Penn researchers discover novel pathway for increasing 'good' cholesterol
...tudy how the genes for the PCs, EL itself, and ELs inhibitor are regulated. In addition, Jin and Rader plan to ...fy polymorphisms in the genes for PCs, EL, and its inhibitor that are associated with HDL-C levels, thus supporting that this pathway is relevant in humans, says...Trial stops after stroke and mortality significantly reduced by blood
...uretic(indapamide 1.5mg SR), and an additional ACE inhibitor (perindopril), intablet form once a day. Emeritus Professor Chris Bulpitt, HYVET Principal Investigator from theCare of the Elderly Department at Imperial College London, said: "It wasnot clear prior to our study whether the over-80s would benefit ...New oxidation methods streamline synthesis of important compounds
...atalyst to streamline the synthesis of a peptidase inhibitor drug candidate, a nucleotide-sugar L-galactose, and is currently working on the antibiotic erythromycin A. ...Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
...how, for the first time, that certain HIV protease inhibitor drugs directly inhibit an enzyme called ZMPSTE24, ...hat the inhibition of ZMPSTE24 by the HIV protease inhibitor drugs led to an accumulation of prelamin A, which is a precursor to mature lamin A a key molecule i...Low libido in menopause linked to trouble sleeping
...ing depression with a selective serotonin reuptake inhibitor (SSRI), the most common type of antidepressant medication, can interfere with interest in sex. Likewise, she added, although systemic hormone therapy with estrogen can reduce vaginal dryness, it can also lower womens natural testosterone, which affec...Antidepressant does not improve symptoms in advanced cancer patients without major depression
...ude: Treatment with a selective serotonin reuptake inhibitor [antidepressant] should be reserved for those with a proven indication....GSK's Pazopanib shows positive results in patients with advanced renal cell carcinoma
...Pazopanib is an oral, investigational angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and c-kit, important proteins in the angiogenic process. Angiogenesis, which is the growth of new blood vessels in the body, plays a criti...GSK's Pazopanib shows positive results in patients with advanced RCC and ovarian cancer
...Pazopanib is an oral, investigational angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and c-kit, important proteins in the angiogenic process. Angiogenesis, which is the growth of new blood vessels in the body, plays a criti...FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
...oval of the only twice-daily leukotriene synthesis inhibitor for asthma, said Mel Engle, President and CEO of DEY. ZYFLO CR has a unique mechanism of action that, combined with its twice-daily dosing regimen, could fundamentally expand and improve the treatment options available to asthma patients. We are d...Ireland Cancer Center researcher lays out benefits of aspirin to prevent colon cancer
...ght provide similar protection as aspirin or COX-2 inhibitor drugs for developing colon cancer but with a lesse...ne, called 15-PGDH, to a naturally occurring Cox-2 inhibitor such as Celebrex. These findings may lead to the development of a new drug for colon cancer preventi...Erectile dysfunction and lower urinary tract symptoms
... comparable to alpha-blocker and 5-alpha-reductase inhibitor therapy for the condition. This study will be presented in Moderated Poster Session 47 on Tuesday, May 22, 2007 starting at 3:30 p.m....Commonly used drug offers promise for premature babies
Scientists have found evidence that the cox-2 inhibitor celecoxib, a common pain reliever used to treat arthritis, may offer a new way to reduce the risk of the most common cause of brain damage in babies born prematurely. The work involves shoring up blood vessels in a part of the brain that in prematu...ACE inhibitors help preserve kidney function in IgA nephropathy
...N were randomly assigned to treatment with the ACE inhibitor benazepril or an inactive placebo. IgA nephropathy... of protein in the urine was also lower in the ACE inhibitor group: three percent versus 26 percent. Overall, the urine protein level remained stable and below...Heart-failure patients benefit from pharmacist care
...iteracy. For example, heart patients taking an ACE inhibitor received their pills in a bottle marked with an ace of hearts sticker. A corresponding information sheet, designed to be easy to read and understand, was also marked with the ace-of-hearts....RAND study finds women with heart disease and diabetes less likely to receive proper care
... less often than men included being prescribed ACE inhibitor drugs for chronic heart failure and receiving prescriptions for beta blocker drugs following a heart attack. Women with diabetes in both Medicare and commercial health plans were more likely to have received eye exams than their male peers. The...Iyengar yoga can promote well-being in women breast cancer survivors
...ast cancer and receiving antiestrogen or aromatase inhibitor hormonal therapy participated in the study. Time since diagnosis was approximately four years. None had any experience with Iyengar yoga. The subjects were randomized to either yoga (n=10) or a wait-list control group (n=9). Beginning level Iyenga...New mechanism identified for resistance to targeted lung cancer drugs
...g resistant cell lines with either Iressa or a MET inhibitor did not stop tumor growth, treatment with both agents did induce cell death. "This method of reactivating the EGFR signalling pathway with MET may be a common resistance mechanism in other therapies that target receptors of the ERBB family, which ...Research could lead to treatment for Alzheimer's disease
...ion of plaques in the brain. The development of an inhibitor compound targeting memapsin 2 could block this rea...llography to map the structure of Ghosh's designed inhibitor bound to the enzyme. This revealed information necessary to move the research forward and develop mo...Drug used to prevent HIV transmission from mother to child damages DNA
...T (zidovudine), a nucleoside reverse transcriptase inhibitor (NRTI), have reduced the rate of transmission from mother to child to less than 2 percent in infants who are not breast fed. NRTIs work by inhibiting the viral reverse transcriptase and by incorporating into the viral DNA and terminating nascent st......ut Sutent,the first multi-targeted tyrosine kinase inhibitor to be approved in the EU for first-line usein mRCC, at the forefront of drug therapy for this devastating condition. Sunitinib malate is an oral therapy belonging to a new class of dual-action multi-targeteddrugs that attack cancer by inhibiting tumo...