Genetic markers in surrounding tissues linked to breast cancer tumor grade, presence of metastases
...ne Institute, Cleveland, and colleagues tested the hypothesis that cell genomic alterations in tumor stroma (the cells and tissues surrounding the tumor) significantly alter tumor behavior, as reflected in clinicopathological features at the time of diagnosis. The researchers conducted a cross-sectional analysi...Weill Cornell researchers use 'Virtual Iraq' simulation to study post-traumatic stress disorder
...ent treatments." The researchers are testing the hypothesis that verbalizing the traumatic experience, instead of suppressing it, enables patients to better integrate the experience into regular conscious memory, in turn, making the triggering of intrusive traumatic memories (and other re-experiencing symptom...Coenzyme Q10 does not improve Parkinson's disease symptoms
...arkinson's disease, our study does not support the hypothesis that restoring the impaired energy metabolism of the diseased dopaminergic neurons leads to symptomatic benefits in Parkinson's disease," the authors conclude. "Future studies will need to explore the protective effects of CoQ10 at the highest effect...Breakdown of myelin implicated in Alzheimer's, UCLA research shows
...n turn destroy more myelin. Bartzokis tested his hypothesis by examining published images of amyloid deposition acquired in living individuals; the images were made using radiolabeled ligands, molecules that bind to amyloid plaques in the brains of Alzheimer's patients. Next, he compared the physical location...No evidence older women generate new eggs
...hina, say they can find no evidence to support his hypothesis that women may generate new eggs after birth. The USF researchers searched for markers of stem cells or of meiotic cell division in ovarian cells biopsied from 12 women between the ages of 28 and 53. "Despite using the most sensitive methods av...Hepatitis C increases risk of non-Hodgkin lymphoma
...conducted a retrospective cohort study to test the hypothesis that HCV infection is associated with increased risk for malignancies of the blood and blood-forming tissues, related disorders, and thyroid cancer. The study involved patients from U.S. Veterans Affairs health care facilities from 1997-2004 and inc...New research disproves belief that group psychotherapy extends the lives of cancer patients
...g the fact that they were not designed to test the hypothesis that psychotherapy extends the lives of cancer pat...d not be considered warranted for cases in which a hypothesis was interesting but improbable given the available data. Therefore, the authors conclude that there...Brains scans of symptomatic Gulf War veterans show differences
...differences in the veterans brain volumes, but the hypothesis is that they are related to exposure to hazardous substances during the first Gulf War," said study author Roberta White, PhD, of Boston University School of Public Health. "Many troops were exposed to hazardous substances such as pesticides, and oth...Other highlights in the May 2 JNCI
...days after treatment. "These results support the hypothesis that acquired resistance to the individual agents is the result of [an] incomplete blockade of this complex network at the receptor level and not activation of a different survival pathway," the authors write. Contact: Kimberlee Barbour, kbarbour...Mayo Clinic research in cardiovascular disease presented at Experimental Biology 2007
...ication," Kraemer says. Researchers tested their hypothesis by inoculating animal models with nanoparticles from human calcified tissues. A second group of models received a diluted inoculation. Blocked arteries were apparent in some animals in both groups 35 days after receiving the dosage. This study was ...Study finds role of mid-brain in integrating heart and respiratory response to exercise
...: Methodology The researchers set out to test the hypothesis that neural activity in subcortical structures recorded from humans who have deep brain stimulating electrodes chronically implanted is directly related to changes in heart rate (HR), arterial blood pressure (ABP) and pulmonary ventilation (VE) when ...Depression among retired NFL players: Rates mirror the general public, but pain compounds symptoms
... Schwenk says. Future studies should explore the hypothesis that the physical disabilities and chronic pain experienced by retired players cause significant difficulty with maintaining their fitness levels, making them more at risk for depression, the authors say. ...Commonly used pain medications do not prevent Alzheimer's disease
... "Although our study was conducted to test the hypothesis that celecoxib or naproxen would reduce the incidence of Alzheimer's disease, these results indicate no such effect, at least within the first few years after treatment begins," said study author Constantine Lyketsos, MD, MHS, with Johns Hopkins Bayv...Study reports changing to a low-fat diet can induce stress
...c, biochemical, and molecular analyses support the hypothesis that preferred diets act as natural rewards and th...hors continue, "These results strongly support the hypothesis that an elevated emotional state produced after preferred-diet reduction provides sufficient drive t...Health-care inequities underscore racial disparities in prostate cancer
...oral factors play an important role. One promising hypothesis is that a lack of knowledge about prostate cancer and preventive care leads to less screening, delayed diagnosis and advanced disease. Led by James A. Talcott, M.D., S.M. of the Massachusetts General Hospital and Harvard Medical School in Boston in...Study questions 'cancer stem cell' hypothesis in breast cancer
... Dana-Farber Cancer Institute study challenges the hypothesis that "cancer stem cells" a small number of self-r...mor questions the validity of the cancer stem cell hypothesis in breast cancer, and suggests clonal evolution involving intra-tumoral heterogeneity as an alternat...Use of common pain relievers associated with increased risk of blood pressure in men
... lining. "These data add further support to the hypothesis that non-narcotic analgesics independently elevate the risk of hypertension," the authors write. "Given their common consumption and the high prevalence of hypertension, our results may have substantial public health implications and suggest that th...Is most published research really false?
...rchers in their never-ending pursuit of scientific hypothesis generation and testing." Nevertheless, they acknowledge that "more methodologic work is needed to assess and interpret cumulative evidence of research findings and their biological plausibility," particularly in the exploding field of genetic associ...Growth factors given with chemotherapy associated with increased risk of blood diseases
...retrospective studies, thus has to be qualified as hypothesis generating rather than conclusive."...