Drug-eluting stent controversy explored in the American Heart Hospital Journal
...trix used for the delivery of drugs, which clearly induces inflammatory responses, may, in part, be responsible for very late thrombosis. Dr. Renu Virmani and colleagues at the CVPath Institute of Gaithersburg, Maryland base the judgments in their article on the evidence obtained through pathologic studies...Low-carb diets' effects linked to rise in newly identified 'starvation hormone'
...ts a high-fat, low-carbohydrate ("ketogenic") diet induces lipid oxidation associated with weight loss, according to Maratos-Flier. Yet the underlying mechanism responsible for the profound physiological changes that the diets induced wasnt fully understood. In the new study, Maratos-Fliers team examined c...Study tests oral insulin to prevent type 1 diabetes
...k that introducing insulin via the digestive tract induces tolerance, a quieting of the immune system. First- and second-degree relatives of people with type 1 diabetes who may be at risk are initially being screened through TrialNets natural history study, which is examining the immune and metabolic event...Limiting stroke damage is focus of study
...ssue and pump revival quickly heals old spines and induces new ones. Now he wants to know if the new spines function and last and if this adaptive recovery also occurs when stroke is the culprit....Researchers investigate impact of lifestyle on GI health
...etite, as absorption of fat in the small intestine induces the feeling of being full and slows down gastric emptying. The aim of this study was to investigate whether a fatty soup consumed before a meal might reduce food intake in both lean and obese subjects and whether this possible inhibitory effect woul...The quest for an effective HIV vaccine presents new possibilities, challenges
...give high priority to creating an HIV vaccine that induces broadly neutralizing antibodies, which might prevent the establishment of HIV infection. Although rare, such antibodies do exist, giving hope to scientists that a vaccine to induce such antibodies can be designed. Drs. Johnston and Fauci conclude ...Drug used to prevent HIV transmission from mother to child damages DNA
...he growing body of evidence that ZDV [AZT] readily induces genetic damage," The authors conclude by emphasizing that they do not advocate eliminating the use of AZT in the treatment of HIV because it is highly effective in preventing mother to child transmission of the virus. However they recommend long-term...Therapeutic unshackles p53 and causes tumor regression
...ion, Pivi Ojala and colleagues show that Nutlin-3a induces human PEL cell lines to undergo cell death by a process known as apoptosis. Nutlin-3a was found to disrupt an interaction between the KSHV protein LANA and the human proteins p53 and MDM2, releasing p53 to mediate apoptosis. As treatment with Nutlin-...New insights into autoimmunity and depression
...ucidating the mechanisms by which anti-ribosomal P induces behavioral changes may lead to novel therapeutic advances for SLE patients with depression," Dr. Shoenfeld reflects....CRP liver protein induces hypertension, UT Southwestern researchers have found
... a marker of the risk of hypertension, it actually induces hypertension," said Dr. Wanpen Vongpatanasin, associate professor of internal medicine and lead author of the study appearing in the February issue of Circulation . UT Southwestern researchers studied mice with an engineered gene for CRP that was...Common anesthetic may induce cell death, generation of Alzheimer's-associated protein
...ults define molecular pathways by which isoflurane induces deposition of A-beta, both directly and via caspase activation, and by which A-beta deposits lead to further caspase activation and apoptosis. "Even though our findings and those from other studies suggest that isoflurane may affect Alzheimer's pat...Study tests oral insulin to prevent type 1 diabetes
...k that introducing insulin via the digestive tract induces tolerance, or a quieting of the immune system. Insulin taken orally has no side effects because the digestive system breaks it down quickly. To lower blood glucose, insulin must be injected or administered by an insulin pump. In type 1 diabetes, ...Natural protein stops deadly human brain cancer in mice
...n cancers in mice using a protein that selectively induces positive changes in the activity of cells that behave like cancer stem cells. The report is published this week in Nature. The most common type of brain cancer-glioblastoma-is marked by the presence of these stem-cell-like brain cells, which, instea...Pro-vitamin E shown to be active against breast cancer cells
...diseases such as colon cancer and mesothelioma. It induces controlled cell death or apoptosis in tumour cells." Transgenic mice with high HER2 breast cancers were treated over a three week period and tumour size was monitored every three days by ultrasound imaging. The high resolution ultrasound allows...'Tribbles' protein implicated in common and aggressive form of leukemia
...o AML. Overall, the findings suggest that Tribbles induces AML by inactivating the C/EBP protein. The results were published in this week's issue of Cancer Cell. AML is a malignancy that arises in white blood cells and develops when there is a defect in immature immune cells in the bone marrow. In AML, th...Use, as well as 'meth mouth,' on the rise
...ant, meth can cause increased motor activity which induces excessive chewing, tooth grinding or clenching, furthering the oral problems associated with the drug use. Management of meth mouth: Identify the problem and seek professional assistance for the substance abuse Patients should avoid diuretic...Encouraging results in pancreatic cancer research
...owth. The researchers previously found that PNC-28 induces death of a variety of human tumor cell lines, including a pancreatic cancer cell line, while not harming healthy cells. The research team has now given PNC-28 to laboratory animals to test its ability to block the growth of pancreatic cancer cells....New studies in the journal Sleep focus on helping children, women sleep better
...wake cycle. Light deprivation, on the other hand, induces a loss of noradrenergic fibers which, in turn, throws a person's sleep-wake rhythm out of kilter. The study, conducted by Mnica McGonzlez, PhD, and Gary Aston-Jones, PhD, of the University of Pennsylvania, Philadelphia, focused on rats, that were m...Elevated testosterone kills nerve cells
...one for relatively short periods, six to 12 hours, induces a decrease in cell viability by activation of a cell death program," Ehrlich said. "Low concentrations of testosterone had no effects on cell viability, whereas at high concentrations the cell viability decreased with incremental increases in hormone...First evidence that musical training affects brain development in young children
...training in auditory, sensory and motor activities induces changes in the cortex of the brain.Brain activity was measured by magnetoencephalography (MEG) while the children listened to two types of sounds: a violin tone and a white noise burst. MEG is a non-invasive brain scanning technology that measures t...