Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
...ansferrin, a plasma protein found in blood, can be fused with large, protein-based drugs such as granulocyte colony-stimulating factor (G-CSF) to create a new oral compound that is capable of surviving the journey through the gastrointestinal (GI) tract and then able to cross over into the bloodstream to b...Backyard treatment may yield leukemia treatment
...ng cell division. The translocation creates a new, fused gene (called BCR-ABL), that produces a cancer-causing enzyme called Bcr-Abl. Bcr-Abl permanently "turns on" cell growth signals that are normally held in check by molecules called phosphatases, and the result is the uncontrolled production of white b...Connective tissue cells from lungs fused with heart muscle to form biological pacemaker
...n guinea pig experiments, Johns Hopkins scientists fused common connective tissue cells taken from lungs wi...kin. "They proliferate well and grow fast and when fused with heart muscle, form cells that are very stable. Thus, our method would seem to the safest and mo...Stanford study of sea squirt provides clue to human immune system
...tem cells, which transplant themselves between the fused individuals through the shared circulatory system. Eventually one set of stem cells overpowers the other, going on to replace the tissues of the loser. It was the fusing process, body-snatching tendencies notwithstanding, that attracted De Tomaso's i...New evidence supports century-old theory of cancer spread
...as astonishing," said Pawelek. "In culture dishes, fused cells were extraordinarily motile compared to unfused melanoma cells. They spread rapidly when implanted in mice. Even though the idea is virtually unknown to cancer researchers today, many scientists worked on it in the 20th century. From the late 1...New studies identify advances in treatment of chronic myeloid leukemia
...akpoint cluster region) gene from chromosome 22 is fused with part of the ABL (abelson leukemia virus) gene on chromosome 9. The translocation takes place in a single bone marrow cell and, through the process of cell division and expansion, results in leukemia, the rapid growth of abnormal white blood cel...TRAF3 protein is a key part of the early immune response to viruses
...tificial gene that coded for the TLR adaptor MyD88 fused to a molecule called gyrase B. In the presence of ...ormation of pairs of the MyD88 molecules that were fused to gyrase B. This reaction, which produced pairs of MyD88-gyrase B complexes, then triggers recruit...Antibody therapy promising for pediatric neuroblastoma
...iferation. The Fc protein (immunoglobulin) that is fused to IL-7 slows the process by which the body disposes of this cytokine. The researchers isolated the gamma-delta-T lymphocytes from blood samples obtained from healthy human volunteers. While the hu14.18 antibody does not directly kill neuroblastoma ...Smoking while pregnant causes finger, toe deformities
... digits on the hands or feet. Syndactyly is having fused or webbed fingers or toes. Adactyly is the absence of fingers or toes. Webbed fingers or toes occur one in every 2,000 to 2,500 live births and excess fingers or toes occur one in every 600 live births. Webbed fingers or toes occur twice as often in ...Combining PET and CT scans makes cancer treatment more accurate
... radiation and lower recurrence rates. The doctors fused images captured from both the PET and CT scans and found that the proposed treatment plans were very different in 14 of 16 patients whose plans had been designed using CT scanning alone. Out of the 28 patients who were followed for more than six mont...Jefferson scientists show 'miracle' cancer drug Gleevec can be toxic to the heart
...ood cell development. The genes ABL and BCR become fused and produce a hybrid BCR-ABL enzyme that is always active. The overactive BCR-ABL, in turn, drives the excessive proliferation of white blood cells that is the hallmark of CML. According to Dr. Force, 10 patients taking Gleevec at the University o...New drug target might sidestep gleevec resistance, Jefferson scientists show
...ood cell development. The genes ABL and BCR become fused and produce a hybrid BCR-ABL enzyme that is always...tists used an inactive C/EBP-alpha protein that is fused to an estrogen receptor. The protein can only be activated by treating mice with a hormone, in this ...Vaginal birth increases risk of hemorrhage in newborns
... In a newborn, the bones of the skull have not fused together, so the bones of the skull can shift and frequently overlap each other during vaginal delivery, to allow the baby's head to fit through the birth canal. This shifting can compress the brain or cause blood vessels to tear, which causes bleedi...Scientists develop method to track immune system enzyme in live animals
...a green fluorescent protein derived from jellyfish fused to the AID enzyme. In these transgenic animals, B cells express the tagged enzyme during the immune response. In a second mouse strain, Casellas and coworkers expressed permanently a yellow fluorescent protein in the progeny of germinal center B cell...