Studies provide new evidence on risks associated with Cox-2 inhibitors and NSAIDs
...ythmia, indicating no overall evidence for a COX-2 inhibitor class effect." In conclusion, the authors wri...sk." Dr. Graham also mentions that another COX-2 inhibitor NSAID, etoricoxib (which is not approved for use in the United States), recently was reported to hav...New SSRI effective for the treatment of moderate-to-severe premature ejaculation
A selective serotonin reuptake inhibitor (SSRI) developed specifically for the treatment of premature ejaculation is safe and effective for men severely affected by the condition, according to an Article in this week's issue of The Lancet. Premature ejaculation is the most common form of m...Orange juice is better than lemonade at keeping kidney stones away
...vels of citrate, an important acid neutralizer and inhibitor of kidney stone formation. "One reason might be the different constituents of various beverages," Dr. Odvina said. For instance, the citrate in orange and grapefruit juice is accompanied by a potassium ion while the citrate in lemonade and cran...Unlocking colon cancer with key of prevention
... researchers studied celecoxib - a selective COX-2 inhibitor - to prevent the pre-cancerous lesions. "There is no doubt that celecoxib is an effective agent in reducing the size and occurrence of adenomas in patients with higher risks for colorectal cancer," said Levin. In the placebo-controlled, double-b...Study finds that vioxx reduces the risk of colorectal polyps
...trial that shows that the cyclooxygenase-2 (COX-2) inhibitor rofecoxib (VIOXX) reduces the risk of colorectal adenomas, or polyps. Polyps are benign tumors that are precursors to colon cancer, and they are often found in older adults. The results of the study appeared online on August 30 at the American Gast...Rofecoxib significantly reduces the risk of recurrence of colorectal polyps
...30, 2006) The use of the cyclooxygenase-2 (COX-2) inhibitor rofecoxib (Vioxx) reduces the risk of colorectal a... demonstrates such an effect for a selective COX-2 inhibitor in a placebo-controlled randomized study. While previous randomized studies have shown that COX-2 in...HIV drug could be used to prevent cervical cancer, say University of Manchester researchers
...g that is given orally to treat HIV. This protease inhibitor can selectively kill cultured HPV infected cervical cancer cells and, since it is already available as a liquid formulation, it is possible it may work by direct application to the cervix. The research, funded by the Humane Research Trust, is to be...Scientists stop autoimmune disease without shutting off immune system
...inhibits the p38 enzyme. Tests showed that the p38 inhibitor drug didn't prevent autoantibodies from binding to...38 inhibitor. In the two groups that received p38 inhibitor treatment, almost no mice showed clinical signs of pemphigus vulgaris. For instance, in the group t...Updated International AIDS Society guidelines recommend new goal of undetectable viral load
... least two active drugs such as a boosted protease inhibitor (darunavir) and a drug with a new mechanism of action (such as FUZEON) added to a background of an optimised antiretroviral regimen. This strategy is not only recommended by the IAS-US panel guidelines published this week but also by the US Departmen...Panel updates guidelines for treatment of adult HIV infection
... with either a nonnucleoside reverse transcriptase inhibitor (NNRTI) or a protease inhibitor (PI) boosted with low-dose ritonavir. Given the high degree of comparability of the recommended comp...Study shows promise for simplified treatment of HIV infection
...udy indicates that using a single boosted protease inhibitor instead of the standard regimen of 3 drugs for mai... 48 weeks or longer receiving their first protease inhibitor (PI)based regimen. Participants switched PIs to atazanavir-ritonavir at entry and discontinued nucle...Clinical trial evaluates first-line approaches for treating HIV
... efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI), suppressed the virus to undetectable leve...three-drug combination of two NRTIs and a protease inhibitor called lopinavir/ritonavir. Moreover, a third regimen, efavirenz and lopinavir/ritonavir, performed ...Heart failure drugs may be beneficial for patients with hardening of the arteries
...The participants had been randomly assigned an ACE inhibitor or placebo for an average of 4.5 years. They found that ACE inhibitors reduced the risk of a range of outcomes including all-cause mortality (8.9 vs 7.8%), non-fatal heart attack (6.4 vs 5.3%), stroke (2.8 vs 2.2%), and heart failure (2.7 vs 2.1%) wh...New bird flu drug promises to beat the problem of resistance
...l Research Council (MRC) to develop a new class of inhibitor they have discovered into a new kind of antiviral influenza drug. The search for an alternative flu drug has become all the more pressing as the full extent of resistance the ability of the influenza virus to withstand drug treatments - becomes mo...Research leads to first treatment for drug-resistant HIV
...ecessary for HIV to reproduce properly. A protease inhibitor binds to protease, making it unusable by the virus...ing its behavior. Visualizing the structure of the inhibitor as it interacts with the virus shows us how and why it works so well and greatly advances our ongoin...Study identifies potential drug target for Huntington's disease
...isease (MIND) describes their discovery of a novel inhibitor of Poly (ADP-ribose) polymerase (PARP1) and their ...nds on many factors, so it's hard to predict which inhibitor would be most effective against a specific disorder. The more diverse novel inhibitors can be ident...COX-2 inhibitors prescribed to reduce gastrointestinal toxicity prior to the market withdrawals
...n acid-reducing medication or selection of a COX-2 inhibitor NSAID. Then, clinical studies began to uncover ev...n-making. . "The relative GI safety of the COX-2 inhibitor class represented a major therapeutic advance for patients at increased GI risk who require long-ter...W.M. Keck Foundation announces 2006 class of Distinguished Young Scholars in Medical Research
...s those associated with HIV infection and protease inhibitor drug treatment. Russell DeBose-Boyd, Ph.D., Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas - Dr. DeBose-Boyd studies an enzyme, HMG CoA reductase, that controls the production of cholesterol and is th...Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
...ts with varying doses of Y 27632, finding that the inhibitor "causes a dose-dependent fall in the intraluminal ...IAS tone," Dr. Rattan explains. Similarly, the ROK inhibitor caused a fall in the IAS tone in in vitro studies. They also showed that Rho kinase was present in...Women still get lower-quality heart attack care than men, despite hospital improvement efforts
... beta blockers, cholesterol-lowering drugs and ACE inhibitor drugs for patients leaving the hospital. It also seeks to increase the number of patients who get counseling about diet and smoking before they leave the hospital, and sign a contract with their doctor or nurse pledging to follow recommendations and ...