Tag: "dosing" at medical news
AACR establishes new lectureship in honor of Dr. Jane C. Wright
...erapeutic drugs in humans which produced effective dosing
levels and helped saved lives. Dr. Wright began her pioneering work in 1949, and during her forty-year career she published over 100 research papers on cancer chemotherapy and led delegations of cancer researchers to Africa, China, Eastern Europe, a...
Study shows light therapy to effectively treat mood disorders, including SAD
...e age spectrum, the requirements for light therapy dosing
might differ. Also, children and adolescents may need lower doses than the elderly. "And if eye problems such as cataracts are more prevalent among the elderly, might light therapy aggravate the problem, even slightly?", Golden added. As to efficacy...
Bad outcomes related to, but not caused by, misdosing of clotbusters in heart attack patients
...y worried about the possibility of minor errors in dosing
-- a concern that the Duke physicians said likely ...Many physicians have assumed that modest errors in dosing
errors of these fibrinolytic drugs can cause harm, which made them afraid to give the drugs altogeth...
Adverse outcomes from blood clot therapy may be due to patient characteristics, not dosing errors
Even though incorrect dosing
occurs in about 5 percent of patients with heart a...r to be more responsible for adverse outcomes, not dosing
errors, according to a study in the April 13 issue of JAMA. Several studies have reported higher dea...
UT Southwestern researchers show new drug may help treat certain forms of leukemia
...tively long half-life in mice indicates once-daily dosing
might be possible in humans. PD166326 is in a different class of anti-leukemia drugs currently being investigated by other researchers for their effectiveness in Gleevec-resistant patients. Dr. Ilaria's lab is continuing research in Gleevec resistanc...
Mayo Clinic researchers use pharmacogenetic test prior to chemotherapy to reduce toxic side effects
...l, thus reducing toxicity. This kind of customized dosing
approach based on a person's genetic makeup is known as "pharmacogenomics" and is the newest frontier of 21st century medicine. "In the past, a physician knew that the genetic test could predict a higher risk for irinotecan-related toxicity," says Dr...
New method of administering anti-cancer drug may be more effective, safer
...e us a new opportunity for consistent and targeted dosing
for individual patients," Shea said. Shea and his...colleagues are developing a study of such tailored dosing
and hope to open a clinical trial by the end of the summer....
Small, open-label study shows potential use of novel antibiotic rifaximin for Crohn's disease
...inflammatory bowel disease, as well as the optimal dosing
schedule, should be explored in well-controlled, double-blinded clinical studies. Crohn's Disease is a chronic inflammatory disease of the intestines and is frequently referred to as inflammatory bowel disease (IBD). It primarily causes ulcerations ...
Personalized immunosuppression with leading organ transplant therapy may optimize patient care
...and patient and organ survival was similar in both dosing
groups. In addition, the personalized dose (TDM) ... OptiCept TM study will compare traditional fixed dosing
of CellCept with personalized dose adjustment based on measurement of CellCept blood concentrations....
Penn study points to how COX-2 inhibitors can eventually lead to heart disease
... of increased cardiovascular risk during continued dosing
with either Celebrex or Vioxx," says FitzGerald. "...tors. These findings suggest that during prolonged dosing
with COX-2 inhibitors, several consequences of drug actiona rise in blood pressure, initiation, and ...
Pfizer's antifungal VFEND provides significant cost advantages when used as initial therapy
...ated to the efficacy, tolerability and IV and oral dosing
flexibility of VFEND. These savings are especially apparent when VFEND is used as initial therapy for these infections," said James Lewis, Pharm. D., lead investigator and infectious diseases pharmacy specialist at The University of Texas Health Sci...
Diabetes knowledge has little effect on improving outcomes
...re to begin appropriate medications and inadequate dosing
are all well-documented shortcomings of our health care system," Sanchez said. He pointed out, for example, that on enrollment to the study, only two-thirds of the patients were taking medications that have been proven in clinical trials to improve t...
Tercica presents pharmacokinetic and safety data from several studies at Endocrine Society Meeting
...3 (IGFBP-3). The model can be used toguide rhIGF-1 dosing
in order to better normalize a child's blood IGF-1 level. A second study described a new test, the IGF-1 Production Test, which usesdata generated from the POP-PK model to estimate the amount of IGF-1produced by a child before and after growth hormon...
Study shows new method of growth hormone dosing improves height
A randomized UCLA study found that a new dosing
paradigm can improve height outcomes in the treatm...ion based upon weight. The authors described a new dosing
approach based on the serum levels of insulin-like growth factor-I (IGF-I), the growth hormone GH-de...
Tercica presents two pharmacokinetic studies in an oral session at Endocrine Society Meeting
...We designed these studies to determine the rhIGF-1 dosing
necessary tonormalize IGF-1 levels in IGFD childre...n thebloodstream, which may help guide the optimal dosing
of rhIGF-1 to achievephysiologic IGF-1 replacement, and in turn, optimal growth." The pharmacoki...
Fine tuning drug levels in neuroblastoma patients is effective, St. Jude researchers show
...e long-term survival," Stewart said. "But PK-based dosing
appears to be a way to improve those odds by letti...r tumor size if treated according to the PK-guided dosing
strategy," said Victor Santana, M.D., director of the Solid Tumor division and co-leader of the Soli...
ARRS president responds to NAS report on ionizing radiation
...committed to ALARA [as low as reasonably possible] dosing
as a guiding principle for administering X-rays for necessary tests. Patients should consult with their doctors and seek board certified radiologists for the performance and interpretation of examinations that require X-rays," he said....
The Cochrane Library newsletter, 2005, issue 3
...frequently have no menstrual bleeding, the monthly dosing
with combined contraceptives causes levels of horm...us continuously. Their conclusion was that the two dosing
regimens have similar participant satisfaction and similar discontinuation rates. They also found ev...
Newest HIV drugs should be used with FUZEON(R)
...tients not receiving FUZEON POWER Phase II TMC114 dosing
trials Over 24 weeks in the combined TMC114 trials, almost double the proportion of patients who received FUZEON plus TMC114/r achieved a viral load below 50 copies/ml compared with patients not receiving FUZEONA remarkable 67% of the patients recei...
Promote use of drugs to prevent AIDS infection, researchers urge
...ote. "Clinical trials of daily oral antiretroviral dosing
as pre-exposure prophylaxis, or 'PrEP,' have been initiated in Africa, Asia and the United States and are planned in Latin America. Unfortunately, these trials have become controversial." Authors of the commentary include Dr. Robert M. Grant, associa...
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