Adult stem cells aid recovery in animal model of cerebral palsy
...e bone marrow of rats and expanded by Athersys for dosing in the injury model, Dr. Carroll says. Seven days after injury, stem cells were injected directly into the brains of 22 animal models through a tiny hole in the skull. As with human transplant recipients, the animals were placed on immunosuppressiv...Novartis MS drug shows promising results
...witched from placebo to either the 1.25 mg or 5 mg dosing of FTY720 after six months, the annualized relapse rate was reduced by at least 70% during the second six-month study phase compared to the first six months on placebo. More than 80% of patients who received FTY720 for up to 12 months were free from...American Thoracic Society journal news tips for October 2005 (first issue)
...s look at symptoms to guide inhaled corticosteroid dosing in asthma. However, symptoms are nonspecific and not closely related to the presence and severity of airway inflammation. They note that symptom-based treatment could lead to excessive inhaled corticosteroid doses, while fear of side effects could ...Annals of Internal Medicine tip sheet for Oct. 18, 2005
...e, used before each meal, is large and only allows dosing of 2.5 to 3.0 units of insulin, while injected insulin currently allows for finer adjustments in dose. An editorial writer says that the two new treatments provide much-needed options for treating the later stages of diabetes (Editorial, p. 609). Ho...Chemotherapy errors rare, but have potential for serious consequences
...rated, a few classes are toxic and require complex dosing regimens, such as those used in chemotherapy. Even a low error rate from these medications could potentially lead to significant harm, including death. Aside from a few case reports in journals and popular media, little research has investigated the...Focus on lung cancer: How to prevent and treat it
...ne vaccine, as well as the best dosage and optimal dosing schedules. A multi-site clinical trial randomly assigned 68 smokers to receive different doses of vaccine, or placebo, and followed them over 38 weeks. The vaccine was well tolerated among the subjects. Aches and tenderness at injection sites were ...Cannabis-based medicine relieves the pain of rheumatoid arthritis and suppresses the disease
...idual response over a period of two weeks. Stable dosing was then maintained for a further three weeks." Th...ials are run, researchers will probably extend the dosing period over the full 24-hour period. Dr Robson said: "The beneficial effects in this study occurred...Data on herceptin for early breast cancer currently insufficient for decision on its use
...ncet also notes that the two reports use different dosing regimens, making comparisons and conclusions difficult. Comparisons are further hampered by the omission of crucial overall and disease-free survival data, as well as information on cardiotoxicity. However, it is clear that Herceptin can precipitate ...Amgen investigational therapy for bone loss, denosumab, show increased bone mineral density
...ent for Fosamax 70mg weekly. Across all doses and dosing intervals, denosumab increased the BMD of the lumb...he same time period. Denosumab, at all doses and dosing intervals studied, increased total hip BMD from 2.8 to 5.1 percent. Across all doses and dosing int...Flexible drug dosing produces less side-effects in people with epilepsy
For the first time, researchers compared dosing regimens of an antiepileptic drug (AED) used for t...s, in conjunction with other AEDs. They looked at dosing used in clinical everyday life (flexible dosing) and that used in classical clinical trials (fixed d...Misdosing common for powerful anti-clotting drugs
...ve proven that these drugs can save lives, correct dosing is crucial, the researchers said, since the therap...l types of hospitals across the country shows that dosing errors occur more often in vulnerable patients, such as women, the elderly, or those with kidney ins...Abdominal chemo boosts survival in ovarian cancer patients
...currently a drug-of-choice for IP therapy. "Modern dosing techniques may reveal that may not be true, and we're conducting an early study of IP therapy with carboplatin," says Armstrong. Some investigators are also studying ways to add new agents that are highly specific for cancer cells into the IP regime...Penn researchers call for new paradigm in clinical trials
... duration of action of a drug; and the duration of dosing and concurrent therapies, such as low-dose aspirin. The authors indicate how the clinical information from placebo-controlled trials of the COX-2 inhibitors is congruent, both in outcome and in how the information became manifest, with what would be ...Older drugs may be good stopgap treatment for malaria in Africa
...ecause of low production, comparatively high cost, dosing complexity and the lack of clinical experience with artemisinin-based combinations," Bukirwa and Critchley say. The Cochrane reviewers analyzed four studies including 775 malaria patients, children age six months to five years. The studies compared t...Breast ducts: A new site for cancer treatment?
...sions, as well as different chemotherapy drugs and dosing schedules. More than 200,000 cases of breast cancer are diagnosed in the U.S. annually. DCIS accounts for 20 - 40 percent of these cases, according to researchers....Methadone therapy - one dose does not fit all
Study supports a flexible approach to methadone dosing Methadone has been used for more than 30 years as a treatment for heroin addicts. Doctors have all along struggled to find the best doses to help patients overcome their heroin cravings without getting them used to higher levels of methadone (itself...North Central Cancer Treatment Group finding ways to make treatment easier
...he two therapies. Although this reduced frequency dosing schedule would be more convenient for patients, the researchers say that clinicians will have to decide whether the potentially lower hemoglobin levels are an acceptable trade-off....Many high risk patients do not receive cholesterol-lowering therapies
...6%). The drug remained effective over the 24-hour dosing period, and demonstrated the same side effects as placebo up to the 300 mg dose. At the 600 mg dose, patients experienced a greater incidence of diarrhea, but there were no serious side effects in any of the dosage groups or the placebo group. "Alis...Accentia Biopharmaceuticals to begin shipping MD Turbo
... rescue medications during acute attacks. Improper dosing and other misuses can lead to negative outcomes, such as the exacerbation of symptoms and even hospitalization," says Gary Cantrell, TEAMM Executive Vice President of Sales and Marketing. "But with MD Turbo physicians will be able to prescribe their ......the quality of the test drug, no contamination, no dosing error, and "it was run according to the agreed pro...on in the published documents of any precautionary dosing interval between volunteers. As the Academy of Medical Sciences suggests: 'it would be usual practic...