Researchers devise safer way to dose life-saving heart drug
... Chicago have taken the dangerous guesswork out of dosing a lifesaving medication for congestive heart failu...d with improved mortality," Bauman said. "However, dosing methods have not been modified to reflect this change. In the study, we sought to develop a new meth...Study finds unexpected results in acid suppression between two OTC heartburn treatments
... show similar acid suppression on the first day of dosing between these drugs as reported today in Alimentary Pharmacology & Therapeutics. Researchers also report evidence that with daily use, the body develops a rapid onset of tolerance to even a low dose H2RAs such as Pepcid AC. The findings may help p...African scientists will train at Emory University in latest drug discovery techniques
...them for six to nine months. With such a prolonged dosing period, it is very difficult for people to remain compliant." Dr. Liotta and his collaborators are hoping to develop anti-tuberculosis drugs that will require only two-week regimens. ...UW launches study testing adult stem cells for heart damage repair
...are randomly selected to receive either one of two dosing levels of CD34+ stem cells, or placebo. Subjects will receive follow-up examinations for 12 months following the investigative procedure. "The initial results from Phase I of the trial were encouraging," Raval says. "Subjects reported feeling bette...LIALDA -- the first oral once-daily mesalamine for ulcerative colitis -- now available
...able mesalamines require three to four times daily dosing and six to 16 pills a day. A study found that pati...sion. Additionally, LIALDA's convenient once daily dosing may help address the compliance issues facing so many ulcerative colitis patients," said Mike Cola, ...EVEREST data on use of tolvaptan published in JAMA and featured at ACC
PRINCETON, N.J., March 25, 2007-- Once-daily dosing with Otsuka's investigational oral medication tolvaptan, a vasopressin receptor antagonist, was associated with improvements in signs and symptoms of acutely decompensated heart failure (ADHF) in hospitalized patients receiving conventional care, wit...New data shows once a day LAMICTAL XR is effective in patients with partial epilepsy
...reduces the frequency of seizures. The once daily dosing regimen may also provide a more convenient treatme...n (7 weeks) and maintenance phases (12 weeks) with dosing based on background AEDs. The primary endpoint was percentage change from baseline in weekly partial...Alpharma presents positive pharmacokinetic study results
...phine pharmacokinetic analysis were drawn prior to dosing and at intervals from 0.5 to 168.0 hours post-dose...oid-tolerant patients only. KADIAN offers flexible dosing and administration options that allow physicians to fine-tune titration schedules and tailor treatme...FDA approves Dey, L.P.'s Perforomist inhalation solution for maintenance treatment of COPD
...r disease symptoms. The convenience of such simple dosing combined with a drug delivery option favored by many patients may provide improved symptom control and a better quality of life for the millions of Americans who live with COPD." Mel Engle, President and CEO at DEY, noted, "As the US leader in ne...Smokeless cannabis delivery device efficient and less toxic
...es patients the same effects and allows controlled dosing but without inhalation of the toxic products in smoke," said study lead author Donald I. Abrams, MD, UCSF professor of clinical medicine. The research team looked at the effectiveness of a device that heats cannabis to a temperature between 180 and...Ulcerative colitis sufferers find UC quite disruptive to many aspects of daily life
..., 5-ASA therapies required two to four times daily dosing and up to 6 to 16 pills a day. "It's troubling t...we need to address is compliance. More convenient dosing regimens such as once-daily dosage formulations may be part of the solution." Bridging the physicia...Lowering body temperature could aid standard stroke treatment
...temperatures could allow a physician to adjust tPA dosing in a stroke patient if hypothermia is being induced as well," says Shaw. "There are multiple medications and treatments for heart attacks, but not for stroke," he adds, "because stroke therapies are still in their infancy. This study offers another...Targeted nanoparticles incorporating siRNA offer promise for cancer treatment
...ur most recent work examines the impact of various dosing schedules and surface modifications on the efficacy of these siRNA nanoparticles in preclinical cancer models. By combining the experimental data with a mathematical model of siRNA-mediated gene silencing, we illustrate several practical consideratio...The hepatitis C link: Diagnose, treat, transplant
...his study. "Further clinical research on the best dosing regimen and combinations is warranted to optimize the potential of this innovative combination for chronic HCV patients." Dr. Kaita will present this study on Monday, May 21, at 2:45 p.m. in Room 206. Use of Hepatitis C-Infected Donors in Liver ...Most pediatric chemotherapy mistakes reach patients
...t errors in drug administration and errors in drug dosing and frequency were the most common mistakes made a... drug and errors were commonly related to improper dosing (23 percent), timing or frequency (23 percent). Interestingly, compared to inpatient facilities, out...Study questions risks of anti-bleeding drug during heart surgery
...ed. If you are using celite-ACTs to guide heparin dosing in a patient treated with aprotinin, you will think you gave enough heparin when in fact you didn't." This interaction may explain some of the increased risks with aprotinin reported in previous studies. However, Dr White did not want to dismiss t...FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
...nism of action that, combined with its twice-daily dosing regimen, could fundamentally expand and improve the treatment options available to asthma patients. We are delighted to participate in commercializing Critical Therapeutics ZYFLO CR, which will continue to expand DEYs presence in asthma and respirat...'Heroes of Chemistry' honored for medical, energy, environmental breakthroughs
...ond generation) antipsychotic medicine that offers dosing flexibility, proven efficacy and a favorable side-effect profile: Unlike many other atypical antipsychotics, Geodon does not cause weight gain on long-term therapy, which is a significant advantage. Also marketed under the trademark Zeldox, Geodon is...Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
...successes of pharmacogenomics (individualized drug dosing based on hereditary factors) and discuss the remaining challenges to its widespread clinical use. Citation: Swen JJ, Huizinga TW, Gelderblom H, de Vries EGE, Assendelft WJJ, et al. (2007) Translating pharmacogenomics: Challenges on the road to the ...