New insights into role of tumor necrosis factor on sex hormone production in rheumatoid arthritis
...fortunate to demonstrate that TNF is also a strong inhibitor of the conversion of DHEAS to DHEA in synovial cells from patients with RA but absolutely not in patients with OA." Providing the full picture of androgen deficiency in RA, this study affirms the need for further research into early anti-TNF antibody...Study shows grapefruit extract can heal stomach ulcers
...nduce experimental ulcers) with or without a COX-1 inhibitor (indomethacin, 2 mg/kg) and a COX-2 inhibitor (rofecoxib, 10 mg/kg). Rats treated with GSE at 10 mg/kg experienced a 50 percent reduction in gas...Other highlights in the May 18 JNCI
... addition, the authors identified Triacsin c as an inhibitor of acyl-CoA synthetase, an enzyme that regulates cytochrome c release. Triacsin c induced apoptosome-mediated cell death in tumor cells and suppressed the growth of lung tumors in a mouse model. The authors conclude that acyl-CoA synthetase inhibit...Aspirin use may protect against colon cancer recurrence, reduce risk of death
... of 41 patients (4.7 percent) reported using COX-2 inhibitor anti-inflammatory agents, Celebrex or Vioxx. The researchers found, based on an average follow up of 2.7 years after the second interview, that regular aspirin users had a 55 percent lower risk of colon cancer recurrence and a 48 percent lower risk o...Anti-depressant use linked to increased GI bleeding
...has shown that use of selective serotonin reuptake inhibitor (SSRIs) may be associated with an increased risk of bleeding disorders and hemorrhages. Researchers from Northwestern University examined the use of these and other medications with similar risks in patients admitted to several hospitals with acute ...Failed lung cancer drug could help shrink breast tumors
... 27 women were assigned gefitinib and an aromatase inhibitor called anastrozole (Arimidex) and 29 were assigned gefitinib and placebo for 4-6 weeks prior to receiving surgery. Tumours were reduced in size by 30-99% in 12 of 22 assigned gefitinib and anastrozole and in 14 of 28 patients assigned gefitinib and p...Breast tumor's biological traits guide hormone therapy
...er women should take tamoxifen alone, an aromatase inhibitor alone, or tamoxifen for two years followed by an aromatase inhibitor are issues yet to be clarified by clinical trials. Because there are no data comparing different hor...Lag-time often occurs before new treatments for pediatric HIV infection are used
...he single or dual nucleoside reverse transcriptase inhibitor (NRTI) regimens of the 1980s and early 1990s to to...active antiretroviral therapy including a protease inhibitor became most frequently used. From 1998-2003, 22 percent of children initiated ART with a regimen not...New GP contract may not improve treatment for heart failure patients
...blish patients on an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocking drugs (ARB) fall well short of ensuring the implementation of best practice, partly because they do not include the use of a number of other important treatments such as Beta blockers. Around four fifths...Direct-to-consumer advertising may influence physicians' prescribing decisions
...rchers chose Paxil, a selective serotonin reuptake inhibitor antidepressant, because at the time of the study, it was widely promoted, priced higher than the generic fluoxetine, and available through the participating health care organizations in all three cities. In the control scenario, the patients reported...New treatment for hereditary breast cancer
...hed in Nature, describes how the use of a chemical inhibitor can specifically kill tumour cells, which have a defect in the gene causing hereditary breast cancer. This new treatment targets only the tumour cells and is not likely to affect other healthy cells in the body. The discovery could also lead to a pro...Two drugs combined more cost-effective safer for managing arthritis in high-risk patients
...ibitor) such as Prevacid or Nexium; and 3) a Cox-2 inhibitor (cyclooxygenase 2-selective inhibitor) alone, such...s an acid-lowering drug, compared to using a Cox-2 inhibitor drug alone, which guidelines had traditionally recommended as a first-line therapy for this patient ...Diuretics best initial therapy for both black and nonblack patients in treating high blood pressure
...onducted this analysis to determine whether an ACE inhibitor or CCB is superior to a thiazide-type diuretic in .... Participants took either a CCB (amlodipine), ACE inhibitor (lisinopril), or a thiazide-type diuretic (chlorthalidone). Other medications were added to achieve ...