Results of hospital performance measures do not always reflect patient outcomes
...discharge, and angiotensin-converting enzyme (ACE) inhibitor use, and weaker, but statistically significant, correlations between these medication measures and smoking cessation counseling and time to reperfusion therapy measures. Some process measures were significantly correlated with risk-standardized, 30-d...JCI table of contents: July 3, 2006
...ets is therapeutic in hemophilia A with high-titer inhibitor antibodies AUTHOR CONTACT: Robert R. Montgomery Bl...heart function, has recently been identified as an inhibitor of inflammation that acts primarily by activating the A2A adenosine receptor (A2AAR) on lymphoid and...The unknown risks of arthritis
...ich shows encouraging data that treatment with TNF inhibitor reduces the risk of Myocardial Infarction (MI) and Cerebrovascular Accidents (CVA) in rheumatoid arthritis (RA) patients, when compared to patients treated with traditional DMARDs. Recent studies suggest that the excess of deaths in rheumatoid arthr...World's first approval of new HIV drug TMC114 provides potent new treatment option with FUZEON
...oval of TMC114 (darunavir), a new boosted protease inhibitor (PI), provides the opportunity to build a potent new treatment combination with the fusion inhibitor FUZEON (enfuvirtide) that can successfully combat the HIV virus in treatment resistant patients. Dat...Some patients with heart attack shock survive years after aggressive treatment
...ne whether a compound called nitric oxide synthase inhibitor can help shock patients by targeting excess nitric oxide production....Five-year study confirms Gleevec's long-term benefits
... of 4.8 years. Gleevec is a signal transduction inhibitor that interferes with the enzymes that trigger the spread of tumor cells. It acts on GIST by blocking the growth signal of genetic mutations called c-kit and PDGFRA. Subjects with either of these mutations were more likely to respond to Gleevec than t...Longest ever follow-up study of a targeted cancer therapy shows excellent results
... the development of Gleevec, a signal transduction inhibitor that interferes with the enzymes that trigger the spread of cancerous cells. It acts on CML by inhibiting an enzyme produced by the BCR-ABL gene that tells cells to grow and divide. Clinical trials with Gleevec began a new era in cancer treatment...Treating obesity may improve the efficacy of therapy for hepatitis C
...feron alfa (an immune stimulant) and ribavirin (an inhibitor of viral replication). However, this will cure only 55 percent of patients. One of the risk factors for treatment failure is obesity. Obesity itself is linked to the disruption of hormone signaling pathways that affect cell function and to abnormal l...New study re-evaluates cardiovascular risks of anti-inflammatory drugs
... available randomised trials that compared a COX 2 inhibitor with placebo, or a COX 2 inhibitor with a traditional NSAID, and had recorded serious cardiovascular events. By including data from 138...New technology detects risks of drugs to heart sooner
...termath of the withdrawal of Vioxx and other Cox-2 inhibitor drugs over concerns that they may cause heart attacks or stroke, the FDA has proposed guidelines that call upon the pharmaceutical industry to develop better measurement methods for drug safety assessment. In response, pharmaceutical companies are in...Desvenlafaxine data show significant improvement in symptoms of depression in adults vs. placebo
...VS-233), a novel serotonin-norepinephrine reuptake inhibitor (SNRI) at the 2006 American Psychiatric Association Annual Meeting in Toronto. Overall, the phase 3 data results showed desvenlafaxine succinate significantly improved depressive symptoms in adult patients compared to placebo. In a separate study ...Blood pressure drugs associated with reduced risk of esophageal, pancreatic and colon cancers
...lled studies examining the correlation between ACE inhibitor use and esophageal, pancreatic and colon cancer in...ls. Results from the second study showed that ACE inhibitor use offered a 48 percent reduced risk of pancreatic cancer. And in the third study, investigators f...Study investigates Nexium benefits patients with Zollinger-Ellison syndrome
...- A new clinical study shows that the proton pump inhibitor (PPI) NEXIUM (esomeprazole magnesium) maintained normal gastric (stomach) acid levels in patients with Zollinger-Ellison syndrome or idiopathic gastric acid hypersecretion (IGH). Results of the 12-month, multicenter study were presented today at the...Anxiety common in elderly, yet often undiagnosed and undertreated
...at treatment with the selective serotonin reuptake inhibitor (SSRI) citalopram, a drug approved for treating anxiety in younger adults, is equally effective in treating adults over the age of 60. Elderly who took the drug for eight months reported improvement in overall quality of life and mental health. The U...AGA Institute presents cutting-edge research during DDW
....m.) Can aspirin be reintroduced with proton pump inhibitor infusion after endoscopic hemostasis? A double blinded randomized controlled trial. J. Sung et al. (9:10 a.m.) The degree of COX-2 selectivity and risk of cardio and cerebrovascular events. N. Abraham et al. (9:25 a.m.) The Basic Science Plenary...New compound unusually potent at blocking brain cancer growth
...he dual blockade proved to be a safe and effective inhibitor of cancer cell proliferation in mice with the huma...eport in the Cancer Cell paper that one PI3 kinase inhibitor in particular PI-103 -- is unusually effective against gliomas in mice. They believe the inhibitor...JCI table of contents: May 4, 2006
....org/article.php?id=26150 BONE BIOLOGY Peptide inhibitor may prevent bone loss in osteoporosis Two molecules known as RANK and TNFR promote the differentiation of osteoclasts cells that are responsible for the breakdown of bone. This process occurs in healthy individuals as part of the constant renewal ...To avoid stomach upset in arthritis patients, drug combination more effective
...vacid may prove more effective than taking a Cox-2 inhibitor like Celecoxib alone for protecting against stomac...r-the-counter anti-inflammatory by itself, a Cox-2 inhibitor taken alone reduced dyspepsia occurrence by 12 percent. An anti-inflammatory taken with an acid-red...JCI table of contents: May 1, 2006
...ci.org/article.php?id=28535 EDITOR'S PICK Enzyme inhibitor may help lower cholesterol and unclog arteries At...ew features of this pathway that suggest an enzyme inhibitor currently in phase III clinical trials may help reduce cholesterol levels and atherosclerosis in hum...Enzyme inhibitor may help lower cholesterol and unclog arteries
...ew features of this pathway that suggest an enzyme inhibitor currently in phase III clinical trials may help re...rt in humans, this raises the hope of using a CETP inhibitor to elevate HDL levels and therefore reduce the incidence of atherosclerosis....