JCI table of contents -- May 17, 2007
...ues, however this approach has been limited by the fact that few of the injected cells accumulate at sites of tissue damage. In a study appearing online on May 17 in advance of publication in the June print issue of the Journal of Clinical Investigation, Grard Tobelem and colleagues from Institut des Vais...Quality versus quantity -- transforming kidney transplant policy
... rather than through careful matching, despite the fact that there is little risk of immediate death from renal ailments. As a result, donated kidneys in excellent condition may be given to patients who are almost certain to die long before the replacement organ wears out, while patients with longer life ...Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys
...ne serum instead of the cellular aggregates. The fact that the injection into the striate area of neurotrophic factors (those that favour cell growth), such as GDNF, also causes a significant increase in dopaminergic neurones in this region of the brain indicates that the beneficial effect produced by t...Obesity increases risk of injury on the job
...modifiable risk factors, but we cannot neglect the fact that our study and other recently published studies support an association between BMI and the risk, distribution and prevalence of workplace injury," said Keshia M. Pollack, PhD, MPH lead author of the study and an assistant professor in the Bloombe...Exercise may lead to improvement in patients with Parkinson's
...ur animal model of Parkinson's disease support the fact that exercise is beneficial for patients with Parkinson's," says Jakowec. "Exercise may help the injured brain to work more efficiently by allowing the remaining dopamine producing neurons to work harder and in doing so may promote stronger connectio...A self-fulfilling prophecy in bleeding stroke?
...ospitals in Texas over a three-year period. The fact that early limitations on patients' care were associated with such a large difference in mortality risk surprised the researchers. It's such a large effect that they say it should probably be considered when doctors use risk-calculation tools to pred...DALYs system for 'measuring' disability
...son without a disability. "The fear is that this fact will drive resources away from disabled people, making them even more vulnerable and disadvantaged than they already are in many societies." With the ICF approach, the medical condition does not matter; however functional status does in particular...New relief for unexplained chest pain
...mergency rooms and physicians' offices despite the fact that the ailment has no definable pathology. Although this pain may sometimes be the result of acid reflux disease, when this is absent most patients present hypersensitivity of the esophagus, and a recent study suggests a potential new way of managi...Machine preservation may promote more organ sharing
...d storage preservation techniques. Despite the fact that the machine-preserved kidneys were out of the body for a longer period of time (a mean of 24 hours versus 19 hours for the cold stored organs), both groups of recipients had similar survival and functional outcomes. In addition, the patients rec...New research disproves belief that group psychotherapy extends the lives of cancer patients
...methodological and analytical flaws, including the fact that they were not designed to test the hypothesis that psychotherapy extends the lives of cancer patients. The study investigators had redefined the purpose of their studies after looking at their data a practice that is generally not acceptable in...Early onset of poor bone mineralization revealed in children with cystic fibrosis
...uals," said Dr. Sermet-Gaudelus. "Accordingly, the fact that many of the children with CF in our study were smaller than average for their age might have biased our findings. To compensate for differences in body size, bone mineral density was based on height-adjusted rather than chronological age. Lumbar...Parents can sneak veggies into kids' diet
...showed no clear preference for either dish. The fact that we got the reduction in caloric intake is absolutely great, said Rolls. And the increase in vegetable intake suggests a strategy for improving diet quality, she added. Leahy, however, notes that parents should still actively promote the consum...Secondhand smoke increases risk of dementia
...inically diagnosed cardiovascular disease. "The fact that there were more people in this study population who were not diagnosed, but had underlying cardiovascular disease compared to people who were diagnosed points to the health risks associated with lifetime exposure to secondhand tobacco smoke in a...Assessment model based on medical history gauges lung cancer risk
...t the model focuses only on Caucasians, due to the fact that there were not enough minority patients in the cohort to build and validate the model. "We are currently working with other institutions to combine our numbers and build a model specifically for Mexican Americans and African Americans. In prelim...LAP-BAND System surgery improves insulin resistance
...esistance. These improvements occurred despite the fact that patients were still clinically obese. Rapid improvements in insulin resistance after surgery will have a positive impact on long-term patient health and may delay or prevent progression to diabetes....'Wrapping' Gleevec fights drug-resistant cancer
...the compound WBZ-7 based on their initials and the fact that it was the seventh compound they'd made together. Following the drug's synthesis, a second team of M. D. Anderson researchers, led by Lopez-Berestein, a professor in the Department of Experimental Therapeutics, and including Angela Sanguino an...Medicaid patients with lupus travel farther to see specialists
...en seen by a specialist. But this may reflect the fact that university centers are more willing to accept patients with Medicaid, and that patients face barriers in accessing care closer to home. Future studies may investigate the potential downstream effects of limited access on healthcare quality an...Biofeedback on abnormal mechanics lowers risk for stress fractures, pain under kneecap
...land harder when each foot hits the ground, and in fact about half of the at-risk runners who have completed the study so far already had experienced microfractures. During their retraining sessions, the runners wore a shock measuring device on their lower legs while they ran on a tread mill. A monitor on...Study puts us one step closer to understanding the function of sleep
...al, but that role remains elusive. Based on the fact that sleep seems to "consolidate" memories, many neuroscientists believe that sleeping lets us rehearse the day's events. Tononi agrees that sleep improves memory, but he thinks this happens through a different process, one that involves a reduction......ow they had the infection. This was despite the fact that over two thirds of these men said they had been to a sexual health (GUM) clinic within the past year. Almost one in five (18%) of HIV negative men and over a third (37%) of HIV positive men said they had had unprotected sex with more than one ...