Giving children access to drug clinical trials is crucial, clofarabine approval shows
...le agent trials. "Because of clofarabine's proven efficacy as a single agent, we now plan to offer regimens i...ks of genes. The drug was developed to improve the efficacy and minimize the toxicity of two similar drugs, cladribine and fludarabine. The other author of thi...Treating children with chronic hepatitis C
...Hospital Wuppertal, Germany sought to evaluate the efficacy and tolerability of the therapy in infected children based on HCV genotype, liver enzyme tests, and route of disease transmission. The researchers recruited 62 children ranging in age from 2 to 17 years, of mixed genders and races, all with chronic h...FDA approves Boostrix a new US vaccine for adolescents against pertussis
... and Acellular Pertussis Vaccine Adsorbed] in whom efficacy against pertussis disease was demonstrated in a pr...munization with a DTaP vaccine (Infanrix), in whom efficacy against pertussis disease was previously demonstrated The overall safety profile was comparable be...CONRAD receives $24 million from Gates Foundation and USAID for HIV microbicide trials
...nd all sub-Saharan countries, a microbicide of 50% efficacy and 20% service coverage would prevent 2.5 million new infections, leading to $3.7 billion in direct cost savings to health systems and indirect cost savings through increased productivity. CONRAD and FHI, the primary organizations conducting these ...Stents that release medication appear more effective than traditional stents
...ndomized trials to assess the safety and long-term efficacy of sirolimus-eluting stent implantation in patients with acute ST-segment elevation (a certain measurement on an electrocardiogram) myocardial infarction (STEMI), in conjunction with the expected financial consequences, currently limit use of sirolim...Long-term outcomes promising for patients with localized, low-grade prostate cancer
...ndomized controlled trials designed to measure the efficacy of screening and treatment for prostate cancer can we answer questions concerning which patients may truly benefit," the authors conclude. (JAMA. 2005;293:2095-2101. Available post-embargo at JAMA.com ) Editor's Note: This study was funded by a gra...New treatments for common vaginal infection being studied
...tibiotics used routinely in the United States. Its efficacy rate may be equivalent or better than the existing drugs, clindamycin phosphate and metronidazole, Dr. Ferris says. We have had the same two antibiotics for a long time so our treatment options are rather limited, says Dr. Ferris, who is excited abou...Digestive Disease Week 2005 spotlights breakthrough research in digestive health
... diseases Technological advancements and improved efficacy in diagnosing GI disorders DDW is jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA), the American Society for Gastrointestinal Endoscopy (ASGE) and the Society f...Hyperhidrosis and its treatment becoming better understood
...r attention from physicians. This is improving the efficacy of treatment and minimizing its adverse effects, Mayo Clinic authors write in the May issue of Mayo Clinic Proceedings. Hyperhidrosis is one of the oldest known dermatologic conditions that even today is misconceived as rare and untreatable, says Joh...New procedures more accurate in early diagnosis of GI cancers
...he University of Mainz in Germany investigated the efficacy of chromoendoscopy (CE) in conjunction with confocal endomicroscopy in the detection and in vivo diagnosis of precancerous lesions and CRC. Chromoendoscopy is the topical application of stains or pigments to improve images during endoscopy. Confoca...Those at high-risk for skin cancer burnt by own behaviour
...aviour of melanoma patients in order to assess the efficacy of sun-awareness and protection campaigns. "Patients with a personal or family history of melanoma, or that burn easily in the sun, are considered high-risk for melanoma, and should take extra care in the sun," says Dr. Beatrice Wang a dermatologist...An alternative to prevent UC-associated colon cancer
...lity in ulcerative colitis depends not only on the efficacy of surveillance or chemoprevention, but also on complication rates, costs, and quality of life of the patient, says lead author Joel Rubenstein, M.D., M.Sc., a lecturer in the Division of Gastroenterology and Hepatology in the Department of Internal ...Antibody combined with cancer drug shows promise against breast tumors
...arch. "This antibody could enhance the therapeutic efficacy of the drug docetaxel in breast cancer patients," ...tly investigating whether the enhanced therapeutic efficacy with 3G4 and docetaxel extends to other tumor models and other conventional therapies," Dr. Thorpe s...New methods offer alternatives for patients undergoing obesity surgery
...tal de Clinicas Caracas looked at the feasibility, efficacy and safety of endoluminal gastric suture, as well as its effect on reducing a patient's body mass index (BMI) and co-morbidities. Ten overweight patients were clinically examined and their baseline BMI and comorbidities were recorded. All 10 patie...Biologic therapies for bowel disease show promise in clinical trials
...le to gastroenterology and explores the safety and efficacy of a personalized treatment for Crohn's disease by...rchers from the Mayo Clinic assessed the long-term efficacy and safety of adalimumab in an open-label study of patients with active Crohn's disease. Results sh...Cutting-edge technologies signify a new era for colorectal cancer screening
...ments and an overall improvement in the diagnostic efficacy of colon screening." Onco-LIFE Fluorescence Imagi...e light imaging. This study evaluated the device's efficacy in reducing the polyp miss rate and its ability to discriminate between types of tumors. Results su...ESC releases new chronic heart failure guidelines
...es such as CHARM and VALIANT have demonstrated the efficacy of Angiotensin Receptor Blockers (ARB). ARBs are increasingly used in routine management and reflect the impact of the newer documentation. "These Guidelines also recognise the impact of the extensive co-morbidity in this population, the importance ...Arthur Frommer tells America where to stop when they need to go
...nate. It offers a unique M3 profile with sustained efficacy and low rates of central nervous system and cardiovascular side effects. Enablex works by blocking the M3 receptor that is primarily responsible for bladder muscle contraction. Enablex has been studied in 98 clinical trials involving more than 10,5...Steroid-free regimen with CellCept found comparable to standard therapy in liver transplantation
...llCept (mycophenolate mofetil) provided comparable efficacy and safety to a standard steroid-containing protoc...transplant recipients, is designed to evaluate the efficacy and safety of a regimen of CellCept with either sirolimus or standard calcineurin inhibitors (CNI). ......ide has toxic effects, but you have to balance the efficacy of the drug against its toxicity. It's a desperate disease, and nothing else has proven effective. We feel the benefits outweigh the risks." Next, Dr. Tashkin and his co-investigators hope to study a combination of cyclophosphamide and another drug t...