New therapeutic targets for neurodegenerative diseases
...ecules of the cell that recognise a pharmaceutical drug and thus respond to it) and, in the last analysis, to come up with pharmaceutical medicines that improve treatment....... Room 2 at 08.30 Levosimendan is a first-line drug in the management of acute heart failurePro: (F. Follath); Contra: (J. Cleland) BNP is an obligatory biomarker for long-term management of chronic heart failurePro: (G. Jondeau); Contra: (J.J.V. McMurray) Room 1 at 11.00 Haemodynamic monito...Scientists equip bacteria with custom chemo-navigational system
...e opened the door to powerful new opportunities in drug delivery, environmental cleanup and synthetic biol...would open new frontiers in environmental cleanup, drug delivery and synthetic biology," says Dr. Gallivan. The researchers equipped E. coli with a "ribos...Effectiveness of first renin inhibitor drug for treating hypertension is limited
...rt that, because of reactive renin secretion, this drug has not been any more effective than those already widely available to control hypertension. Renin inhibitors, for which aliskiren is a prototype, become the fourth class of drugs to lower blood pressure by blocking the renin-angiotensin system. Pr...New relief for unexplained chest pain
...was seen in nearly 60 percent of patients, and the drug was reasonably well tolerated," adding that "if a cardiac, pulmonary, musculoskeletal or esophageal source such as acid reflux disease can be excluded, our findings suggest that a trial of theophylline may be effective in relieving chest pain." ...Comparison of patients' access to new and better cancer drugs reveals inequalities between countries
...ween 10-20% of this expenditure and just 5% of all drug costs. But cancer research continues to grow, with... Ensuring that once authorisation is obtained, the drug is available at national level without further delays due to price and reimbursement negotiations; ...NIH funding UIC brain tumor research
...er of the study. The novel approach stabilizes the drug and provides better control of the time and locati...y reducing its side effects. Gemeinhart said the drug will be activated from the hydrogel through the overactivity of matrix metalloproteases, enzymes tha...Study implicates protein as a trigger of advanced prostate cancer recurrence
...advanced prostate cancer in men who are undergoing drug treatment to shut down their sex hormones, or andr...xciting possibility that we can develop a specific drug against this," said senior study co-author Dr. Young Whang, associate professor of medicine at UNC-C...Animal study identifies promising new target for brain tumor therapy
DURHAM, N.C. -- A drug that targets the bodys immune cells may be effecti...rt Tisch Brain Tumor Center. In animal models, the drug re-engaged the bodys cancer-damaged immune system. "We were effectively targeting bad T cells that...Agent protects cells from lethal effects of radiation even if given after exposure
.... The researchers contend that developing such a drug would be less challenging than finding a way to pr... tissues," Hunt said. "This is difficult because a drug has to distinguish between tumor and normal tissue. But with people exposed to a large dose of radia...Angioplasty reduces long-term cardiac risk among heart patients with 'silent' ischemia
When compared with intensive drug therapy, percutaneous coronary intervention (PCI, ...y 25, 1997, to determine whether PCI compared with drug therapy improves long-term outcome of asymptomatic patients with silent ischemia after a heart attac...Risk of lymphoma increases with hepatitis C virus infection
...ic status, and particularly a history of injection drug use or blood transfusions received before 1990, when screening for hepatitis C virus was started. ...Warts vaccine -- 1 of many in pipeline
...ering for medical discoveries, clinical trials and drug manufacture. "Conducting trials in Australia gives Australians the chance to help develop new treatments," Professor Frazer said. "Should the product under trial be effective, it also gives them the chance to be amongst the first to benefit." ...Off-label and untested use of drug-coated stents appears widespread
...uting stents are normal metal stents coated with a drug that is known to interfere with the process of restenosis (re-obstruction). Data on the use of drug-eluting stents outside of approved indications in real-world settings are limited, according to background information in the articles. Nirat Beo...Baby aspirin better for your health, University of Kentucky study says
...r doses of aspirin. "While aspirin is an effective drug for the prevention of clots," said Campbell, lead ... from person to person." Aspirin is the most-used drug in the world. More than 50 million people, or 36 percent of the adult population in the United State...... discovery also provides new potential targets for drug development that could one day be used to treat a range of such disorders. This research was funded by the Medical Research Council, the Wellcome Trust and the European Union....Alpharma presents positive pharmacokinetic study results
...overnight fast, subjects either received the study drug (containing 60 mg morphine sulfate) or consumed a ...igh-calorie, high-fat breakfast and took the study drug 30 minutes later. Blood samples for morphine pharmacokinetic analysis were drawn prior to dosing and...Cholesterol-lowering drugs reduce risk of stroke, heart attack
...the participants received the cholesterol-lowering drug atorvastatin and half received a placebo. The participants were then followed for an average of four and a half years. For each 10-percent decrease in LDL, or low-density lipoprotein bad cholesterol, the risk of stroke was reduced by four percent...Once-yearly treatment significantly reduces bone fractures in women with postmenopausal osteoporosis
...menopausal osteoporosis. The FDA has approved the drug for the treatment of Pagets disease of bone, the second most common metabolic bone disorder after osteoporosis.......l fracture types." Reclast is an investigational drug in the bisphosphonate drug category that is being developed by Novartis Pharmaceuticals Corp., a U.S. affiliate of the Swiss-ba...