Penn researchers discover novel pathway for increasing 'good' cholesterol
...stroke. Although this study was performed in mice, humans have the same proprotein convertases and endothelial lipase, and these enzymes are conserved in all vertebrates. Jin and Rader expect that the same pathway for controlling HDL-C will apply to humans. The next step is to study how the genes for th...Green tea holds promise as new treatment for inflammatory skin diseases
...ic way to regulate them. We need further study on humans to determine the full effects. ...Takeda responds to the FDA advisory committee recommendation
...oth prospective and observational, studies in both humans and animals, all have shown no evidence that ACTOS is associated with an increased risk of heart attack or stroke, said Mehmood Khan, M.D., TGRD president. Critical in this body of data is the PROactive (PROspective PioglitAzone Clinical Trial In Mac...Barrow scientists make headlines for their research on fixational eye movements
...ing most of our visual experience and without them humans would become blind to stationary objects. We are thrilled to have our research highlighted in Scientific American, says Dr. Martinez-Conde. Fixational eye movements have long been debated and our research has proven that they do serve a very impor...Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
...ount of ZMPSTE24. Genetic defects in ZMPSTE24 in humans lead to an accumulation of prelamin A and cause a ...cal side effects of the HIV protease inhibitors in humans taking these medications. Ultimately, we would like to further explore why some HIV protease inhib...Taking animals out of laboratory research
... forward which take account of the welfare of both humans and animals, without jeopardising the ground-breaking work on the major healthcare challenges of the 21st century taking place at research centres around the world. The official opening of the new FRAME Alternatives Laboratory will be performed by ...Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
...s will generate better data on the potential risks humans face from environmental agents, building a stronger scientific foundation that can improve regulatory decisions to mitigate those risks, and reducing the time, money, and animals needed for testing. Implementing the strategy envisioned by the com...Avian influenza on people's minds
... many are unaware that there have been no cases in humans or animals in the United States. Despite this, A... the avian influenza virus is not transmissible to humans from eating fully cooked chicken or eggs. The methods for destroying avian influenza during the c...UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
... leukemia in vitro, clinical application of CPT in humans has only been carried out with CPT derivatives that have improved water solubility. In order to be used on humans, current cancer therapies such as CPT or Taxol, which are poorly water soluble, must be mixed with organic solvents in order to be ...Low-carb diets' effects linked to rise in newly identified 'starvation hormone'
...h the physiological effects of a ketogenic diet in humans mimic those seen in mice remains to be determined,...lier added. She intends to examine FGF21 levels in humans after a few days on the Atkins diet, she said. Either way, such low-carb, high-fat diets arent lik...Low doses of ecstasy associated with decline in verbal memory
...round information in the article. Research in both humans and animals suggests that the drug can harm the brain. Ecstasy may damage nerve cells that respond to the hormone serotonin, which is involved in mood, thinking, learning and memory. Thelma Schilt, M.Sc., of the Academic Medical Center of the Unive...Blocking stress protein decreases Alzheimer's peptide in mice
...gs of the National Academy of Sciences. Studies of humans and animals have suggested that stress may increase risk of Alzheimer's disease, but the new research is among the first studies to elaborate the basic biomolecular mechanisms that may underlie this increased risk. The results build on earlier findin...International journal group updates guidelines on registration of clinical trials
...spectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. The ICMJE will not consider results posted in the same clinical trials registry in which the primary registration resides to be previous publication if the re...Flaxseed stunts the growth of prostate tumors
...cerous. "Our previous studies in animals and in humans had shown a correlation between flaxseed supplementation and slowed tumor growth, but the participants in those studies had taken flaxseed in conjunction with a low-fat diet," said Wendy Demark-Wahnefried, Ph.D., a researcher in Duke's School of Nurs...Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
...ice, a result that helps to relate the findings to humans with increased risk of vascular disease. Next, Dr. Scalia says, they would like to better understand how adiponectin prevents the increase in white blood cell-blood vessel "anchoring" molecules in disease conditions. The group is also testing t...Mouse model points to possible new strategy for treating rare muscle disease, kidney disorders
...th respect to the disease HIBM, we are hoping that humans with the same genetic mutation as in our mouse model will also respond to ManNAc. The availability of these transgenic mice will assist us greatly in assessing the appropriate dosage of the drug to test in HIBM patients. To date, none of the offspr......ont be possible to tell without careful studies of humans whether NDGA is beneficial, useless, or harmful to people. Occasionally, something that is harmless in mice turns out to be highly toxic for people, Miller cautions, adding that the Food and Drug Administration doesnt evaluate the safety of such her...Human stem cell treatment restores motor function in paralyzed rats
...al models, and hopes to move to clinical trials in humans by next year. Paraplegia from spinal cord ischemia is a serious complication that occurs in 20 to 40 percent of patients undergoing a surgical process called aortic cross-clamping. When the surgeon works on the aorta, a major blood vessel, to c...Scripps Research awarded $17 million for adult stem cell use to treat eye diseases
...ured many mice, but whether it will work or not in humans is another story-but thats what we want to find out. This is an extraordinary opportunity to take highly novel laboratory concepts, test them experimentally, and translate them into therapies for the treatment of blinding eye disease."...Texas aging meeting to feature NIA Interventions Testing Program 1st report
...ion on the CALERIE Study of caloric restriction in humans (calorie restriction is the only method proven thus far to extend life in rodents) and a report on life span expansion by resveratrol, a compound found in red grapes. "This conference will showcase the hottest areas of research in aging, and we are...