JCI table of contents: July 3, 2006
...gh which CSF passes. In most vertebrate species, a gland (known as the subcommissural organ or SCO) at the ...AR in balancing cholesterols levels in the adrenal gland Cholesterol is the precursor to all steroid hormones, which control heart rate, blood pressure, an...NIDCR's Turner to receive IADR Salivary Research Award
...contributed to the basic understanding of salivary gland structure, secretion, and function, or salivary co...or fluid secretion by rat parotid and human labial gland acinar cells, including their regulation by secretory stimuli. In particular, he has concentrated on...Early puberty may mean anxiety, abnormal eating behaviors later
...satile fashion. With each secretion, the pituitary gland is stimulated to secrete its own messengers, lutenizing hormone (LH) and follicle-stimulating hormone (FSH), directly into the circulation. In turn, these rising levels of LH and FSH cause the testes and ovaries to produce the sex hormones testostero...New combination therapy after surgery improves survival for pancreatic cancer patients
... are still living. Cancer of the pancreas, a large gland just behind the stomach that produces digestive juices and insulin, is the fourth leading cause of cancer death in the United States, with 32,000 people dying of the disease each year. Only 4 percent of people are still living five years after they a...Early estrogen exposure leads to later prostate cancer risk
...ental estrogens during development of the prostate gland in the male fetus may result in a predisposition to prostate cancer later in life. The study, done in an animal model, also demonstrates how the predisposition may arise, and a way to identify those at risk. Man-made compounds that can mimic the horm...Calorie restriction appears better than exercise at slowing primary aging
...geted another marker of primary aging. The thyroid gland produces critical hormones that play an indispensable role in cell growth and development as well as in lipid and carbohydrate metabolism. T4 is the main product secreted by the cells of the thyroid gland, but most actions of thyroid hormone are init...Botox: Its not just for wrinkles anymore
...ted botulinum toxin A, or Botox, into the prostate gland of men with benign prostatic hyperplasia (BPH), a ...er the injection, as the Botox caused the prostate gland to relax, putting less pressure on the urethra. Patients did not experience any significant side eff...OHSU primate center research suggests multiple 'body clocks'
...ed clock resides in the adrenal gland. The adrenal gland is involved in several important body functions, s...o conduct the research, scientists studied adrenal gland function in rhesus macaque monkeys which is very similar to human adrenal gland function. Specifical...No link between short-term testosterone use and prostate cancer, study says
...of T and DHT (the hormone that stimulates prostate gland growth) did not change from baseline at 6-months. PSA, PV, tissue biomarkers and indices for atrophy and inflammation also were unchanged after 6-months of treatment. Furthermore, gene expression was not altered, cell proliferation was not accelera...Italian researchers find fenretinide cuts the risk of second breast cancers in young women
...in different ways according to the stage of breast gland development in women. Said Dr Decensi: "Its differential effect recalls the effect of first full term pregnancy on breast cancer risk, which is protective at a young age and deleterious at an older age." He said the team wanted to initiate a preventi...Bronchial thermoplasty offers significant improvement for asthmatics in small study
... damage to the nerves or vessels, changes in mucus gland structure and function, alterations in the type of inflammation and changes in airway compliance that may modulate this effect. Thus, the debate on the relative importance of muscular and non-muscular elements in bronchial hyperresponsiveness in asth...JCI Table of Contents, April 3, 2006
...cs committee), and found that although the adrenal gland increased in size over the course of 810 weeks of development, the content of cortisol dropped by approximately 50%. Further, the authors found that individual adrenal glands from first trimester fetuses were able to produce several different androge...Minimally invasive approach can work for many thyroid patients
...ded by some, he says. This includes patients whose gland has grown too large to be removed through a small opening, even with careful manipulation of the gland that typically remains pliable when diseased. In Dr. Terris' practice, about 30 percent of patients ...OHSU research reveals the complexities of obesity/cortisol interactions
...cally restore POMC selectively in the pituitary, a gland at the base of the brain that regulates the secretion of cortisol from the adrenal glands, but not in the central portions of the brain. The second method was to directly replace glucocorticoids in POMC-lacking mice through their drinking water. "In...BRCA1 gene found to inhibit two sex hormones, not just one
...progesterone, or both, and response of the mammary gland was compared with that of normal mice. In this way, the researchers concluded that BRCA1 interacts physically with the progesterone receptor, and stops it from activating other genes. It does this even in the absence of the progesterone hormone, and,...Breast ducts: A new site for cancer treatment?
...umber of intraductal injections to two per mammary gland completely protected all 10 mice (100 glands) from developing the cancer while all intravenously treated mice succumbed to the disease. The scientists found similar results using a derivative of tamoxifen in rat models. Phase I studies in breast canc...Screening test for prostate cancer does not improve survival
...an be caused by benign enlargement of the prostate gland (prostatism) or prostate infections. To test the impact of prostate cancer screening on survival, the researchers conducted a case-control review of the medical records of over 1,000 male veterans age 50 or older receiving care at 10 VA medical cent...New drug lets thyroid cancer patients avoid nasty side effects during treatment
...y, radioiodine treatment for cancer of the thyroid gland requires temporary discontinuation of thyroid horm...cancer is first treated by surgical removal of the gland in the neck, often followed by radioactive iodine treatment to remove any remaining thyroid tissue. ...Hopkins researcher links gene mutation with poor outcomes in people with most common thyroid cancer
...remove the cancerous thyroid gland. The thyroid, a gland located beneath the voice box (larynx) that produces thyroid hormone, helps regulate body cell growth and metabolism. Results also showed that, given an average follow-up of three to four years, 25 percent of patients with BRAF mutations experienced ...Hormone aldosterone is promising target for stroke treatment
...um surrounding the hormone secreted by the adrenal gland prompted the journal to ask Dr. Dorrance to write ...s, too much aldosterone resulting from an adrenal gland tumor or abnormal production for unknown reasons is what causes problems, such as proliferation of ...