62 percent). Cognitive and behavioral complications were observed only in...Bad outcomes related to, but not caused by, misdosing of clotbusters in heart attack patients
... receiving an underdose. Those receiving a correct dose had a mortality rate of 5.4 percent. Conversely, t...rate for underdose. Those who received the correct dose of placebo also had a 5.4 percent mortality rate. "These findings are counterintuitive when given t...Adverse outcomes from blood clot therapy may be due to patient characteristics, not dosing errors
...ers were able to hypothesize that if the incorrect dose was causing adverse outcomes, the association betw...teplase compared with those who received a correct dose (5.4 percent). The surprising finding was that the same pattern was observed in patients who receive...Tamoxifen can reduce breast pain in prostate cancer patients
...50 patients to 150 mg bicalutamide per day and one dose of radiotherapy at the start of treatment. Patie...amoxifen, and 15 of the 50 receiving an additional dose of radiotherapy. 35 patients assigned to bicalutamide only subsequently developed breast enlargement...Sex, age and sun exposure linked to frequency of sunburns
...years. "In conclusion, persons had the highest UVR dose on sunburn days with risk behavior. Adolescents and younger adults had the most sunburn days, the most risk-behavior days, and the most exposure hours between noon and 3 P.M. and thus accumulated the highest UVR dose," the researchers state. "Campaig...Patients' lives at risk from substandard drugs say heart specialists
...n composition and purity. Said Dr Hermentin: "The dose of fibrinolytic agents such as streptokinase must ...activity while avoiding adverse effects. Too low a dose won't restore blood flow in the artery and too high a dose could cause a bleed in the brain. "While ...No strong evidence linking mercury levels with worse neurobehavioral performance in older adults
...ncern for older adults. Studies with more detailed dose assessment are necessary to confirm this conclusion since a single blood-mercury level may not be an optimal estimate of cumulative dose," the researchers conclude....Heart failure drug associated with higher risk of death
...rom the two clinical trials that used the starting dose of nesiritide that is now recommended to physicians. Aaronson hopes the new finding will give physicians better perspective on the risks of nesiritide, which is perceived as being more effective and safer than dobutamine, an inotropic (heart strength...Increasing benefit seen in novel drug that treats Gleevec resistance
...tifiable when all patients are on the maximal safe dose - a dose which we have not yet defined." Clear activity was seen at the very first dose of 50 milligrams offe...Researchers determine two arthritis medications are safe and effective for children
...ic arthritis." The study also showed that a higher dose of methotrexate than previously thought can be used safely in children and that at the increased dose there was increased efficacy. Establishing drug dosages in children is more complicated than adults ...Anti-malaria drug combination could help address treatment crisis in Africa
...od intake and in patients who only had their first dose supervised and were given nutritional advice. The trial involved around 960 patients, of all ages, with uncomplicated falciparum malaria in Mbarara, Uganda. Dr Piola concludes: "We believe that the six-dose regimen of artemether-lumefantrine is a ve......ility to focus more drug at the tumor site, so the dose at the site might be ten to a thousand times higher than if you had administered the drug systemically," Lanza says. The nanoparticles also may permit more effective follow up, because a doctor could use them to discern whether a tumor was still grow...