Randomized trial of two therapies for acute lymphocytic leukemia finds survival advantage
...ciety for Clinical Oncology. "There have been very few randomized trials in adult ALL. This is probably the first study in 20 years that focuses on induction therapy, and it appears to show that one treatment is superior to another in putting the disease in remission," explained Dr. Weiss. "Although the ...New therapy may give options to those with neuroendocrine tumors
...g. Carcinoid and pancreatic islet cell tumors have few tolerable, successful treatments, says medical oncologist Heinz-Josef Lenz, M.D., associate professor of medicine at the Keck School of Medicine of the University of Southern California and co- principal investigator on the trial. "Other than surgery...Nutrition gene key in regulating immune system
...rocess." So the researchers started looking at the few genes known to respond to amino acid levels and found GCN2. GCN2 is present and active in many cells, but its major sites of action are unknown and its role in T cells was unexplored, Dr. Munn says. "GCN2 is a nutrition sensor in yeast," says Dr. Mu...Researchers find way to streamline new non-Hodgkin's lymphoma treatment
...homa patients since the early 2000s. However, in a few patients, the medication goes to the wrong tissues. That means that physicians are required to perform numerous imaging scans to monitor patients at the start of therapy, a process that lengthens and complicates treatment.If physicians could quickly ...Jefferson researcher's results show promise for metastatic eye melanoma
...oma of the eye spreads to the liver, patients have few good options. Surgery is frequently impossible, an...e and his team conducted.Dr. Sato heads one of the few programs in the nation treating metastatic uveal melanoma, which is a melanoma originating in the ey...Exercise reduces risk of recurrence and death in early stage colon cancer patients
...ogging two to three hours a week, playing tennis a few times a week, or walking briskly an hour a day six times a week, explains Meyerhardt, who is an assistant professor of medicine at Harvard Medical School. The study involved patients reporting leisure-time physical activity approximately 12-18 months...Zevalin safe and effective for non-Hogdkin's lymphoma patients with advanced disease
...y and have received stem cell transplantation have few treatment options available," said Samuel Jacobs, M.D., lead investigator and associate director for clinical investigations at the University of Pittsburgh Cancer Institute and UPMC Cancer Centers. "As a result, it is crucial to evaluate novel thera...Timing of introduction of gluten into infant's diet associated with appearance of celiac disease
...es have increased risk of celiac disease. However, few genetically susceptible individuals develop celiac disease, even though virtually all individuals in wheat-consuming populations are exposed to gluten. This suggests that additional factors play a role in disease risk. Jill M. Norris, M.P.H., Ph.D., ...Cognitive function and compliance with Seroquel examined in separate studies in schizophrenia
...ficant barrier to long-term recovery. 1 To date, few studies have directly compared atypical antipsychotics for the treatment of cognitive function. 1 Data presented today, drawn from an 8-week, double-blind, flexible-dose, parallel study of 673 schizophrenia patients randomized to treatment with SER...Ramelteon demonstrates no abuse potential according to study results
... million Americans suffer from insomnia at least a few nights per week. Most currently prescribed sleep agents and some investigational drugs work by targeting gamma-aminobutyric acid (GABA) receptors, which are located throughout the brain. In pre-clinical studies, ramelteon has shown no affinity for G...New Seroquel data show significant improvement in compliance and cognition in schizophrenia
...th SEROQUEL. The compliance study is one of the few to compare both atypical antipsychotics with each other as well as with typical antipsychotics in schizophrenia. The findings show SEROQUEL to have the highest compliance rate of both typicals and atypicals, which was significantly (P<0.05) great...Relationships improve quality of life for prostate cancer patients
...hips may provide an alternative to support groups, few studies have evaluated the impact of partnerships on quality of life. Led by John L. Gore, M.D. of the University of California, Los Angeles, researchers investigated 291 men from low socioeconomic strata diagnosed and treated for prostate cancer to ......ce and others no longer seemed important. Just a few months before prior to the terrorist attacks a s...attack at some point in Franklin County . However, few respondents believed the 9/11 attacks changed their homeownership plans in any way. Still, despite ...Tobacco use persists after liver transplant for alcoholic liver disease
...plant were found to be nicotine dependent. Only a few associations were found between smoking and demographic and medical characteristics in the transplant population. Recipients who also had hepatitis B virus or hepatitis C virus were more likely to smoke, as were those with a history of abusing substa...Physical activity associated with improved survival for women with breast cancer
...ancer could potentially improve survival, although few data exist to support this hypothesis. Michelle D. Holmes, M.D., Dr.P.H., of Brigham and Women's Hospital and Harvard Medical School, Boston, and colleagues conducted a study to examine whether higher levels of physical activity after a breast cancer...Protein essential for hearing also vital for pain perception
...could block TRPA1 would be novel pain killers with few or no side effects, although targeting the inner ear may have to be avoided, said Jaime Garcia-Aoveros, who led the research. Garcia-Aoveros, assistant professor of anesthesiology, neurology and physiology at Feinberg and the Northwestern University...Medical privacy vs. health care quality?
... who have not returned their consent forms after a few weeks. They can ask if the form has arrived and to offer to send another if it has not. If asked, they can explain what the study involves, and can encourage willing participants to send their consent forms back so that a researcher can call them. B...Survey of academic medical centers' standards for clinical-trial agreements with industry
...ngs. Lead author Michelle Mello wrote, "We found a few areas of consensus and many differences among the institutions in what they viewed as acceptable or unacceptable provisions in agreements with industry sponsors of clinical research. The variation raises the possibility that industry sponsors could ...Post-marketing analysis examines cholesterol-lowering drugs' side effects
...(mg) dose or less. Fatalities occurred in only a few cases, with death rates in patients taking rosuvastatin and simvastatin being lower than the other statins (pravastatin and atorvastatin). Karas said post-marketing analyses like this one can help identify safety concerns that might be missed by pre......al ultrasound sensors. Each sensor is as wide as a few human hairs. "It took a craftsman to create this probe," said Smith. "Not many graduate students could have done what Chris Pua has done." "Maintaining the size of normal TE probes was a main factor in the design since 3-D imaging inherently requires...