Forensic pathologists tell physiologists what they know about death and what puzzles them
...fants sleep in their cribs, and following years of drug abuse. By sharing these experiences with physiolog...ent more of these deaths. Deaths associated with drug abusePeople who have a history of chronic abuse of cocaine and opiate drugs have an increased risk o...Promising drug fails to improve COPD symptoms
A promising anti-inflammatory drug failed to improve symptoms of moderate to severe c...enefit in COPD patients was unexpected because the drug has proven effective in treating other inflammatory diseases, particularly rheumatoid arthritis and ...Recommended doses of ginseng, ginko biloba do not interfere with drug absorption
...icipants were given a cocktail of five drugs, each drug in the cocktail chosen because it provides a measure of the activity of a key drug metabolism pathway. Taken together, the five drugs in the cocktail provide measurements of the pathw...Heart failure medication does not improve survival, compared to more widely used medication
The drug levosimendan did not improve survival for patients...vious study, secondary analyses indicated that the drug levosimendan was associated with lower risk of death compared to dobutamine. Alexandre Mebazaa, M....Other highlights in the May 2 JNCI
...re effective at slowing tumor growth than a single drug or combination of two drugs. The tumors grew after 49 days in mice that received all three drugs, compared with 21 days for mice in the estrogen-only group and 28 days for mice that got estrogen and pertuzumab. The addition of tamoxifen to any of the...Combination treatment stymies breast cancer growth
... "These tumors are initially highly sensitive to a drug known as trastuzumab or Herceptin, one of the drug...s was much less effective. A clinical study using drug combinations in newly diagnosed patients with HER-2 positive breast cancer will start soon under t...Study raises new treatment possibilities for cognitive disorders
... with smoking. "We'd like to see this lead to a drug that would address specifically the cognitive deficits found in schizophrenia," said Kelvin W. Gee, professor in the Department of Pharmacology, School of Medicine at UC Irvine. Some examples of such deficits include difficulty concentrating and adap...OCT1 required for therapeutic effects of diabetes drug Metformin
The drug metformin is among the most widely prescribed drug...nt regimes that ensure administration of the right drug for the right person at the right time. They conclude that "tailoring therapeutic choices to the ind...JCI table of contents: May 1, 2007
... OCT1 required for therapeutic effects of diabetes drug Metformin The drug metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes and results...Young Australian scientist honored at international meeting
...uses this resistance andwhat can be done to manage drug resistance in leukaemia patients. With thisknowledge, doctors will be able to devise more effective treatment strategies forpatients." Ms Bachmann will be completing her PhD in early 2008 and hopes to continue inchildhood cancer research....Studies suggest investigational agent reduces disease activity in MS
BOSTON A new drug under investigation shows a reduction in disease a...nual Meeting in Boston, April 28 May 5, 2007. The drug reduced disease activity as indicated by MRI scans. Both of the studies involved people with the r...'Wrapping' Gleevec fights drug-resistant cancer
...ssue of Cancer Research finds that the anti-cancer drug Gleevec is far more effective against a drug-resistant strain of cancer when the drug wraps the target with a molecular bandage that seals out water from a critical area. The research ap...Your brain and hormones may conspire to make you fat
... loss he will review the development of MK-0557, a drug designed to decrease food intake. MK-0557 blocks t... clinical trials. Many lessons in neurobiology and drug development were learned from this progression of studies, the topic of the lecture....Simple screening can help decrease teen risk behaviors
...nts who engage in one form of risky behavior, like drug or alcohol use, are likely to engage in other risky behaviors like self-harm, or having unprotected sex, but often times these behaviors are not discussed during a medical or mental health exam. Now, a new study shows that a simple and brief screenin...Alzheimer's, Parkinson's, type 2 diabetes similar at molecular level
...ntially for treating them through "structure-based drug design," said David Eisenberg, a UCLA chemist and molecular biologist who is part of the research team. The researchers studied the harmful rope-like structures known as amyloid fibrils--linked protein molecules that form in the brain. The fibrils ...Drama can help educate and motivate, research shows
...al of the project was to educate the audience that drug abuse is a disease. The play also educated partici...rticipants who strongly or somewhat disagreed that drug use is a disease prior to the play, nearly half changed their opinion to somewhat agree and strongly...Resistant HIV quickly hides in infants' cells
... been made in limiting transmission with antiviral drug therapies before, during, and following birth. In...ission affects the responses of infants to various drug treatments. The study, conducted by Deborah Persaud, MD, of Johns Hopkins University School of M...Study suggests antithrombotics cause more intracerebral hemorrhagic stroke deaths in 'over-75s'
...sociated with antithrombotic (anti-blood clotting) drug use. Whilst only 4% of patients with intracerebral haemorrhage were taking antithrombotic drugs in the 1981-85 study, this proportion had increased to 40% by the 2001-06 study. This increased use could explain the absence of the expected fall in r...Review finds ways of helping children of drug and alcohol misusers
...Treatment suggests how children whose parents have drug or alcohol problems can be protected from the cons...childs resilience. "The children of people with drug or alcohol problems usually suffer very badly," said Professor Richard Velleman from the Mental Heal...Howe School lecture -- Changing the Management of Drug Safety and Pharmacovigilance, May 3
...ance and quality systems. His strong background in drug development, regulatory and industry affairs compl... means. Such is the case of pharmacovigilance and drug safety. Despite years of dealing with issues of adverse event management and reporting, the regulat...