Tag: "gene" at medical news
Smoking may strongly increase long-term risk of eye disease
...d hypertension. Smoking may also interact with AMD gene
susceptibility and other environmental risk factors. Jennifer S. L. Tan, M.B.B.S., B.E., University of Sydney and Westmead Hospital, Sydney, Australia, and colleagues examined 2,454 Australians age 49 and older to study the association between smok...
New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
...getown University Medical Center, indicates that a gene
previously thought to be unrelated to breast cance...that over-expression of the spliced variant of the gene
in estrogen receptor-positive breast cancer cells led to reduced sensitivity to Tamoxifen and Faslod...
Pathway links inflammation, angiogenesis and breast cancer
... oncogene's competition with the tumor-suppressing gene
p53 for access to CREB-binding protein (CBP). Both p53 and NF-kB covet CBP, an extremely popular activator of genes that interacts with hundreds of other proteins, Hung notes. In the case of the tumor suppressor and the oncogene, CBP will bind to o...
Reductive stress linked to heart disease
...h is healthy for the body. Unfortunately, when the gene
that makes alpha B-Crystallin is mutated in humans...of reduced glutathione without the altering mutant gene
encoding thee alpha B-Crystallin, , the study shows reductive stress can be addressed through new dr...
Bioengineering to prevent iron deficiency?
...two- to three-fold by introduction of the ferritin gene
from the soy bean. Another problem the reduction of bioavailable iron due to high phytate content could also be solved by introducing genes which increase the activity of phytase enzymes to break down the phytate. The authors conclude by calling ...
Green tea holds promise as new treatment for inflammatory skin diseases
... slower growth of skin cells and the presence of a gene
that regulates the cells life cycles. Psoriasis,...ed levels of proliferating cell nuclear antigen, a gene
expressed when skin cells multiply. In psoriasis, the gene
is over-expressed and speeds production o...
Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
...l mice had none. After they had silenced the gene
for TOPK in human colorectal cancer cells, growth of the cells was significantly slowed compared to control colorectal cancer cells. The researchers also found that TOPK and a related enzyme (not MEK) activated each other in growing human colo...
UCLA, Italian chemists move closer to solving Lou Gehrig's disease mystery
... and found that some of them have mutations in the gene
that codes for this enzyme. While the inherited form represents only a fraction of all ALS cases, this marked the first time there was any indication of a cause for any form of ALS, Valentine said. For many years, Valentines laboratory has studied ...
Future therapies for stroke may block cell death
...f enzymes called histone deacetylases can modulate gene
expression, and in some cases produce cellular proteins that are actually neuroprotective -- they are able to block cell death. "For the first time, we show which one of the 11 histone deacetylase enzymes might be the best target to achieve cellula...
Simple test predicts 6-year risk of dementia
...copies of the e4 allele, or subtype, of APO-E, the gene
that codes for the protein known as Apolipoprotein. The presence of APO-E e4 alleles is a known risk factor for Alzheimers disease. A best test score of 0 to 4 indicates a 4 percent chance of developing dementia within six years. A score of 5 to 8 ...
Loss of stem cells correlates with premature aging in animal study
...versity of Pennsylvania have found that deleting a gene
important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the bodys response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types o...
Low-carb diets' effects linked to rise in newly identified 'starvation hormone'
...new study, Maratos-Fliers team examined changes in gene
activity occurring in mice fed a high-fat, low-carb diet for 30 days. Their comprehensive genetic screen of the animals, which lost weight on the special diet, turned up FGF21. "We saw a dramatic increase in FGF21 in the livers of the mice [on the ...
Study identifies new regulator of fat metabolism
...active role in the process. And, using micoarray gene
analysis, they discovered that their hunch was correct: FGF21, a liver-derived fibroblast growth factor gene, was significantly increased in the mice that had been fed ketogenic diets. FGF21 had previously been identified as a potential metabolic r...
The Burroughs Wellcome Fund awards $8 million to infectious disease investigators
... California-Berkeley Global modulation of cellular gene
expression by an oncogenic human herpesvirus Karen J. Guillemin, Ph.D. University of Oregon Regulation of gut epithelial cell homeostasis by the microbiota Lora V. Hooper, Ph.D. University of Texas Southwestern Medical Center-Dallas Innate immune...
MUHC-led international team identifies gene responsible for blindness in infants and children
...eal, June 4, 2007 -- A MUHC-led study identifies a gene
responsible for Leber Congenital Amaurosis (LCA), ...ildren and then study them so that we can then use gene
therapy to rescue their vision. Working with an international team of researchers including Drs. A...
Vorinostat shows anti-cancer activity in recurrent gliomas
...as treated with vorinostat prior to surgery, and a gene
and protein analysis of their resected tumors was ...nfirmed increase in histone acetylation and showed gene
changes indicating that vorinostat reaches the glioblastoma tumors and interferes with the target pa...
Genetic mutations identified for type of gastric cancer
...astric cancer (HDGC) is caused by mutations in the gene
CDH1, and is characterized by an increased risk fo...y to assess the frequency of mutations in the CDH1 gene
and whether these mutations occurred due to independent mutational events or common ancestry. The st...
Study supports activity of GEMZAR in the treatment of early-stage breast cancer
...dition, patients who tested positive for the HER-2 gene
also were given trastuzumab (Herceptin) and demonstrated additional response. The data released today reflects our ongoing, aggressive research plan involving GEMZAR as a key therapeutic foundation for the treatment of breast cancer, said Allen M...
Mouse model points to possible new strategy for treating rare muscle disease, kidney disorders
... which is caused by a specific mutation in the GNE gene
known as M712T. Numerous other GNE mutations can c...reated a transgenic mouse model in which M712T GNE gene
mutation was introduced into a strain of mice. However, the researchers were surprised to find that,...
Brain inflammation may be friend, not foe, for Alzheimer's patients
... class of viruses known as lentiviruses for use in gene
therapy. The team used a lentivirus to boost levels of IL-1 beta in select brain regions of its engineered mouse, then applied the technology in mice specially designed to develop Alzheimers disease. The mice developed normally for six months. Then...
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