Tag: "interferon" at medical news

Damon Runyon renews its $2.25 million investment to support young clinical cancer investigators

...mber of cancers. Little is known about how or why interferon kills cancer cells. Under the mentorship of Dr. W.... Ramos works to clarify the precise mechanisms of interferon therapy in ATLL and identify the specific molecular markers associated with response and prognosis. ...

GSK's Pazopanib shows positive results in patients with advanced renal cell carcinoma

...t human interleukin-2 (IL-2) and recombinant human interferon -2b (IFN-), either alone or in combination, have been widely used in patients with advanced disease. Although high-dose IL-2 has shown promise with durable complete remissions observed in 7% of patients, toxicity has limited its widespread use. Lo...

GSK's Pazopanib shows positive results in patients with advanced RCC and ovarian cancer

...t human interleukin-2 (IL-2) and recombinant human interferon -2b (IFN-), either alone or in combination, have been widely used in patients with advanced disease. Although high-dose IL-2 has shown promise with durable complete remissions observed in 7% of patients, toxicity has limited its widespread use. Lo...

Protein may be linked to melanoma recurrence

...ients who initially respond well to treatment with interferon are at high risk of their cancer recurring, said J...ctors of who will benefit most from treatment with interferon and who is most at risk of their cancer returning. The study also found that patients who survive...

When HIV and liver disease co-exist

...fected patients, studies have shown that pegylated interferon with ribavirin is better than interferon-only regimens. For patients with HIV/HBV, combination therapy is routine, though viral mutation and drug resistance remain troubling issues. A key topic of conversation was the development of new agents for tr...

Doctors conclude temsirolimus is effective new treatment for advanced renal cell carcinoma

...atients who received both drugs - temsirolimus and interferon - did not appear to live longer than those given i...s (49 percent) compared with patients treated with interferon only. Patients treated with temsirolimus and interferon combined had a 15 percent increase in median...

Hepatitis B patients' understanding of infection and treatment deficient

...on antiviral therapy. Of those, 24 percent were on interferon treatment. Most of these patients were males between the ages of 31 and 50, with about half being of Asian descent. In addition, 64 percent were from the mid-Atlantic or Pacific regions of the United States. The study was based on Internet interviews...

Cure for hepatitis C announced by VCU researcher

... among about 40 sites worldwide studying pegylated interferon alfa-2a, manufactured by Roche Inc. Nearly all -- 99 percent of patients with hepatitis C who were treated successfully with peginterferon alone, or in combination with ribavirin, had no detectable virus up to seven years later. Researchers say th...

Could statins be a new option for hepatitis C patients?

...or hepatitis C since the introduction of pegylated interferon in 2001, the opportunity to develop a new generation of therapies that offer better outcomes may be imminent. DDW is the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastr...

Stanford researchers identify immune dysfunction in melanoma patients

...ilure. Finding the disruption in the cancer cells' interferon response could help in the development of vaccines... immune cells of normal people. To verify that the interferon signaling was defective in people with melanoma, Critchley-Thorne isolated those cells and exposed t...

Jefferson immunology researchers show blood-brain barrier damage could affect MS severity

...flammatory cells such as NF kappaB, TNF-alpha, and interferon alpha, beta and gamma that contribute to disease. The researchers established EAE in each mouse strain and examined what was common to all of the animals when they developed disease. "Whats astounding is that mice that wouldnt be expected to devel...

Natural, soy-based substance might help fight MS, Jefferson neuroscientists find

...t therapies for MS involve injecting drugs such as interferon and copaxane, one goal is to develop an oral agent. BBIC could be given by pill daily. Over 400,000 Americans acknowledge having MS, though nearly one million Americans may be living with the disease. Symptoms can include fatigue, loss of coordin...

5-year study shows Gleevec's potency against chronic myeloid leukemia

... given Gleevec or the previous standard treatment, interferon alfa plus cytarabine. However, the superiority of Gleevec led the researchers to change the study into a long-term assessment of Gleevec's efficacy. The major finding of the study was that only five percent of the patients died from CML during the fi...

Baylor Research Institute receives $6.2 million grant to establish Center for Lupus Research

...s to continue to characterize the role that type I interferon plays in lupus disease progression," explains Dr. Banchereau. We are currently in collaboration with a biotech company to develop a blocker for type I interferon. The goal is to control the symptom flares that are common to lupus patients by shuttin...

Making headway against hepatitis C: SLU study shows new drug combo effective in nonresponders

...going study. Infergen is a highly potent type of interferon currently used for adult patients with chronic hepatitis C three times a week, Bacon says. This trial is expected to be completed in 2007. An estimated 3.9 million Americans have hepatitis C. About 250,000 who have been offered therapy are unrespon...

Study unveils how West Nile virus evades immune defenses, points to vaccine development

...ignaling activity of a protein receptor called the interferon alpha/beta receptor, or IFNAR, disrupting a cell's...e and spread. This highlights the integral role of interferon and IFNAR signaling in innate immunity. Dr. Gale said the mechanisms at work in the African strain c...

New blood tests aid detection of latent tuberculosis

...he T-SPOT.TB and QuantiFERON-TB Gold, tests detect interferon gamma released in T cells in response to M. tuberculosis- specific antigens. (T cells, a type of white blood cell, produce a number of substances that regulate the body's immune response.) The U.S. Food and Drug Administration (FDA) recently approv...

Hopkins study reveals white blood cells can both hurt and help transplanted kidneys

...micals tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma), which are known to produce cellular damage in kidneys. These chemicals are produced by T cells. The mice that underwent fake surgery also had an elevated level of T cells when compared to the normal mice, but these cells did not ...

African Americans have lower response rate to standard therapy for hepatitis C

...arly as the fourth week of treatment. A pegylated interferon combined with ribavirin is standard therapy for HC...ing supplementary studies in genetics, immunology, interferon signaling and pharmacology, and virology. However, our study results indicate that the reduced respo...

T cells activated to fight HIV basis for dendritic cell therapeutic vaccine

... substance that binds to certain immune cells, and interferon gamma were added to dendritic cells. In the study, white blood cells called monocytes were obtained from both HIV patients and individuals not infected with the virus. In the laboratory, the researchers coaxed them to differentiate into mature de...

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(Date:10/18/2014)... for evaluation of suspected genetic conditions, whole-exome sequencing ... including detection of a number of rare genetic ... to a study appearing in JAMA . ... the American Society of Human Genetics annual meeting. ... regions of thousands of genes simultaneously using next-generation ...
(Date:10/17/2014)... Researchers from the University of Copenhagen have shown for ... the lungs of Cystic fibrosis patients, giving them the ... growth in chronic infections. , The study also discovered ... fibrosis (CF) patients was halted or slowed down by ... consumed all the oxygen and helped "suffocate" the bacteria, ...
(Date:10/16/2014)... a new synthesis of recent research findings to inform ... the two states. , The Ecology and Management ... A Synthesis of the Relevant Biophysical Science and Implications ... by the U.S. Forest Service,s Pacific Northwest Research Station, ... for a synthesis of the large body of scientific ...
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