Reductive stress linked to heart disease
...rone, normally helps long strips of other proteins fold inside cells. When it works properly, the cell produces the correct amount of reduced glutathione, which is healthy for the body. Unfortunately, when the gene that makes alpha B-Crystallin is mutated in humans, the protein unfolds improperly into agg...Researchers link metal ions to neurodegenerative disease
..."Amyloid is made of proteins and proteins normally fold into beautiful structures. However, for whatever reason, some misfold and the resulting misfolded structures are also beautiful, but sticky. They stick to themselves and then propagate to form fibrils, but only some of the fibrils turn out to be toxi...UD scientists invent novel hydrogels for repairing, regenerating human tissue
...ids are bonded together to form chains, which then fold up into more compact shapes with specific function...gered self-assembly, meaning that the peptide will fold automatically into a specific shape in response to a particular trigger, or environmental stimulus, ...FPG receives $8 million for autism research
...children diagnosed with autism has sky-rocketed 20 fold by some estimates. This rapid increase has placed great demand on early intervention and education agencies to provide effective educational and intervention services for children and their families. Research shows that if we intervene early, we ca...MU researchers find mechanisms that may unlock answers to Alzheimer's disease
... protein comes together inside the plaque, it will fold into an abnormal shape that is toxic to cells, Sun said. While we know this has some effect on brain function, we dont know how toxic it is or at what stage the toxicity begins. In the past five years, we have started to understand how this disease w...Asthmatx completes enrollment in pivotal study of bronchial thermoplasty
...puffs/week of short-acting bronchodilators, 2.6 fold increase in days with no asthma symptoms, from 3 months with no asthma symptoms to 8 months with no asthma symptoms, Clinically significant improvements in both asthma quality of life and asthma control. In the period immediately following bro...Study demonstrates long-term durability of Plicator procedure
...he Plicator to restore the anti-reflux barrier, "a fold over the top part of the stomach that acts to prevent acid and other stomach contents from going up into the esophagus which then reduces symptoms," says Pleskow. The study involved 29 patients with chronic heartburn who required daily maintenance ...Smoking worsens knee osteoarthritis
... The investigators found current smokers had a 2.3 fold increased risk of cartilage loss at the medial tibiofemoral joint and a 2.5 fold increased risk of cartilage loss at the patellofemoral joint compared to the men who had quit smokin...Study of NYC transit system noise levels finds daily rides can result in hearing loss
...re of decibels means that every 10 dBA equals a 10 fold increase in intensity. Thus a 90 dBA sound is 10 times as intense as an 80 dBA sound. "Several factors have the potential to contribute to hearing loss, including years of ridership, frequency of ridership, and length of rides," observes Dr. Gers...Muscle cells self-destruct rather than grow with use
... heat shock protein 70, which helps other proteins fold and function properly. The BAG family also has an anti-death function called antiapoptosis. Dr. Takayama is still dissecting the relationship between the anti-death function and BAG's regulatory role with the heat shock protein. "If protein folding ...3-D forms link antibiotic resistance and brain disease
...enzymes consist of two strands of amino acids that fold into various twists and turns to make a complex 3-...uite different 'strings' of amino acids. But they fold up into virtually identical looking 3-D monomers. "It was as if the uniqueness of each structure dis...Washington University researchers find almost half of kids with ADHD are not being treated
...ber of adolescents taking ADHD drugs increased 2.5 fold between 1990 and 1995. And many reports have noted a rapid increase in the U.S. manufacture of the stimulant drug methylphenidate -- usually sold under the brand names Ritalin or Concerta. The researchers studied 1,610 twins between the ages of 7 a...No-hands origami: New DNA self-assembly makes more complex structures, more easily
...has developed a way to "program" strands of DNA to fold themselves into a variety of complex shapes an ac...nd uses short, complementary strands as staples to fold and keep the scaffold in place. In Rothemunds one-pot approach, "the scaffold is already perfect; al...Inflammatory biomarker helps identify progressive precancerous lesions in the lung
...he odds of developing progressive disease were 9.6 fold higher in the group that had CRP greater than 0.5 mg per liter compared with the group less than this threshold," said Dr. Lam. There were 32 subjects whose bronchial lesions had progressed to a more abnormal state when biopsied after 6 months. "Thes...Nanoscale study gives new insight into heat transfer in biological systems
.... In water-based solutions, proteins instinctively fold into unique three-dimensional structures, which do much of the work in the body. Misfolded proteins also are implicated in diseases such as Alzheimer's and Parkinson's, and the ability of proteins to function depends on how much they can vibrate in t...Antipsychotic treatment of dementia leads to small increase in risk of death
...h stated that there was "an approximately a 1.61.7 fold increase in mortality" in studies of these drugs, with most due to either heart-related effects like heart failure or sudden death, or infections such as pneumonia. There are, of course, caveats regarding these results. For instance, most of the stud...Sexes differ in their immune reactions to burnout on the job and depression
...tudy who scored higher on burnout scores had a 1.6 fold risk of having an elevated level of CRP (>3), ...or their levels of burnout and anxiety) had a 3.15 fold risk of having an elevated level of CRP (>3), and elevated levels of fibrinogen compared to the ...New online atlas provides collective maps of human brain folds
...le." For example, Van Essen's study showed that a fold in the temporal lobe is deeper in the right hemisphere than it is in the left. The fold is involved in such tasks as combining information from vision and hearing. Van Essen's lab is curr...Enhanced imaging techniques could improve medical diagnosis
... good. Sometimes, though, the polyps can hide in a fold and finding them can be difficult. If we can use virtual colonoscopy to help guide the endoscope to the polyps, we can help the endoscopists become even better and faster." While earning his Ph.D. at the Wake Forest University School of Medicine, Wya...Special scalpel reduces blood loss, facial nerve trauma in salivary surgery
... standard approach is making an incision in a skin fold in front of the ear that runs back into the hairline the same as for a facelift then using surgical scissors to remove the gland and surgical ties or electrocautery to stop bleeding. A small pilot study published in Otolaryngology Head and Neck Su...