Role of TRPM8 in the development of prostate cancer
...tiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells. The authors hypothesize that the constant activity of ER-TRPM8 may be the result of the expression of a truncated form of TRPM8. The authors suggest that specific inhibition of ER-TRPM8 or PM-TRPM8 ...JCI table of contents -- May 17, 2007
...tiation state of the cell, and may be an important factor in controlling the growth of prostate cancer cells. The authors hypothesize that the constant activity of ER-TRPM8 may be the result of the expression of a truncated form of TRPM8. The authors suggest that specific inhibition of ER-TRPM8 or PM-TRPM8 ...Female auto crash rates increase alarmingly; airbags can be dangerous for tall and small people
...taller than 63. Body weight was not a contributing factor to injury rates. Since many smart airbags use body weight to determine how the airbag deploys, these data suggest that a new method needs to be found. According to the author, In this 11-year sample of drivers and front passengers, occupants of small...Smoking and sleep top the list of lifestyle factors impacting oral health
...st. The study found that the number one lifestyle factor that independently impacted the progression of per...of sleep was identified as a significant lifestyle factor that may play a role in the progression of periodontal disease. The participants who received seven...Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys
...robably due to the action of the GNDF neurotrophic factor containing the cells of the implanted carotid body. In this manner, the GDNF released to the striate area will increase the number of intrinsic dopaminergic cells and these, in turn, on releasing dopamine, will result in an improvement in the conditi...UC Irvine researchers reveal first images of brain changes associated with memory
...lly reversed through treatment with a brain growth factor released at synapses. Ampakines, a new class of dr...sease and ADHD, increase the levels of this growth factor and potentially emerge as therapy for the cognitive problems associated with Huntingtons. The res...Will the healthcare workers go to work during disasters?
...ing infected. Media hype has increased the fear factor concerning influenza pandemics with reports of almost 50% mortality rate, but many experts believe the real mortality rate may be closer to the pandemic of 1918 at less than 5%. Lack of accurate information is likely to cause many more workers to sta...Reducing cardiovascular disease risk factors when discontinuing hormone replacement therapy
...e approach is both safe and effective for CVD risk factor reduction in postmenopausal women, especially those who discontinued HRT use." She continues, "CVD continues to be the leading cause of morbidity and mortality among women in westernized countriesConcern about the possible risks associated with HRT...Full-term, low-birth-weight babies at significantly greater risk for early respiratory symptoms
...ncluded that low birth weight is an important risk factor for the development and persistence of respiratory symptoms during preschool and early elementary school. The association was strongest at age 4 but had no effect after age 6. "In addition, all parents should be strongly encouraged to stop smoking ...Obesity increases risk of injury on the job
...urer to determine whether increased BMI was a risk factor for workplace injury. The plants were scattered across the United States. BMI was calculated using National Institutes of Health criteria. Employees were grouped into five categories: underweight, normal, overweight, obesity levels I and II and obesi...Tobacco and alcohol use independently increase risk of head and neck cancer
...t to tease out the independent effect of each risk factor on head and neck cancer development. Mia Hashibe, Ph.D., of the International Agency for Cancer Research in Lyon, France, and colleagues examined head and neck cancer risk among smokers who never drank alcohol and people who drink but never used t...Study finds women less likely than men to have their cholesterol controlled
...ed LDL cholesterol is an important modifiable risk factor for cardiovascular disease, the leading single cause of death for both women and men. The study, "Improving the Quality of Care for Cardiovascular Disease: Using National Managed Care Performance Data to Investigate Gender Differences in HEDIS Measur...Mediterranean diet halves risk of progressive lung disease
...ldwide by 2020, with cigarette smoking the primary factor in its development. The researchers tracked the health of almost 43,000 men, who were already part of the US Health Professionals Follow up Study. This began in 1986 and involved more than 50,000 US health care professionals aged between 40 and 75,...Breastfeeding duration rates for infants born in an inner-city WHO/UNICEF Baby-Friendly hospital
...r studies have concluded that demographics usually factor into poor breastfeeding duration rates in low-income, black populations, this study found that those mothers who gave birth in a Baby-Friendly hospital breastfed at rates comparable to the overall US population, suggesting that the Baby-Friendly init...A self-fulfilling prophecy in bleeding stroke?
...laced on their care, the results show that a major factor has been overlooked in the way ICH patients' survival is calculated. Until ICH scoring tools can be adjusted, "this suggests that physicians should be more humble about our ability to predict an ICH patient's prognosis, particularly in the first d...Quick, innovative procedure helps men minimize incontinence after prostatectomy
...Too often, the threat of incontinence can be a key factor in a patient's decision for or against prostatectomy," Dr. Vaughan adds. "A simple intervention like this could make that choice a lot easier." Prostatectomy involves the excision of the prostate gland, as well as some adjacent tissue, depending on...Patients with 'bleeding' strokes less likely to get prevention treatment
...d stroke. Smoking, in particular, is a known risk factor for both bleeding strokes and ischemic strokes. They found that 77 percent of ischemic stroke patients received cholesterol-lowering medications at discharge, compared with 67 percent of ICH patients and 62 percent of those with SAH. "It is uncertain...Use of Swedish 'snus' is linked to a doubled risk of pancreatic cancer
...al The Lancet. Tobacco smoking is a known risk factor for pancreatic cancer, which is an unusually malignant form of the disease. Since it is common for people who take snus a tobacco product designed for insertion between the gum and upper lip to also smoke cigarettes, the challenge facing epidemiolo...Breakdown of myelin implicated in Alzheimer's, UCLA research shows
...possibility that brain iron levels might be a risk factor for age-related neurodegenerative diseases like Alzheimer's. In the study, he suggests that myelin breakdown in the late-myelinating regions releases iron, which promotes the development of the toxic amyloid oligomers and plaques, which in turn destr......ound that oral HPV infection is the strongest risk factor for the disease, regardless of tobacco and alcohol use, and having multiple oral sex partners tops the list of sex practices that boost risk for the HPV-linked cancer. Study author and cancer virus expert Maura Gillison, M.D., Ph.D., first reporte...