Therapeutic unshackles p53 and causes tumor regression
...sinki, Finland, have found that the small-molecule inhibitor Nutlin-3a has antitumor effects in a mouse xenograft model of PEL. In the study, which appears online on March 15 in advance of publication in the April print issue of the Journal of Clinical Investigation, Pivi Ojala and colleagues show that Nutli...News briefs from the journal Chest, March 2007
...ble tissue factor (sTF), and plasminogen activator inhibitor (PAI-1), and D-dimer were gathered and determined. Also, statistical analyses were adjusted for age, gender, ethnicity, body mass index, blood pressure, and smoking history. Results showed that measures of sleep fragmentation and sleep efficiency wer...Early switch to an aromatase inhibitor increases survival
...tients taking tamoxifen, switching to an aromatase inhibitor within three years significantly improves survival...en for two to three years followed by an aromatase inhibitor for the remaining treatment period (413 women). Dr. Boccardo and his colleagues found that compare...New angiogenesis inhibitor has promise for treating deadly brain tumor
...tigation. An oral medication, AZD2171 is a potent inhibitor of the three primary receptors for the powerful angiogenesis factor VEGF, known be present on glioblastoma blood vessels. Manufactured by AstraZeneca, AZD2171 is currently available only to participants in clinical trials. The MGH trial, sponsore...Penn researchers demonstrate ability of new therapy to treat severely elevated cholesterol levels
...ty, tolerability and effects on lipid levels of an inhibitor of MTP in six patients with homozygous FH. Patients received the MTP inhibitor at four different doses, each for four weeks, and returned for a final visit after an additional fou...Study finds unexpected results in acid suppression between two OTC heartburn treatments
...n medications, omeprazole magnesium, a proton pump inhibitor (PPI) and famotidine, a histamine-2 receptor antagonist (H2RAs), in an over-the-counter (OTC) setting. In contrast to general consensus, suggesting first day superiority of H2RAs, the results show similar acid suppression on the first day of dosing b...Most hospital performance measures for heart failure not linked to improved patient outcomes
...olic function, angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) for left ventricular systolic dysfunction (LVSD), adult smoking cessation advice/counseling, and anticoagulant at discharge for patients with atrial fibrillation. Although it is expected that application of these...Study finds limitations in publicly reported quality-of-care indicators for heart-failure patients
...ng patients an angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blockers (ARB) drugs; 4) S...ted with reduced early mortality risk and only ACE inhibitor or ARB use modestly affected mortality or rehospitalization outcomes. Prescribing a beta-blocker in ...Darunavir with FUZEON provides HIV patients a better chance to reach undetectable viral load
... for Human Use (CHMP) of Tibotecs boosted protease inhibitor darunavir is good news for HIV treatment-experienc...arunavir, when used in combination with the fusion inhibitor FUZEON, can substantially increase the chances of reaching undetectable viral load the new treatmen...Mass. General leading international trial of novel breast cancer drug
...t to investigate the use of a dual ErbB1 and ErbB2 inhibitor as an adjuvant treatment for women with HER2-positive breast cancer, who are at a high risk of their disease recurring, says Goss. "The concept of the TEACH study arose from our clinics," says Beverly Moy, MD, a medical oncologist at the MGH Breas...M. D. Anderson reports first drug activity in T315I-Positive CML, ALL and JAK-2-Positive MPD
...er, showed the first clinical activity of a kinase inhibitor against the T315I BCR-ABL mutation found in chronic myeloid leukemia (CML) and acute lymphocytic leukemia (ALL). In addition, the trial showed the first activity against the JAK-2 mutation found in myeloproliferative disorders (MPD), a group of bloo...Five-year study by OHSU Cancer Institute shows Gleevec's excellent survival rate
...eable disease." Gleevec is a signal transduction inhibitor that interferes with the enzymes that trigger the growth of cancerous cells. Gleevec acts on CML cells by inhibiting the disease-causing enzyme BCR-ABL that tells cells to grow and divide. Gleevec has also been approved for people with advanced gas...Drug prescribed for migraines and seizures increases risk of kidney stones
...e urine pH and lowered urine citrate, an important inhibitor of kidney-stone formation. "These changes increase the propensity to form calcium phosphate stones," Dr. Sakhaee said. In the short-term study, urinary calcium and oxalate a chemical compound that binds strongly with calcium and is found in most ca...Cell wall of pneumonia bacteria can cause brain and heart damage
...hway in cardiomyoctyes using a molecule called PLC inhibitor U73122. The treatment prevented the cell from taking up the fragments but did not appear to interfere with the cell's normal functions. This suggests that a drug that blocks the pathway responsible for pulling cell fragments into the cell might not h...Researchers identify new weapon to fight deadly bacterial sepsis
... said. "We're hoping that when an aldose reductase inhibitor is approved as a drug in the U.S. -- one is already in use in Japan for diabetes, by the way -- we can interest clinicians in studying its use against sepsis."...Scientists show drug can counteract muscular dystrophy in mice
.... The scientists tested trichostatin A (TSA), an inhibitor of the enzyme deacetylase, in two mouse models of ...strength of the mice with MD given the deacetylase inhibitor and healthy mice. "This is the first example of using a drug to counteract muscular dystrophy in ...Scientists stop colon cancer growth in mice by blocking just one enzyme
...prolonged use in diabetes, and an aldose reductase inhibitor is already available for clinical use in Japan. Such drugs would likely be used after surgery as a "chemo-preventive" measure to keep cancer cells missed by surgery in check. "As far as I am aware, there is no other chemo-preventive agent that has be...Cancer drug may be remedy for rheumatoid arthritis, Stanford study finds
...th Novartis. "We have taken a very potent kinase inhibitor and discovered that it works very well for an autoimmune disease," said Robinson. "The significance is twofold. First, it might provide insights into the mechanisms underlying rheumatoid arthritis by figuring out what Gleevec inhibits." Second, he ad...Tibotec Therapeutics announces start of largest US study on HIV treatment in women
... failure to prior therapy consisting of a protease inhibitor and/or non-nucleoside reverse transcriptase inhibitor-based highly active antiretroviral treatment regimen of at least 12 weeks. All participants will receive PREZISTA/rtv (600/100mg twice a day) with an optimized background regimen chosen by the in......ic oxide, the co-culture was treated with a select inhibitor of NOS3. Under these conditions, he adds, CO was unable to induce death to the same degree as in control-treated co-cultures. "We concluded that the physical interaction between the two cell types plus the ability to generate NO was crucial for the ...