JCI Table of Contents, April 3, 2006
... to the drug's suppression of fetal levels of male hormones (adrenal androgens) produced by a critical determinant of gender known as the "hypothalamic-pituitary-adrenal" (HPA) axis. The researchers analyzed adrenal tissue from 121 human fetuses (following ethical approval from their research ethics committee...Depressed monkeys may help scientists understand human depression
...sed, including low activity levels, disruptions in hormones and higher heart rates. "Even though women are twice as likely as men to experience clinical depression and are at increased risk for depression during premenstrual, postpartum and perimenopausal times in their lives, we have never had any female an...Fat cells around coronary arteries may play a role in heart disease
...ly, releasing potent pro-inflammatory proteins and hormones that regulate inflammation, blood pressure, insulin activity, and other biological processes. Where fat cells are located has a major influence on their impact, as seen in the fact that visceral fat surrounding the internal organs ("apple" body shap...Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
... mice. Illumination of the neural pathway used by hormones to regulate appetite and eating behavior could eve...but scientists have not fully understand how these hormones interact with the brain circuitry. Neurotransmitters in the hypothalamus, including GABA (gamma amin...Hormone use linked to increased breast cancer risk among black women
...because fat tissue produces estrogen, so the extra hormones added by taking pills may not have as much of an effect on estrogen levels in heavier women. "These results based on data from U.S. black women strengthen the evidence that use of estrogen alone and estrogen with progestin increases the risk of breas...Postmenopausal hormone therapy appears to increase risk of blood clots in veins
... plus progestin and found that this combination of hormones appeared to increase the risk of VT. J. David Curb, M.D., University of Hawaii and Pacific Health Research Institute, Honolulu, and colleagues analyzed data from the other WHI trial, in which the effect of estrogen alone was studied in 10,739 women ...Shock wave therapy for kidney stones linked to increased risk of diabetes, hypertension
...se to the kidneys and could alter the secretion of hormones centered in the kidneys like renin, which influence blood pressure. Drs. Krambeck and Joseph Segura, M.D., Mayo Clinic urologist and study investigator, say that they continue to use shock wave treatment, among other alternative treatments for kidne...WHI updated analysis: No increased risk of breast cancer with estrogen-alone
...cancer and because, overall, risks from use of the hormones outweighed the benefits. The combination therapy i...prior to the study and about 13 percent were using hormones at the time they enrolled, but they had to be off of hormones for at least 3 months prior to startin...New research finds direct link between high cholesterol and prostate cancer
...cian at the same institute, explained: "Androgens hormones that have a role in prostate tissue and cancer are synthesised from cholesterol, suggesting a possible biological relationship between high cholesterol and prostate cancer. Gallstones are related to high cholesterol levels as well and are often comp...No link between estrogen-only therapy, breast cancer in postmenopausal women
...le of information about the pros and cons of using hormones to relieve the symptoms of menopause, but a new analysis of data generated by the Women's Health Initiative confirms that one cause of concern can be laid to rest: There is no evidence that taking estrogen alone increases the risk of breast cancer in...New research links metabolism and appetite suppression, opening door to obesity treatments
...earch has focused on the regulation of appetite by hormones such as leptin. Research led by Dr. Greg Steinberg... pathways to those stimulated by exercise. "While hormones such as leptin were initially thought to be the cure-all for weight loss, they were later found to b...American Academy of Neurology 58th Annual Meeting scientific highlights
...e ability than those with the highest levels. Sex hormones may also play a role in the risk for cognitive decline. In a study of almost 800 men and women, those women with the lowest levels of estradiol (a type of estrogen) declined fastest, compared to those women with the highest levels. This correlation w...Study in Science holds promise for a new approach to drug therapy
...on and off as they react to the nutrients, toxins, hormones and even the light particles they are exposed to. GPCRs are a key part of such signaling cascades, passing on messages that make vision possible, carry nerve messages, enable white blood cells to attack infection and set the timing of the heartbeat. ...Younger women appear to be at increased risk for depression after heart attack
...d after heart attack, but the authors suggest that hormones and social pressures may contribute to their increased risk. "Differential sex roles and exposure to social and environmental stressors, such as poverty, lower level of education, responsibilities both at work and home, single parenthood and caring ...Italian researchers find fenretinide cuts the risk of second breast cancers in young women
... may enhance the protective or damaging effects of hormones in different ways according to the stage of breast gland development in women. Said Dr Decensi: "Its differential effect recalls the effect of first full term pregnancy on breast cancer risk, which is protective at a young age and deleterious at an o...Long-term estrogen therapy linked to breast cancer risk
...sked by questionnaire every two years if they used hormones and whether they had developed breast cancer. For...cers developed, 226 among women who had never used hormones and 708 among women who were using estrogen at the time. The longer a woman used estrogen, the high...International Congress of Neuroendocrinology in Pittsburgh June 19-22
... good night's sleep are all determined by various hormones and their interactions with the brain. Indeed, the...nd mood. Research suggests the activity of certain hormones may even decide our longevity. These and other topics related to the neuroendocrine system and its r...Study: Exercise, diet may protect against colorectal cancer
...-like growth factor-1 (IGF-1) and corticosterone - hormones associated with the onset of cancer - but saw no correlation with a greater numbers of polyps. Colbert explains, "These data suggest that voluntary exercise that induces a negative energy balance protects against the onset of cancer in these mice, b...Worsening anemia signals poorer outcomes in men treated for advanced prostate cancer
...beyond the gland. It blocks the production of male hormones that can promote prostate cancer growth. This comm...t for advanced prostate cancer wipes out most male hormones found in the body. It also is known to reduce red cell production, making anemia one of its adverse ......at after just a few days of sleep restriction, the hormones that control appetite cause people to become hungrier, so we thought that women who slept less might eat more. But in fact they ate less," Dr. Patel said. "That suggests that appetite and diet are not accounting for the weight gain in women who sleep...