Tag: "inhibitors" at medical news
Pathway links inflammation, angiogenesis and breast cancer
...ns by suppressing mTOR. Rapamycin and similar mTOR inhibitors
are in early clinical trials for a number of cancers at M. D. Anderson and elsewhere. One drug, temsirolimus, has been approved to treat renal cell carcinoma. Hung's lab is exploring the possibility that this TNFa-driven activation of mTOR is the m...
UIC researchers to develop new drugs to fight bioterrorism
...hogen in host tissues; rational development of new inhibitors
of a key enzyme in fatty acid biosynthesis (Fab1) in many gram-positive and gram-negative bacteria; and the development and screening of natural products for their therapeutic potential against anthrax and other infectious agents such as Y. pestis, F...
From UF and IBM, a blueprint for 'smart' health care
...Doing so in an open environment will remove market inhibitors
that impede innovation in critical industries like health care and open a broader device market thats fueled by uninterrupted networking. Helal has devoted the past several years to developing smart devices for the elderly in a model home known as ...
Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
...ue University, have demonstrated that HIV protease inhibitors
crucial drugs for HIV treatment block a cellular...ine at UCLA. UCLA researchers added HIV protease inhibitors
to cultures of mouse and human fibroblast cells. They found that the inhibition of ZMPSTE24 by the H...
Future therapies for stroke may block cell death
...direction to follow in testing histone deacetylase inhibitors
in animal models for diseases such as Parkinson's ...earch has gone into developing histone deacetylase inhibitors
as novel therapeutics, but the majority of the work has been directed toward cancer, Kozikowski said...
Extra pay does not improve hospital performance
...and the use of angiotensin-converting enzyme (ACE) inhibitors
or angiotensin receptor blockers for weakened left pumping chambers. These measures were selected because clinical trials have proven that their use improves the outcomes for heart attack patients. The monetary incentive for the CMS study was relat...
Gene variations point to why lung cancer drugs work better in Japanese vs. US patients
...nese and U.S. patients respond differently to EGFR inhibitors
such as erlotinib, a relatively new targeted therapy that is another important class of drugs for lung cancer....
Shark cartilage shows no benefit as a therapeutic agent for lung cancer
...e supported the hypothesis that cartilage contains inhibitors
of angiogenesis. Also, shark cartilage has long intrigued the public due to the belief that the incidence of cancer in this cartilaginous fish is very rare. Early Phase I and II studies in lung and renal cancers suggested some benefit to patients whe...
FDA approves ZYFLO CR extended-release tablets for chronic treatment of asthma
...s) are the only FDA-approved leukotriene synthesis inhibitors
for the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older. ZYFLO CR and ZYFLO are not indicated for use in the reversal of bronchospasm in acute asthma attacks, but can be continued during acute exacerbatio...
Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage
...like non-steroidal, anti-inflammatory drugs, COX-2 inhibitors
and acetominophen. Morphine and its derivatives are still in common use as well, but can depress breathing and lead to addiction. Taken together, current treatments deliver inconsistent results and new approaches are needed, researcher said. Gene the...
COX inhibitors may weaken protective qualities of estrogen hormone therapy
... a database study of women heart patients that COX inhibitors
such as traditional nonsteroidal anti-inflammatory...ributable to a pharmacological interaction between inhibitors
of COX-2 and estrogen, the researchers examined the medical records of 1,673 women between 50 and 84...
Ireland Cancer Center researcher lays out benefits of aspirin to prevent colon cancer
...ts who were given aspirin or COX-2 selective NSAID inhibitors
and observational trials have associated a decreased risk of colon cancer with aspirin use," writes Dr. Markowitz in the editorial. "The researchers' findings provide powerful support for the role of COX-2 as a key mediator in the development of colo...
Erectile dysfunction and lower urinary tract symptoms
...(BPH) may be improved with phosphodiesterase (PDE) inhibitors
drugs commonly prescribed for certain types of ED...ogical Association (AUA) focus on the use of PDE-5 inhibitors
in treating men with co-existent LUTS and ED. A special session for media moderated by Kevin T. McVa...
Quality improvement effort pays off in diabetes care
...m 25 percent to 44 percent. Prescriptions for ACE inhibitors
rose from 33 percent of patients to 55 percent, and aspirin prescriptions rose from 22 percent to 45 percent. These improvements added very little expense. The diabetes quality-improvement program cost about $700 per patient the first year, $600 t...
JCI table of contents -- May 17, 2007
...xtrapolated to human sickle disease, predicts that inhibitors
of K-Cl cotransport, if used alone, would not be maximally effective in reversing the red cell dehydration that causes sickling. TITLE: Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydrat...
ACE inhibitors help preserve kidney function in IgA nephropathy
...treatment with angiotensin-converting enzyme (ACE) inhibitors
can reduce the long-term risk of irreversible kidn...lacebo group. Recent studies have shown that ACE inhibitors
are helpful for patients with various kidney diseases. Some studies have found ACE inhibitors
Anxiety hikes risk of heart attack, death
...sidering the role of angiotensin-converting enzyme inhibitors
or beta blockers, have not routinely included sleep studies; therefore, the impact of sleep apnea on survival was not known," the authors noted....
Effectiveness of first renin inhibitor drug for treating hypertension is limited
...sting classes are beta blockers, converting enzyme inhibitors
(CEIs) and angiotensin receptor blockers (ARBs). Many drugs in these classes have lost patent protection and are available as generics. In analyzing clinical trials involving over 5000 hypertensive patients, aliskiren was not more effective as an a...
UK researchers find new class of nontoxic cancer treatments
...s currently treated with broadly acting proteasome inhibitors
and chemotherapeutics.Kim and Mohan also suggest that UK-101 may be useful in treating a number of diseases in which LMP2 is involved. The researchers are particularly excited about UK-101s potential in treating inflammatory conditions associated wi...
Other highlights in the May 2 JNCI
..., and tamoxifen. A combination of all three HER inhibitors
was more effective at slowing tumor growth than a ... the treatment. In mice treated with all three HER inhibitors
plus tamoxifen or estrogen withdrawal, most tumors completely disappeared and did not progress for m...
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