UCLA finds cancer drug may improve progeria; genetic disease causes accelerated aging in children
...ng and Stephen Young, tested a farnesyltransferase inhibitor (FTI) in mice with progeria. FTIs were initially developed by pharmaceutical companies to treat cancer. The majority of FTI-treated progeria mice showed improvements in body weight, bone integrity, grip strength, and survival compared with untreate...Prescription painkillers effective in patients with dormant inflammatory bowel disease
...ers, including acetaminophen, naproxen and a COX-2 inhibitor nimesulide for four weeks to determine rate of relapse. This study shows that NSAIDs cause clinical relapse within a few days of ingestion in only 17 to 28 percent of asymptomatic patients with IBD while drugs that were selective for COX-1 and COX-2...JCI table of contents, January 26, 2006
...o Health Sciences Center, now show that loss of an inhibitor of complement, known as complement receptor 1relat...Altered renal tubular expression of the complement inhibitor Crrypermits complement activation after ischemia/reperfusion AUTHOR CONTACT: Joshua M. Thurman Un......ard therapy using an angiotensin-converting enzyme inhibitor (ACE-inhibitor) to intensive therapy using both an ACE-inhibitor and an angiotensin receptor blocker (ARB). Patients will receive a device for measuring blood pressure at home, clinic visits, lab tests, and study medications at no charge. They will...Elderly with alcoholism receive equal heart attack care
...eatment, including the use of beta-blocker and ACE inhibitor drugs, aspirin, angioplasty and advice to quit smoking. With the exception of beta-blockers prescribed upon release from the hospital, patients with an alcohol diagnosis fared no worse than their peers in terms of getting guideline care. Fiellin and ...Initial results help clinicians identify patients with treatment-resistant depression
...irst phase of the study was the serotonin reuptake inhibitor (SSRI) citalopram (Celexa, made by Forest Pharmaceuticals), and response rates were comparable across the 23 psychiatric and 18 primary care treatment sites. John Rush, M.D., and Madhukar Trivedi, M.D., of the University of Texas Southwestern Medica...Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe
...hat significantly reduce the risks of taking COX-2 inhibitor pain relievers, the investigators report. In a pap...ll-known COX-2 pathway that is the target of COX-2 inhibitor drugs such as Vioxx. Until now, these two major inflammatory mechanisms were assumed to be unrelated...Investigational boosted protease inhibitor, TMC114, works better with FUZEON
...fuvirtide) to the investigational boosted protease inhibitor (PI), TMC114/r, more than doubles the proportion of patients reaching undetectable levels of the virus. This latest study provides further evidence that FUZEON now makes undetectable viral loads more achievable for patients failing on their current t...Pular antidepressants boost brain growth, Hopkins scientists report
... team gave either the selective serotonin reuptake inhibitor fluoxetine (Prozac), the selective serotonin reupt...in France) or the selective norepineprine reuptake inhibitor desipramine, a so-called tricyclic antidepressant, to groups of rats for four weeks and studied anat...New studies identify advances in treatment of chronic myeloid leukemia
...MS-354825) is a novel, oral, multi-targeted kinase inhibitor which targets BCR-ABL and SRC protein kinases. The SRC protein is a signaling protein that specializes in messages that control the growth of cells. The drug is 325-fold more potent than imatinib in cells transduced with normal BCR-ABL genes, and ha...Heartfelt wake-up call sounded for heart attack survivors
...which for many include a beta-blocker, statin, ACE inhibitor and aspirin, healthy lifestyle choices and a good support system, they can help prevent a future cardiovascular event and live a full and active life." Survey Reveals Gender Disparities Not only did the survey show that both men and women view the...Low-dose chemotherapy plus antiangiogenesis drug has activity in advanced breast cancer
...g metronomic therapy with a dedicated angiogenesis inhibitor showed clinical activity, and was quite well toler... the chemotherapy was paired with the angiogenesis inhibitor bevacizumab, or Avastin, given intravenously every 14 days. None of the patients had been previously...Scientists unlock solid tumor treatment genetic secrets
...dly, the St. Jude team discovered that a drug-like inhibitor of HDACs called TSA interferes with the ability of HIF to turn on a large number of genes during times of hypoxia. The study further suggests that HDACs appear to cooperate with CBP/p300 to help HIF trigger the expression of most of the approximately...UC Davis researchers shed new light on how chemotherapy-induced leukemia develops
...of the new study. "One is that the topoisomeraseII inhibitor drugs, in combination with the topoisomerase II enzyme theytarget, induce random genetic changes that lead to leukemia onset. Theother is that another, potentially correctable process is at work." In the study, Vaughan and his colleagues at Loyola Un...ANU cancer researcher wins biomedical award
...ssor Parish has developed a synthetic, sugar-based inhibitor of heparanase, called PI-88, which blocks cancer spread and also reduces tumour growth by stopping the growth of new blood vessels in tumours. PI-88 is in commercial development by the Australian biotechnology company, Progen Industries, and is under...Get With The Guidelines program dramatically improves care
...at discharge, as well as use of beta blockers, ACE inhibitor prescriptions for heart attack patients upon discharge, smoking cessation counseling and cholesterol-lowering therapy in appropriate patients. The control group is baseline data (the initial information collected prior to the implementation of an i...Physicians slower to incorporate newer heart drug treatments
...t. Glycoprotein IIb/IIIa inhibitors (a newer clot inhibitor used only in hospital) improved from 33 percent to 47 percent. Dietary modification Improved from 66 percent to 83 percent. Smoking cessation Improved from 59 percent to 85 percent. Cardiac rehabilitation improved from 37 percent to 65 percent. ...Compound from marine bacteria shows potential as multiple myeloma therapy
...n multiple myeloma. NPI-0052 is a novel proteasome inhibitor with a chemical structure and action that is distinct from bortezomib, and has the promise of being even more effective for patients," says Kenneth Anderson, MD, director of the Jerome Lipper Multiple Myeloma Center at Dana-Farber, and senior author...Shire announces positive two-year study of ADDERALL XR in the treatment of adult ADHD
...cently taken a type of antidepressant called a MAO inhibitor or have a pre-existing structural heart abnormality, you should not take Adderall XR. There is a potential for worsening of motion or verbal tics and Tourette's syndrome. A patient should report any new psychological symptoms to his or her physicia......oidal anti-inflammatory agents and the leukotriene inhibitor and anti-asthma drug zileuton. With the promise o..., researchers are developing dual function COX-LOX inhibitor products to offer an alternative to combination therapies. In addition, PPARg ligands (peroxisome p...