Tag: "inhibit" at medical news

Pathway links inflammation, angiogenesis and breast cancer

...IKK or with active IKK and rapamycin injections to inhibit mTOR had mean volumes of less than 100 milimeters. Similar disparate tumor sizes were found when the tumor-suppressing TSC1 was inactivated. Tumors with TSC1 inactivated also were found to have greater blood vessel density - a measure of angiogenesis...

Miniature implanted devices could treat epilepsy, glaucoma

... when stimulated, releases the neurotransmitter to inhibit the seizure. The engineered neurons are living tissue stimulated with a microchip. Rickus and Irazoqui have shown that a certain amount of electrical current causes the neurons to release specific and controllable quantities of neurotransmitter. ...

Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy

... Two commonly used options are anticoagulants that inhibit the clotting process (e.g. warfarin), and drugs such as aspirin that make blood platelets less likely to bind together and trigger a clot. In standard medical practice, anticoagulants are often given to people with AF who are at high risk of stroke...

Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus

...that certain HIV protease inhibitor drugs directly inhibit an enzyme called ZMPSTE24, which is important for generating the structural scaffolding supporting the cell nucleus, said Catherine Coffinier, Ph.D., study author and an assistant researcher at the David Geffen School of Medicine at UCLA. UCLA rese...

Future therapies for stroke may block cell death

...t lead to the death of brain cells. Compounds that inhibit a group of enzymes called histone deacetylases can modulate gene expression, and in some cases produce cellular proteins that are actually neuroprotective -- they are able to block cell death. "For the first time, we show which one of the 11 histon...

Brightening prospects of using fluorescent nanotubes in medical applications

...le of producing light. Metallic nanotubes actually inhibit the brightness of their fluorescent neighbors. But it has been very difficult to separate the strongly fluorescent SWNTs from all the rest in large quantities. Nanotube soot is insoluble in water. So researchers routinely mix it with special soap and...

Tony Hunter receives Robert. J. and Claire Pasarow Award for Cancer Research

...a(r) and Tarceva(r)), as researchers found ways to inhibit the special proteins called tyrosine kinases that are responsible for tyrosine phosphorylation. Phosphorylation - the addition of a tiny phosphate ion to a large protein molecule - is a common way in which the body turns on or off proteins such as...

Tumor cell activity may provide clues for treating breast cancer in young women

...over the age of 45, Anders said. If we are able to inhibit these processes by using drugs -- some of which are already available and being used to treat other cancers -- we might have a better chance at treating these women more effectively and possibly even curing them. Research is currently under way to ...

Agent slows aging in mice

...riments to find out if certain chemicals, known to inhibit inflammation, cancer and other destructive processes, can boost the odds of living longer. Today at the annual meeting of the American Aging Association, University of Michigan scientist Richard A. Miller reports early results from a mouse study hi...

Scripps Research awarded $17 million for adult stem cell use to treat eye diseases

...unately, these treatments often fail to completely inhibit abnormal vascular growth, and may cause tissue injury and even exacerbate the underlying condition. The Friedlander laboratory's approach, however, takes a dramatically different tack-repairing, rather than destroying, blood vessels. "By preservin...

Limiting stroke damage is focus of study

...simulated stroke. He believes by finding a way to inhibit anoxic depolarization in a slice of living brain, he can protect neurons by stopping structural and functional damage and promoting recovery. His previous work has shown that cold also inhibits the sodium-potassium pump, resulting in dendrite beading...

Coffee consumption may lower blood uric acid levels -- the precursor of gout

...e insulin sensitivity. Chlorogenic acid also helps inhibit glucose absorption in the intestine; in another study decaffeinated coffee seemed to delay intestinal absorption of glucose and increase concentrations of glucagon-like peptide 1, which is well known for its beneficial effects on insulin secretion an...

Withdrawn MS drug returns to market

...id organs, such as lymph nodes and the spleen, and inhibit reactivation in the central nervous system. It has been shown to significantly reduce leukocyte cell numbers in spinal fluid, with benefits continuing for six months after treatment. "The release of natalizumab ushers in a new era in the treatment...

COX inhibitors may weaken protective qualities of estrogen hormone therapy

...in women who used NSAIDs, such as ibuprofen, which inhibit COX-1 and COX-2, at the same time as hormone replacement therapy, this protective effect was lost. Whether taking estrogen actually confers cardioprotection remains controversial. It seems likely that benefit is conferred only on women who commenc...

Other highlights in the May 2 JNCI

...an Single Agent Treatment with three drugs that inhibit the human epidermal growth factor receptor (HER) stops HER2-positive breast cancer tumor growth in mice better than treatment with just one or two of the drugs. Grazia Arpino, M.D., Ph.D., of Baylor College of Medicine in Houston, and colleagues m...

Combination treatment stymies breast cancer growth

...perimental drugs gefitinib and pertuzumab -- that inhibit HER-2 in different ways can more completely block the growth signals in the tumor, causing it to die. In one of the tumors studied in this report, blocking the stimulatory effects of estrogen on the tumor was also necessary for optimal treatment, s...

Your brain and hormones may conspire to make you fat

...., will address. The hormones leptin and insulin inhibit the development of obesity when consumption of fat and calories increases. Some people respond very well to these hormones and they dont gain weight during these bouts of overeating. But others are less responsive to leptin and insulin, which makes t...

Green tea compound suppresses factors causing cartilage, bone destruction in arthritis

...that a compound derived from green tea was able to inhibit production of several immune system molecules invo...t anti-inflammatory molecule, and also was able to inhibit production of interleukin-6 (IL-6) and prostaglandin E2, the inflammatory products found in the conn...

Diet and lifestyle -- In the cancer fight, eating well is the best revenge

...attributed to the ability of these constituents to inhibit cell cycle, cell proliferation and oxidative stress, and to induce detoxification enzymes and apoptosis," Nthlings said. Polyp characteristics, diet, lifestyle factors and high-risk colorectal adenoma recurrence in the polyp prevention trial: Ab...

Northwestern chemists develop new method for synthesizing anti-cancer flavonoids

...nd some of the new molecules Karl already has made inhibit the motility of prostate cancer cells -- they stop the cells dead in their tracks," said Bergan, associate professor of hematology and oncology. "It is important for us to understand how these synthetic flavanones work because combination therapies a...

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(Date:8/20/2014)... years, Virginia Tech,s Wu Feng has built upon a ... "Computing in the Cloud" program, and synergistically complemented it ... from the Air Force on "big computing" for mini-drones ... National Institutes of Health on "big data" for the ... computing" aspects from each grant, he was able to ...
(Date:8/20/2014)... DENVER (August 20, 2014) Women who are poor ... to infants with elevated levels of the stress hormone, ... later in life, according to a new research from ... online recently in the American Journal of Human ... infants and relate it directly to the socioeconomic status ...
(Date:8/20/2014)... grows to about 4,000 members, it triggers an important ... a special type of comb used for rearing male ... Department of Neurobiology and Behaviour at Cornell University, led ... of honeybee colonies. The results are published in Springer,s ... , Reproduction isn,t always a honeybee colony,s top ...
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