The role of Type II Collagen in rheumatoid arthritis
...ilage and bone. The agents of destruction include inflammatory cells, cytokines, and protein-degrading enzymes kn...proteinases (MMPs). The vicious cycle begins when inflammatory cells infiltrate the tissue lining the joints and consume excess oxygen. In addition to unleashing ...Pain and its impact on the treatment of rheumatic disease
...y in a state of change. But neurotransmitters and inflammatory molecules make rheumatic pain feel chronic. Rheum...a rheumatic patient's production of pain-provoking inflammatory agents. How can a rheumatologist accurately assess a patient's pain? As Dr. Fitzcharles acknowledg...Sydney researchers explain how stress can make you sick
...une responses getting out of control as in various inflammatory and autoimmune diseases such as Crohn's disease, rheumatoid arthritis, multiple sclerosis, type I diabetes and lupus....Inflammation linked to chronic pain: Study
...d author of the study. "We believe that the body's inflammatory response helps to etch the initial pain into our memory." Normally when a mouse or a person experiences a painful event, receptors in the injury site send an electrical impulse up the spine and to the brain. The signal triggers receptors called glut...JCI table of contents: December 8, 2005
...ed to have beneficial effects on the metabolic and inflammatory effects caused by a high-fat diet. TITLE: CCR2 modulates inflammatory and metabolic effects of high-fat feeding AUTHOR CONTACT: Anthony Ferrante Jr. Naomi Berrie Diabe...Australians of the year forge partnership for burns drug development
...damage in these types of diseases is caused by the inflammatory reaction," Professor Stanley said. "These Phylomers appear to be very effective molecules in blocking this secondary damage that does so much harm."...Immunosuppressive drug appears effective in reducing new brain lesions in MS patients
...(MS) appears to be effective in reducing new brain inflammatory lesions and is well tolerated, according to a stud...cts on the frequency and accumulation of new brain inflammatory lesions has not been studied in MS, according to background information in the article. MS is a dis...News briefs from the journal Chest, December 2005
...up). Every three months, dyspnea scores, levels of inflammatory mediators, and exercise capacity were recorded. Ov...s and exercise capacity significantly improved and inflammatory mediators significantly decreased for patients in the treatment group, while there was no significan...News tips from The Journal of Neuroscience
...5α-reduced neurosteroids (5αNS) modulate inflammatory pain in the rat spinal cord. The authors found tha...sufficient to alter basal synaptic inhibition. The inflammatory stimulus increased sensitivities to thermal and mechanical stimuli, but FIN delivery before inflamma...Carbon monoxide soothes inflammatory bowel disease
...n that smokers rarely suffer from a common form of inflammatory bowel disease (IBD) called ulcerative colitis, but they didn't know why. A new study in the December 19 issue of The Journal of Experimental Medicine might help explain this apparent resistance. Scott Plevy and his colleagues at the University of P...Air pollution, high-fat diet cause atherosclerosis in laboratory mice
... "We noted a significant increase in the number of inflammatory cells and enzymes in the arteries of the mice exposed to air particles," said Rajagopalan. In addition, the fine particles had a measurable effect on the ability of the arteries to dilate, an important indicator of artery wall function. "We found tha...Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe
...ion once thought to be wholly independent of other inflammatory systems has now been linked to another major path...or drugs such as Vioxx. Until now, these two major inflammatory mechanisms were assumed to be unrelated and independent of each other, the researchers say. "The f...Jefferson scientists discover mechanism tying obesity to Alzheimer's disease
...iated with heart disease and diabetes, such as the inflammatory marker C-reactive protein, insulin, and high density lipoprotein in 18 healthy adults who were either extremely overweight or obese. They found a "statistically significant correlation" between body mass index and beta-amyloid. "Ours is one of the fi...Promising new treatment for ulcerative colitis sufferers
...ve colitis patients. A drug already used for other inflammatory diseases, including Crohn's and rheumatoid arthritis, has received FDA approval for treatment of ulcerative colitis after performing well in clinical trials. UK was a primary investigator of infliximab, brand name Remicade, and enrolled the largest s...New evidence to support combination therapy for achieving remission of early rheumatoid arthritis
A chronic and potentially crippling inflammatory disorder, rheumatoid arthritis (RA) progressively wears away the cartilage and bone. Joint erosions are routinely seen within 6 months of RA's onset, and occur more rapidly earlier in the course of the disease. Moderate disability within 2 years of...The impact of smoking and genes on rheumatoid arthritis
...n healthy individuals and relatively rare in other inflammatory conditions, citrulline-modified proteins are common in about two-thirds of RA patients and may be an underlying factor in the development of the disease. To investigate whether smoking and SE genes trigger immune reactions to citrullinated proteins,...Study sheds new light on causes of common STD
...bly, Chlamydia trachomatis) and may lead to pelvic inflammatory disease, infertility, and chronic pelvic pain. Though the cause of NGU is sometimes known, and antibiotics (azithromycin or tetracycline) are generally effective, about half of all cases have no identifiable cause a fact that makes treatment frustra...Doctors at UVA health system search for new treatments for diabetic kidney disease
...rs to test whether certain drugs can interrupt the inflammatory process that occurs in diabetic kidney disease. These drugs act on receptors for the compound adenosine. One drug, called ATL-146e, is licensed to the company Adenosine Therapeutics LLC of Charlottesville, Va. Preliminary results show that this drug...Understanding fatigue in chronic liver disease
...s were found in similar locations to those seen in inflammatory brain disease supports the likelihood that they are linked to pathological effects. However, they note that there are still unresolved issues in understanding sickness behaviors and that it remains unknown whether the results from the animal study wi......triction include kidney failure, type-II diabetes, inflammatory bowel disease and morbid obesity. Overall, Stiehm proposed that new evidence can be found for using certain viruses to treat diseases such as HIV, which do not respond to other medications. "There have been several studies indicating that HIV patie...