Study shows surprising decreased surgical infection risk after age 65
..., a "hardy survivor" effect, in which a protective genetic makeup may enable elderly patients to withstand the rigors of surgery and its complications. Keith S. Kaye, MD, MPH, and colleagues at Duke University Medical Center and Durham Veterans Affairs Medical Center studied 144,485 patients over age 16 year...Shape-altering genes linked to ovarian cancer
... coaxed into the different forms by changes in its genetic programming. Naora suspected that HOX genes, which direct immature embryonic tissue to form the various body structures during development, could become reactivated in ovarian cancer cells. She and her colleagues tested the effect of four HOX genes o...Northwestern's cancer genetics program finds gene variants that greatly increase breast cancer risk
...m that provides cancer predictive gene testing and genetic counseling. TGFBR1*6A testing is currently only o...testing for this gene will enter the mainstream of genetic testing in the near future. Virginia Kaklamani M.D., an oncologist at Northwestern Memorial Hospita...SKCC's Gennadi Glinsky addresses predicting risk in cancer treatment outcome
...g-up a clinical trial to evaluate the utility of a genetic test measuring the expression profiles of the 11-gene signature as a prognostic and therapy outcome marker. Gennadi Victor Glinsky, M.D., Ph.D. Gennadi Victor Glinsky, M.D., Ph.D., is an associate professor at the Sidney Kimmel Cancer Center in San D...Gene expression pattern predicts multiple drug resistance, treatment failure in pediatric leukemia
...n of gene expression, rather than acquired through genetic mutation during treatment. Cross-resistance to mul...ent outcome. "The identification of a particular genetic expression pattern linked to cross-resistance takes us a significant step forward in understanding w...Obesity adds risk of cardiovascular disease in siblings in families with a history of heart problems
...es had 15 times more premature heart disease. When genetic traits were analyzed, the Hopkins team found that ...r research is planned to verify its biological and genetic origins....Variant in gene associated with telomeres predicts longer survival of deadly brain tumor
...toma multiforme has found an association between a genetic variation and a doubling of survival rate - the strongest link ever established between genetic variation and outcome in this deadliest form of brain cancer, according to researchers at The Univer...Findings about anti-cancer agent could make it more effective
...mpound called FdUMP[10] works to damage DNA, the genetic "code" found in all cells. The results were reported in Anaheim, Calif., today at the American Association for Cancer Research's 96th Annual Meeting and will be published June 1 in Cancer Research. Eleven years ago, Gmeiner set out to develop a com...Researchers develop 'genetic blueprint' to predict response to esophageal cancer treatments
... appear to be able to use a comprehensive panel of genetic variants to predict how a patient with esophageal ...therapy to individual patients because it offers a genetic blueprint for gauging the potential effectiveness of all common esophageal cancer treatment, not jus...CML found to wield 'death factor' that kills normal blood marrow cells
...by the Philadelphia chromosome, a translocation of genetic material responsible for most CML) appears to hijack 24p3 and change it structurally to become a cell killer," he says. The secreted proteins appear to destroy bone marrow stem cells responsible for producing red blood cells as well as platelets, but...Increasing benefit seen in novel drug that treats Gleevec resistance
...ife span." CML is caused by the errant swapping of genetic material in bone marrow stem cells that produces an abnormality called the Philadelphia chromosome. This chromosome contains a new fused-together gene, BCR-ABL, which produces an enzyme that switches on uncontrolled growth in the bone marrow cell. Gl...Used in a new way, RNA interference permanently silences key breast cancer gene
...fect is achieved with RNAi before the tiny bits of genetic material are become inactive as the cell population continues to expand. "We are a long way from using this technique in patients, but this study shows that that it may be possible to use RNAi in more than just experiments that silence genes temporar...Brain imaging study explains Williams syndrome language gifts
...sis and understanding of the syndrome's underlying genetic trigger. Background: Williams Syndrome is a genetic disorder characterized by heart defects, abnormalities in the outer layer of the brain, or cerebral ...Genetic variation linked to alcohol dependence found in a Russian population
..., Conn.--The same gene that accounts for part of a genetic risk for developing alcoholism in a U.S. populatio...nvironmental factors in Russia may be at play, the genetic variations still seem to be influencing risk in that population," said Jaako Lappalainen, M.D., assi...Monoclonal antibody cures West Nile virus-infected mice
...ntibody, scientists at Macrogenics clipped out the genetic material that controls the antibody's targeting and cloned it into a human antibody. The "humanized" antibody should be less likely to induce an adverse human immune system response. A second round of tests in mice confirmed that the new antibodies ...Genetic screening for iron blood disorder feasible in the workplace
...nalysis of this programme is currently ongoing. If genetic screening is shown to be cost-effective, it should...tudy, the risks of such screening are very low and genetic discrimination need not occur." In an accompanying comment Paul Adams (London Health Sciences Centre...High risk of second cancers in survivors of childhood soft tissue sarcomas
...e radiation and chemotherapy or, in some cases, to genetic predisposition. In the current NCI study, the res...oft tissue sarcomas was consistent with underlying genetic syndromes, particularly Li-Fraumeni syndrome and neurofibromatosis type 1. The authors concluded, ...Fatal brain disease holds clues to dementia
...ill inherit the disorder, which can be detected by genetic testing. Research leader Dr Anthony Hannan said hi...environment." "Now we can better understand how a genetic change affects wiring of neurons and relate that to changes in learning, memory and behaviour in Hun...American Academy of Neurology sums up scientific highlights from 57th annual meeting
...e especially strong in those patients with a known genetic risk factor for Alzheimer's, the APOE-4 allele. In the same study, vitamin E was not found to slow cognitive decline. [plenary session] A potentially important experimental therapy for Alzheimer's disease is the use of antibodies against the beta-amy...... Bioscience are gaining valuable insights into the genetic mechanisms contributing to this startling rise in ...actors for developing testicular germ cell cancer, genetic predisposition is a key component. To date, over 80 different genes have been found to be defective ...