Penn study finds pro-death proteins required to regulate healthy immune function
... online in the journal Immunity, bolster the teams hypothesis that metabolic cell activity directly controls life and death decisions in cells. This issue also includes a related commentary by the studys lead author, Russell Jones, PhD, and senior author Craig B. Thompson, MD. It is well known that cells that...Stanford researchers find culprit in aging muscles that heal poorly
... discovered that klotho inhibits Wnt activity. The hypothesis is that klotho production declines with age, and thus its effectiveness against Wnt decreases, allowing Wnt activity to pick up and disrupt the normal signaling to the stem cells in a variety of tissues studied. Rando said that, although the work o...Shining light on pancreatic cancer
...s with colon cancer and support the "field effect" hypothesis that suggests initial cancer stages, even pre-cancerous lesions, can cause minute, potentially detectable changes throughout an entire organ. If similar results are found in other organs, the effect could have broad impact in the timely treatment of ...Children and young people show elevated leukaemia rates near nuclear facilities
...nlen from Oxford University has also put forward a hypothesis that viral transmission, caused by mixing populations in a new rural location, could be responsible. It is clear that further research is needed into this important subject....Patients with soft tissue sarcomas should be treated at high volume centers
...rida, the Juan Gutierrez and colleagues tested the hypothesis that soft tissue sarcomas are better treated at institutions with higher volumes of cases. They used the Florida cancer data system, a prospective database of all cancer cases in the state of Florida since 1981, to identify all records of soft tissue...UCLA, Italian chemists move closer to solving Lou Gehrig's disease mystery
...ot be there at all. They present evidence for this hypothesis in new research published in Proceedings of the Na...ne, Valentine said. It was such a puzzle, but this hypothesis can solve it. If scientists can figure out why ALS patients lack the copper and zinc, that would b...Spuds that like you -- in your summer salad
...the peripheral blood to the gut, which support the hypothesis of IBS being at least partially an inflammatory disorder. She says the decrease in lymphocytes observed by the Spanish is therefore interesting, and a diet of resistant starch may be worth trying in IBS patients....Brightening prospects of using fluorescent nanotubes in medical applications
...uld make them easy to locate. At least that is the hypothesis the researchers hope to test....Folic acid supplements do not appear to reduce risk of colorectal tumors
... folic acid promoted growth of these lesions. This hypothesis is consistent with experimental studies showing increased colorectal neoplasia when folic acid is administered after lesions are present." "Nonetheless, by the nature of the design, the results do not provide information on primary prevention by fo...Exercise lowers insulin in breast cancer survivors
..., and her colleagues research findings support the hypothesis that exercise lowers levels of the hormone insulin in the bloodstream. Studies have found an association between relatively high levels of insulin often seen in obese and sedentary people and an increased risk of breast cancer recurrence and breast...Shark cartilage shows no benefit as a therapeutic agent for lung cancer
...es analyzing cartilage extracts have supported the hypothesis that cartilage contains inhibitors of angiogenesis. Also, shark cartilage has long intrigued the public due to the belief that the incidence of cancer in this cartilaginous fish is very rare. Early Phase I and II studies in lung and renal cancers sug...Dasatinib shows high early response rate as first treatment for chronic myelogenous leukemia
...rms BCR-ABL while imatinib blocks only one. "Our hypothesis is that treating with dasatinib first will produce an earlier response, which may translate to a better overall survival," Atallah says. "We haven't proved that here, but these early results are encouraging." Atallah and colleagues evaluated 35 pat...OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
...ct fuel cancer progression. To the extent that our hypothesis proves true, C-reactive protein may be reflecting the overall intensity of the inflammation," Beer said. The finding that higher CRP is associated with shorter survival and a lower probability of response to chemotherapy is a result of a secondary...Research shows aerobic exercise helps maintain muscle in elderly
...rate of muscle loss in aging. We need to test this hypothesis further with larger trials, but still, it's one more reason why elderly people ought to be regularly walking, swimming or cycling." ...Detecting cold, feeling pain: Study reveals why menthol feels fresh
.... In the current study, the team confirmed their hypothesis by "knocking out" the gene that synthesizes the receptor, both in sensory neurons in cell culture and in mice. The cells in culture were unresponsive to cooling agents, including menthol. The genetically engineered mice did not discriminate between w...Brain activity reflects differences in types of anxiety
...t whether neural activation patterns supported the hypothesis that these two categories of anxiety are distinct, the researchers selected 42 subjects from a pool of 1,099 undergraduate college students, using psychological tests to categorize them as "high anxious apprehension," "high anxious arousal," or neith...Researchers find deadly prescription drug effects 6 years before FDA
...action, outcomes and treatment or prevention. Our hypothesis is that the quality, not the quantity counts, Bennett said. A small number of very good case reports is better than a large number of very bad case reports. Bennett leaped into pharmacovigilance -- as the field is called -- when a bad drug reactio...Aggressive treatment for whiplash does not promote faster recovery
... under a no-fault insurance scheme and support the hypothesis that the prognosis of whiplash injuries is influenced by the type and intensity of care received within the first month after injury," the authors state. They note that effective care, if medically needed, improves the prognosis of patients and tha...Persistent smokers may have higher risk to become depressed than never smokers
...ve a role in the etiology of depression. The third hypothesis suggests that there is a reciprocal mechanism between smoking and depression. The fourth hypothesis says that there are shared underlying genetic factors explaining this co-morbidity. This study co...Study finds 'wake up and breathe' strategy allows patients to come off ventilator sooner
...m turning off the ventilator. Our study proved our hypothesis that if we connect these two processes, it will safely allow patients to come off the ventilator earlier. ...