New drug could reduce tissue damage after heart attack
...as now rationally designed a potent small molecule inhibitor of CRP. The new compound, bis(phosphocholine)-hexa...he CRP inhibitor. "We now propose to develop a CRP inhibitor as rapidly as possible for testing in patients with heart attacks. "The drug would be given as soon ...St. Jude unlocks mystery of very aggressive leukemia
...refore, the St. Jude investigators used a chemical inhibitor of JAK kinases to block the effect of IL-7 on leukemic cells in culture. This treatment restored the ALL cells' sensitivity to imatinib. "Our study of mice with ALL containing both Bcr-Abl and Arf mutations has provided unexpected insights into how f...Researchers reveal lung's unique innate immune system
...a while, but the system's own enzymes activate the inhibitor that puts them back to sleep," said Kenji Takabayshi, Ph.D., first author of the study. Other contributors to this paper include Maripat Corr, Tomoko Hayashi, Vanessa Redecke, Lucinda Beck, and Donald Guiney of the Department of Medicine at UCSD Scho...More than half of older diabetics lack medicines that protect kidneys and heart
...n if a free-medications program only increased ACE inhibitor and ARB use to 50 percent of patients, the Medicar...those clinical indications should be taking an ACE inhibitor or ARB, except for a very small number may not be able to take them. Studies also suggest that the d...ACE inhibitors may reduce death, heart attack and stroke in patients with coronary artery disease
...lar dysfunction or heart failure, suggest that ACE inhibitor therapy should be systematically used in all patients with documented coronary artery disease."...Lack of response to herceptin may be reversed with addition of a PI3K inhibitor
.... We think the combination of Herceptin and a PI3K inhibitor is affecting multiple cancer pathways," she says. "It will be interesting to see if other PI3K inhibiting agents now being developed also will work in HER2-positive, PTEN-negative tumors, as well as in other breast tumors that lack PTEN." Based on pr...Capsaicin shows promise in inhibiting growth of pancreatic cancer
...human pancreatic tumors was an extremely effective inhibitor of the cancer process, inducing apoptosis in cancer cells," said Sanjay K. Srivastava, Ph.D., lead investigator and assistant professor, department of pharmacology, University of Pittsburgh School of Medicine. "Capsaicin triggered the cancerous cells...Depressed monkeys may help scientists understand human depression
...ve no experience with selective serotonin reuptake inhibitor (SSRI) drugs such as Paxil, Prozac and Zoloft, that are often used to treat depression and can alter neurotransmissions, nor have they taken analgesics, alcohol, tobacco or illegal drugs, Shively said. Monkey models can be used to develop new treatme...Bone resorption cells offer drug targets for osteoporosis, rheumatoid arthritis, and more
...ientists have documented that some of the protease inhibitor drugs that have had such a dramatic effect lowerin...osteoclasts, suggesting that changing the protease inhibitor being given might diminish bone loss, or that patients on protease inhibitor drugs may need to take ...JCI Table of Contents, April 3, 2006
...the action of renin by treating the hearts with an inhibitor of renin, which abolished angiotenisn formation. The researchers confirmed these results using hearts obtained from mice. Production of renin by cardiac mast cells represents a novel mechanism for regulating RAS. The authors note that these findings ...COX-2 inhibitors significantly reduce risk of cancer
... find that regular intake of a low dose of a COX-2 inhibitor may be enough to reset the COX-2 cascade and safely protect people against cancer."...Research suggests that immune response protects against brain tumor development
...mation in the brain, and reducing one with a Cox-2 inhibitor may be beneficial," Bondy says. "These are all interesting signals that may give us a clue as to the role of inflammation and development of different kinds of brain tumors," Scheurer says. "We will need much more epidemiological and genetic data to ...New strategies help depressed patients become symptom-free
...ressant citalopram, a selective serotonin reuptake inhibitor (SSRI) for up to 14 weeks had the option of continuing to level 2 of the trial where they could explore additional treatment options designed to help them become symptom-free. "If the first treatment attempt fails, patients should not give up," said...Drug helps cognitive function in brain tumor patients after radiation
... our knowledge, this is the first study of an AChE inhibitor or any other drug administered to long-term surviv... called acetylcholine. They thought use of an AChE inhibitor such as donepezil might increase the acetylcholine level in the brain, decrease cognitive symptoms...Long-term antidepressant therapy best treatment for depression in old age
... that participants who took the serotonin-reuptake inhibitor (SSRI) paroxetine for two years after an initial depressive episode were much less likely to experience a relapse than those who received a placebo. "Prior to this study there was no standard of treatment for the elderly with first episodes of depres...Molecule targets and kills tumor cells, starves blood supply
... anti-angiogenic properties, showing promise as an inhibitor of new blood vessel formation in tumors. ARC, an acronym for its long chemical name, resembles one of the bases that are the building blocks of DNA. Researchers found it by screening more than 2,000 compounds for their ability to inhibit a key step i...Refinements and innovations enhance safety, effectiveness
...rategy (ACUITY) trial compared the direct thrombin inhibitor bivalirudin, with or without a glycoprotein IIb/IIIa inhibitor (GPI, which prevents platelets from clumping together to form a blood clot), to the indirect thrombi...Drug-eluting and absorbable stents push interventional frontiers
... clopidogrel, heparin, and a glycoprotein IIb/IIIa inhibitor (GPI), each of which interferes with a specific st...esigned to compare heparin and the direct thrombin inhibitor bivalirudin in 13,820 patients with moderate-to-high-risk ACS. The results were reported on Sunday,...Seattle Heart Failure Model is able to accurately predict survival for patients with heart failure
...the Seattle Heart Failure Model, if you add an ACE inhibitor the patient will live five years, and if you add an ACE inhibitor and a beta blocker the patient will live six and a half years. "If you use an ACE inhibitor, beta bl......ed with Strep were treated by injecting a chemical inhibitor of the DNA-degrading enzyme at the site of infecti...ounts and tissue injury was observed following the inhibitor treatment, when compared to controls receiving a placebo. Nizet explained that the researchers' find...