Variant prion protein causes infection but no symptoms
...ch? What if only small clumps are toxic?" If this hypothesis proves correct, Dr. Chesebro says, the ongoing research could eventually alter scientists' views on preventing prion diseases, shifting emphasis away from stopping the production of prion protein clumps and toward preventing interactions with prion p...Treating autism 'right the first time'
...advanced psychology students who were blind to the hypothesis of the study. After five weeks, PRT treatment was stopped for the non-responders because they failed to show any improvement, and it was ethically indefensible to continue. They were referred to other programs. (The non-responders' slightly higher c...Immune factor GM-CSF significantly improves Crohn's disease symptoms
...of Crohn's." Korzenik has been investigating this hypothesis for several years, in collaboration with Brian Die...curring. Korzenik and Dieckgraefe developed their hypothesis based on studies of certain genetic disorders known to affect the innate immune system. Because som...Bad metabolism in blood vessels linked to high blood pressure and atherosclerosis
...osclerosis and high blood pressure. "Our original hypothesis was wrong," says Semenkovich, who directs the School of Medicine's Division of Endocrinology, Metabolism and Lipid Research and is a staff physician at Barnes-Jewish Hospital. "When we made mice that produced uncoupling protein in the aorta, we were ...High blood pressure causes pathological scars in the heart
...umber of clinical and basic research groups to the hypothesis that not everything was quite right with the idea ...s and high blood pressure human patients that this hypothesis was, indeed, correct and proceeded to explore some possible mechanisms for this deterioration. Rese...Birth weight and breastfeeding in infancy may affect premenopausal breast cancer risk
...or postmenopausal women. "Our results support the hypothesis that early life events impact women's breast-cancer risk later in life," said Barba. "Further research based on targeted studies is needed to reach a deeper understanding of the underlying biological mechanisms."...Trumpeting vaccination may only entrench opposition
...Before" surveys confirmed the researchers' initial hypothesis these participants were generally non-supportive of vaccines with only nine per cent saying they would recommend the polio vaccine and six per cent saying they would recommend the MMR (measles, mumps and rubella) vaccine. However, analysis of the "...Neuroimaging confirms the greater vulnerability of women's brains to alcohol
...omen. The findings support and build upon a prior hypothesis that women develop alcohol-related brain damage more readily than men. "Studies using brain-imaging techniques are time-consuming and expensive," said Karl Mann, full professor in the department for addictive behavior and addiction medicine at the U...MMR vaccine does not increase risk of Crohn's disease
...n programme, providing strong evidence against the hypothesis that MMR vaccine increases the risk of Crohn's disease....Atorvastatin shows promise in small trial for the treatment of mild to moderate Alzheimer's disease
...tend to support the trial's rationale based on the hypothesis that excess brain cholesterol-promoting amyloid beta production [excess amyloid beta protein deposits are a hallmark of AD] and subsequently the symptoms of AD come from the blood because of increased circulating levels." "Finally, although the resul...Two studies offer clues about how alcoholic behavior is 'switched' on
...ight reduce alcohol consumption. They tested their hypothesis in rats with a genetic predisposition to prefer alcohol when given a choice between a 10 percent ethanol solution and pure water, comparing them with rats that had no prior preference for alcohol. Both sets of animals were treated with varying doses ...A candidate biomarker to improve treatment of lupus patients
...d Mary K. Crow, M.D., the team set out to test the hypothesis that activation of a particular interferon pathway-- the type I interferon pathway--is more common among SLE patients with the highest disease activity. Activation of this pathway is indicated by high levels of expression of interferon-inducible gen...American Thoracic Society journal news tips for May 2005 (first issue)
...ith those of prior investigators, they support the hypothesis that acetaminophen use can cause an increase in asthma risk with potential effects on the onset, progression, and severity of the disease. FAMILY MEMBERS OF ICU PATIENTS SHOWRISK OF POST-TRAUMATIC STRESS SYNDROME In a study of 284 family members of...Breast-cancer risk linked to exposure to traffic emissions at menarche, first birth
...opment," said Nie. "Our study findings support the hypothesis that exposures in early life contribute to breast-cancer risk." The study was based on data from the Western New York Exposures and Breast Cancer (WEB) study. All participants were women between the ages of 35 and 79 who lived in Erie or Niagara co...Researchers identify marker of heart disease in low-birthweight babies
...e plaque can rupture, causing a heart attack. "Our hypothesis is that infants with elevated apo C-1 levels at birth will have higher apo C-1 levels in childhood and adulthood" Kwiterovich said. "Many people associate HDL as being the 'good' cholesterol, and indeed, higher levels of HDL in general are, in adult...Liver may be source of 'good' cholesterol
...ause of high levels of ABCA1 there. To test their hypothesis and learn more about how HDL is produced, the researchers developed mice without the ABCA1 gene in the liver which means their livers cannot produce HDL. The researchers measured HDL levels in these mice and found that concentrations of HDL were 80 ...Scientists to study actions of botanical oils
...n blood vessels. A second project will explore the hypothesis that a rare oil found in nature known as echium reduces atherosclerosis by lowering triglycerides. Project 3 examines how borage, marine (fish) and echium oils reduce inflammatory messengers that cause diseases such as asthma and arthritis. A fourth...Children's hospital neurologist receives Young Investigator Award in spinal muscular atrophy
...uidance. His research will continue to examine the hypothesis that the protein SMN (produced by the SMN1 gene) may play a role in the transport or translational regulation of ribonucleic acids (RNA) necessary for axon growth or guidance in motor neurons. To evaluate this hypothesis, he will test whether SMN is ...Study examines effectiveness of anti-anemia drug in treatment of cancer patients
...onse and improve survival, but trials testing this hypothesis have had conflicting results. To determine the association between erythropoietin treatment and hematologic response, blood transfusions, adverse events, and overall survival, Andreas Engert, M.D., of the University of Cologne in Germany, and colleag...